公开(公告)号：US07751896B2

公开(公告)日：2010-07-06

申请号：US11305920

申请日：2005-12-19

申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

IPC分类号： A61F2/14

CPC分类号： A61N1/36046

摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

公开(公告)号：US20080081947A1

公开(公告)日：2008-04-03

申请号：US11867324

申请日：2007-10-04

申请人： Klaus Irion ,  Fritz Hensler ,  Christine Harendt ,  Heinz-Gerhard Graf ,  Robert Puers ,  David Turgis ,  Bert Lenaerts ,  Alberto Arena ,  Arianna Menciassi ,  Vassilis Kodogiannis

发明人： Klaus Irion ,  Fritz Hensler ,  Christine Harendt ,  Heinz-Gerhard Graf ,  Robert Puers ,  David Turgis ,  Bert Lenaerts ,  Alberto Arena ,  Arianna Menciassi ,  Vassilis Kodogiannis

IPC分类号： A61B1/04

CPC分类号： A61B1/041 ,  A61B1/00016 ,  A61B1/00029 ,  A61B1/00032 ,  A61B1/00183 ,  A61B2560/0219

摘要： The invention relates to an intracorporeal probe (10), for example preferably for examining hollow organs or natural or artificially created body cavities in the human or animal body, the probe (10) being designed in the form of a capsule that can be introduced into the body without external connecting elements, comprising an elongate housing (16) and an image pickup unit (26) inside the housing (16) that is designed for optically recording a region (pickup region) outside the probe (10). The image pickup unit (26) is held in a fashion capable of moving inside the housing (16) in order to vary the pickup region by means of such a movement (FIG. 1).

摘要翻译： 本发明涉及一种体内探针（10），例如优选地用于检查人或动物体中的中空器官或天然或人造创造的体腔，所述探针（10）被设计成胶囊的形式，其可以被引入 所述主体没有外部连接元件，包括在所述壳体（16）内的细长壳体（16）和图像拾取单元（26），所述图像拾取单元设计成用于光学地记录所述探针（10）外部的区域（拾取区域）。 图像拾取单元（26）以能够在壳体（16）内移动以便通过这种移动（图1）改变拾取区域的方式被保持。

公开(公告)号：US06347250B1

公开(公告)日：2002-02-12

申请号：US09298816

申请日：1999-04-23

申请人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Elke Günther ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

发明人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Elke Günther ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

IPC分类号： A61N136

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/05 ,  A61N1/326

摘要： An optically controllable microelectrode array for stimulating cells within a tissue is disclosed. The array comprises a substrate having a surface. The substrate is adapted to be placed on the tissue with the surface adjoining the cells. The substrate further comprises a plurality of electrodes on the surface in contact with the cells for stimulating the cells. The electrodes are dimensioned such that a first surface area on the electrodes in contact with the cells is essentially smaller than a second surface area on the cells in which the cells may be contacted by the electrodes. An electrical stimulus is exerted from the electrodes to the cells under the control of light impinging on the tissue.

摘要翻译： 公开了一种用于刺激组织内的细胞的光学可控微电极阵列。 阵列包括具有表面的基底。 衬底适于放置在组织上，表面与细胞相邻。 衬底还包括与用于刺激细胞的细胞接触的表面上的多个电极。 电极的尺寸被设计成使得与电池接触的电极上的第一表面区域基本上小于细胞可以被电极接触的细胞上的第二表面区域。 在光照射在组织上的光的控制下，从电极向细胞施加电刺激。

公开(公告)号：US09028399B2

公开(公告)日：2015-05-12

申请号：US11867324

申请日：2007-10-04

申请人： Klaus M. Irion ,  Fritz Hensler ,  Christine Harendt ,  Heinz-Gerhard Graf ,  Robert Puers ,  David Turgis ,  Bert Lenaerts ,  Alberto Arena ,  Arianna Menciassi ,  Vassilis Kodogiannis

发明人： Klaus M. Irion ,  Fritz Hensler ,  Christine Harendt ,  Heinz-Gerhard Graf ,  Robert Puers ,  David Turgis ,  Bert Lenaerts ,  Alberto Arena ,  Arianna Menciassi ,  Vassilis Kodogiannis

