公开(公告)号：US06847847B2

公开(公告)日：2005-01-25

申请号：US10011641

申请日：2001-11-07

申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

IPC分类号： A61F2/14 ,  A61F9/08 ,  A61N1/36

CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/3787

摘要： A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

摘要翻译： 一种视网膜植入物，包括适于植入眼睛内部的芯片，视网膜视网膜与视网膜接触。 该芯片在面向透镜的一侧具有多个像素元件，用于接收投影到视网膜中的图像，以及多个用于刺激视网膜细胞的电极。 植入物还包括用于感应地耦合到其中的电磁能的接收器线圈。 接收器线圈耦合到用于将感应到接收器线圈的交流电压以适于供应芯片的直流电压的装置。 接收器线圈被配置为与芯片分离的部件，并且用于定位在巩膜外的眼球上。 芯片通过连接引线连接到接收器线圈，该连接引线在植入条件下将眼球的内部和外部互连。

公开(公告)号：US06804560B2

公开(公告)日：2004-10-12

申请号：US10011451

申请日：2001-11-07

申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hammerle ,  Eberhart Zrenner ,  Martin Stelzle

发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hammerle ,  Eberhart Zrenner ,  Martin Stelzle

IPC分类号： A61N118

CPC分类号： A61F2/14 ,  A61N1/0543 ,  A61N1/36046 ,  H01L27/14609

摘要： A retina implant, comprises a surface and a plurality of pixel elements disposed on the surface for receiving and converting incoming light energy into electric energy. At least one amplifier is provided in the implant, and a plurality of stimulation electrodes supplied via the at least one amplifier as a function of signals received by the pixel elements. At least one light-sensitive reference element is coupled with the at least one amplifier for controlling amplification thereof as a function of light energy impinging on the at least one reference element.

摘要翻译： 视网膜植入物包括设置在表面上的表面和多个像素元件，用于接收和将入射的光能转换成电能。 在植入物中提供至少一个放大器，以及经由至少一个放大器提供的多个刺激电极作为由像素元件接收的信号的函数。 至少一个光敏参考元件与至少一个放大器耦合，用于控制其作为照射在至少一个参考元件上的光能的函数的放大。

公开(公告)号：US06298270B1

公开(公告)日：2001-10-02

申请号：US09298684

申请日：1999-04-23

申请人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

发明人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

IPC分类号： A61N118

CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/36046

摘要： A retina implant has a substrate with a surface for applying same to a retina. The substrate comprises electrodes for stimulating cells within the retina. The electrodes are provided on the surface and are exposed to visible light impinging on the retina such that stimuli are exerted on the cells by the electrodes. The implant, further, comprises a photovoltaic layer responsive to non-visible light. The stimuli are locally switched utilizing a voltage generated by the photovoltaic layer.

摘要翻译： 视网膜植入物具有用于将其施加到视网膜的表面的基底。 底物包括用于刺激视网膜内的细胞的电极。 电极设置在表面上并且暴露于入射到视网膜上的可见光，使得通过电极对细胞施加刺激。 此外，植入物包括响应于不可见光的光伏层。 利用由光伏层产生的电压来本地切换刺激。

公开(公告)号：US06347250B1

公开(公告)日：2002-02-12

申请号：US09298816

申请日：1999-04-23

申请人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Elke Günther ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

发明人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Elke Günther ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

IPC分类号： A61N136

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/05 ,  A61N1/326

摘要： An optically controllable microelectrode array for stimulating cells within a tissue is disclosed. The array comprises a substrate having a surface. The substrate is adapted to be placed on the tissue with the surface adjoining the cells. The substrate further comprises a plurality of electrodes on the surface in contact with the cells for stimulating the cells. The electrodes are dimensioned such that a first surface area on the electrodes in contact with the cells is essentially smaller than a second surface area on the cells in which the cells may be contacted by the electrodes. An electrical stimulus is exerted from the electrodes to the cells under the control of light impinging on the tissue.

摘要翻译： 公开了一种用于刺激组织内的细胞的光学可控微电极阵列。 阵列包括具有表面的基底。 衬底适于放置在组织上，表面与细胞相邻。 衬底还包括与用于刺激细胞的细胞接触的表面上的多个电极。 电极的尺寸被设计成使得与电池接触的电极上的第一表面区域基本上小于细胞可以被电极接触的细胞上的第二表面区域。 在光照射在组织上的光的控制下，从电极向细胞施加电刺激。

公开(公告)号：US07126632B2

公开(公告)日：2006-10-24

申请号：US10192304

申请日：2002-07-10

申请人： Bernd Hofflinger ,  Heinz Gerhard Graf

发明人： Bernd Hofflinger ,  Heinz Gerhard Graf

IPC分类号： H04N5/202 ,  H04N9/68

CPC分类号： H04N1/60

摘要： A method for the transformation of image signals that have been obtained by color filtering and have been logarithmically compressed is proposed. The color saturation of the recorded images is increased thereby. According to one aspect of the invention, the transformed image signals are determined as a function of the logarithmically compressed image signals and the logarithmically compressed brightness signals for a spectral color.