IPC分类号： A61B1/06 ,  A61B1/04 ,  A61B1/00

CPC分类号： A61B1/041 ,  A61B1/00016 ,  A61B1/00029 ,  A61B1/00032 ,  A61B1/00183 ,  A61B2560/0219

摘要： The invention relates to an intracorporeal probe (10), for example preferably for examining hollow organs or natural or artificially created body cavities in the human or animal body, the probe (10) being designed in the form of a capsule that can be introduced into the body without external connecting elements, comprising an elongate housing (16) and an image pickup unit (26) inside the housing (16) that is designed for optically recording a region (pickup region) outside the probe (10). The image pickup unit (26) is held in a fashion capable of moving inside the housing (16) in order to vary the pickup region by means of such a movement (FIG. 1).

摘要翻译： 本发明涉及一种体内探针（10），例如优选地用于检查人或动物体中的中空器官或天然或人造创造的体腔，所述探针（10）被设计成胶囊的形式，其可以被引入 所述主体没有外部连接元件，包括在所述壳体（16）内的细长壳体（16）和图像拾取单元（26），所述图像拾取单元设计成用于光学地记录所述探针（10）外部的区域（拾取区域）。 图像拾取单元（26）以能够在壳体（16）内移动以便通过这种移动（图1）改变拾取区域的方式被保持。

公开(公告)号：US20100278212A1

公开(公告)日：2010-11-04

申请号：US12773349

申请日：2010-05-04

申请人： Joachim N. BURGHARTZ ,  Franz Xaver Hutter ,  Daniel Brosch ,  Heinz-Gerhard Graf

发明人： Joachim N. BURGHARTZ ,  Franz Xaver Hutter ,  Daniel Brosch ,  Heinz-Gerhard Graf

IPC分类号： H01L25/00 ,  G01J5/00

CPC分类号： G01J5/60 ,  G01J5/602 ,  H01L31/02005 ,  H01L31/02165 ,  H01L31/103 ,  H01L31/105

摘要： A circuit arrangement for generating light-dependent and temperature-dependent signals has a number of first and second sensor elements, which generate a number of first and second electrical signals. The first and second electrical signals depend on electromagnetic radiation impinging on the circuit arrangement. The first sensor elements are designed to generate the first electrical signals in a manner dependent on electromagnetic radiation from a first wavelength range which comprises a substantial part of the visible light. The second sensor elements are designed to generate the second electrical signals in a manner dependent on electromagnetic radiation from a second wavelength range which predominantly comprises infrared radiation. The first wavelength range overlaps the second wavelength range and it therefore also comprises infrared radiation.

摘要翻译： 用于产生光依赖和依赖于温度的信号的电路装置具有多个第一和第二传感器元件，其产生多个第一和第二电信号。 第一和第二电信号取决于照射在电路装置上的电磁辐射。 第一传感器元件被设计成以取决于包括大部分可见光的第一波长范围的电磁辐射的方式产生第一电信号。 第二传感器元件被设计成以取决于主要包括红外辐射的第二波长范围的电磁辐射的方式产生第二电信号。 第一波长范围与第二波长范围重叠，因此也包括红外辐射。

公开(公告)号：US20060069416A1

公开(公告)日：2006-03-30

申请号：US11194017

申请日：2005-07-29

申请人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

发明人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

IPC分类号： A61N1/18

CPC分类号： A61N1/36046

摘要： The present invention relates to a retina implant for the functional electrostimulation of a retina as a function of incident light. The retina implant has a stimulation chip that is designed to be implanted in the area of the retina of an eye. It further includes a radiation receiver that provides energy for the stimulation chip as a function of invisible radiation that occurs. In accordance with one aspect of the present invention, the radiation receiver is designed so as to be implanted in the area of the eye in a fashion spatially separated from the stimulation chip. The stimulation chip also has decoupling means in order to separate invisible scattered radiation from impinging visible light.

摘要翻译： 本发明涉及视网膜植入物，用于根据入射光的功能性电刺激视网膜。 视网膜植入物具有被设计成植入眼睛视网膜区域的刺激芯片。 它还包括辐射接收器，其作为发生的不可见辐射的函数为刺激芯片提供能量。 根据本发明的一个方面，辐射接收器设计成以与刺激芯片空间分离的方式植入眼睛区域。 刺激芯片还具有去耦装置，以便将不可见的散射辐射与入射的可见光分开。

公开(公告)号：US08309924B2

公开(公告)日：2012-11-13

申请号：US12773349

申请日：2010-05-04

申请人： Joachim N. Burghartz ,  Franz Xaver Hutter ,  Daniel Brosch ,  Heinz-Gerhard Graf

发明人： Joachim N. Burghartz ,  Franz Xaver Hutter ,  Daniel Brosch ,  Heinz-Gerhard Graf

IPC分类号： H01L25/00

CPC分类号： G01J5/60 ,  G01J5/602 ,  H01L31/02005 ,  H01L31/02165 ,  H01L31/103 ,  H01L31/105

摘要： A circuit arrangement for generating light-dependent and temperature-dependent signals has a number of first and second sensor elements, which generate a number of first and second electrical signals. The first and second electrical signals depend on electromagnetic radiation impinging on the circuit arrangement. The first sensor elements are designed to generate the first electrical signals in a manner dependent on electromagnetic radiation from a first wavelength range which comprises a substantial part of the visible light. The second sensor elements are designed to generate the second electrical signals in a manner dependent on electromagnetic radiation from a second wavelength range which predominantly comprises infrared radiation. The first wavelength range overlaps the second wavelength range and it therefore also comprises infrared radiation.

摘要翻译： 用于产生光依赖和依赖于温度的信号的电路装置具有多个第一和第二传感器元件，其产生多个第一和第二电信号。 第一和第二电信号取决于照射在电路装置上的电磁辐射。 第一传感器元件被设计成以取决于包括大部分可见光的第一波长范围的电磁辐射的方式产生第一电信号。 第二传感器元件被设计成以取决于主要包括红外辐射的第二波长范围的电磁辐射的方式产生第二电信号。 第一波长范围与第二波长范围重叠，因此也包括红外辐射。

公开(公告)号：US20060184245A1

公开(公告)日：2006-08-17

申请号：US11305920

申请日：2005-12-19

申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

IPC分类号： A61F2/14

CPC分类号： A61N1/36046

摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

公开(公告)号：US06847847B2

公开(公告)日：2005-01-25

申请号：US10011641

申请日：2001-11-07

申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

IPC分类号： A61F2/14 ,  A61F9/08 ,  A61N1/36

CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/3787

摘要： A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

摘要翻译： 一种视网膜植入物，包括适于植入眼睛内部的芯片，视网膜视网膜与视网膜接触。 该芯片在面向透镜的一侧具有多个像素元件，用于接收投影到视网膜中的图像，以及多个用于刺激视网膜细胞的电极。 植入物还包括用于感应地耦合到其中的电磁能的接收器线圈。 接收器线圈耦合到用于将感应到接收器线圈的交流电压以适于供应芯片的直流电压的装置。 接收器线圈被配置为与芯片分离的部件，并且用于定位在巩膜外的眼球上。 芯片通过连接引线连接到接收器线圈，该连接引线在植入条件下将眼球的内部和外部互连。

公开(公告)号：US06804560B2

公开(公告)日：2004-10-12

申请号：US10011451

申请日：2001-11-07

申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hammerle ,  Eberhart Zrenner ,  Martin Stelzle

发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hammerle ,  Eberhart Zrenner ,  Martin Stelzle

IPC分类号： A61N118

CPC分类号： A61F2/14 ,  A61N1/0543 ,  A61N1/36046 ,  H01L27/14609

摘要： A retina implant, comprises a surface and a plurality of pixel elements disposed on the surface for receiving and converting incoming light energy into electric energy. At least one amplifier is provided in the implant, and a plurality of stimulation electrodes supplied via the at least one amplifier as a function of signals received by the pixel elements. At least one light-sensitive reference element is coupled with the at least one amplifier for controlling amplification thereof as a function of light energy impinging on the at least one reference element.

摘要翻译： 视网膜植入物包括设置在表面上的表面和多个像素元件，用于接收和将入射的光能转换成电能。 在植入物中提供至少一个放大器，以及经由至少一个放大器提供的多个刺激电极作为由像素元件接收的信号的函数。 至少一个光敏参考元件与至少一个放大器耦合，用于控制其作为照射在至少一个参考元件上的光能的函数的放大。