公开(公告)号：US06347250B1

公开(公告)日：2002-02-12

申请号：US09298816

申请日：1999-04-23

申请人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Elke Günther ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

发明人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Elke Günther ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

IPC分类号： A61N136

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/05 ,  A61N1/326

摘要： An optically controllable microelectrode array for stimulating cells within a tissue is disclosed. The array comprises a substrate having a surface. The substrate is adapted to be placed on the tissue with the surface adjoining the cells. The substrate further comprises a plurality of electrodes on the surface in contact with the cells for stimulating the cells. The electrodes are dimensioned such that a first surface area on the electrodes in contact with the cells is essentially smaller than a second surface area on the cells in which the cells may be contacted by the electrodes. An electrical stimulus is exerted from the electrodes to the cells under the control of light impinging on the tissue.

摘要翻译： 公开了一种用于刺激组织内的细胞的光学可控微电极阵列。 阵列包括具有表面的基底。 衬底适于放置在组织上，表面与细胞相邻。 衬底还包括与用于刺激细胞的细胞接触的表面上的多个电极。 电极的尺寸被设计成使得与电池接触的电极上的第一表面区域基本上小于细胞可以被电极接触的细胞上的第二表面区域。 在光照射在组织上的光的控制下，从电极向细胞施加电刺激。

公开(公告)号：US06298270B1

公开(公告)日：2001-10-02

申请号：US09298684

申请日：1999-04-23

申请人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

发明人： Wilfried Nisch ,  Martin Stelzle ,  Stefan Weiss ,  Eberhart Zrenner ,  Alfred Stett ,  Heinz Gerhard Graf ,  Michael Graf ,  Markus B. Schubert ,  Harald N. Wanka ,  Anke Hierzenberger

IPC分类号： A61N118

CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/36046

摘要： A retina implant has a substrate with a surface for applying same to a retina. The substrate comprises electrodes for stimulating cells within the retina. The electrodes are provided on the surface and are exposed to visible light impinging on the retina such that stimuli are exerted on the cells by the electrodes. The implant, further, comprises a photovoltaic layer responsive to non-visible light. The stimuli are locally switched utilizing a voltage generated by the photovoltaic layer.

摘要翻译： 视网膜植入物具有用于将其施加到视网膜的表面的基底。 底物包括用于刺激视网膜内的细胞的电极。 电极设置在表面上并且暴露于入射到视网膜上的可见光，使得通过电极对细胞施加刺激。 此外，植入物包括响应于不可见光的光伏层。 利用由光伏层产生的电压来本地切换刺激。

公开(公告)号：US06804560B2

公开(公告)日：2004-10-12

申请号：US10011451

申请日：2001-11-07

申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hammerle ,  Eberhart Zrenner ,  Martin Stelzle

发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hammerle ,  Eberhart Zrenner ,  Martin Stelzle

IPC分类号： A61N118

CPC分类号： A61F2/14 ,  A61N1/0543 ,  A61N1/36046 ,  H01L27/14609

摘要： A retina implant, comprises a surface and a plurality of pixel elements disposed on the surface for receiving and converting incoming light energy into electric energy. At least one amplifier is provided in the implant, and a plurality of stimulation electrodes supplied via the at least one amplifier as a function of signals received by the pixel elements. At least one light-sensitive reference element is coupled with the at least one amplifier for controlling amplification thereof as a function of light energy impinging on the at least one reference element.

摘要翻译： 视网膜植入物包括设置在表面上的表面和多个像素元件，用于接收和将入射的光能转换成电能。 在植入物中提供至少一个放大器，以及经由至少一个放大器提供的多个刺激电极作为由像素元件接收的信号的函数。 至少一个光敏参考元件与至少一个放大器耦合，用于控制其作为照射在至少一个参考元件上的光能的函数的放大。

公开(公告)号：US06847847B2

公开(公告)日：2005-01-25

申请号：US10011641

申请日：2001-11-07

申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

IPC分类号： A61F2/14 ,  A61F9/08 ,  A61N1/36

CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/3787

摘要： A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

摘要翻译： 一种视网膜植入物，包括适于植入眼睛内部的芯片，视网膜视网膜与视网膜接触。 该芯片在面向透镜的一侧具有多个像素元件，用于接收投影到视网膜中的图像，以及多个用于刺激视网膜细胞的电极。 植入物还包括用于感应地耦合到其中的电磁能的接收器线圈。 接收器线圈耦合到用于将感应到接收器线圈的交流电压以适于供应芯片的直流电压的装置。 接收器线圈被配置为与芯片分离的部件，并且用于定位在巩膜外的眼球上。 芯片通过连接引线连接到接收器线圈，该连接引线在植入条件下将眼球的内部和外部互连。

公开(公告)号：US20060184245A1

公开(公告)日：2006-08-17

申请号：US11305920

申请日：2005-12-19

申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

IPC分类号： A61F2/14

CPC分类号： A61N1/36046

摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

公开(公告)号：US07751896B2

公开(公告)日：2010-07-06

申请号：US11305920

申请日：2005-12-19

申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

IPC分类号： A61F2/14

CPC分类号： A61N1/36046

摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

公开(公告)号：US20060069416A1

公开(公告)日：2006-03-30

申请号：US11194017

申请日：2005-07-29

申请人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

发明人： Wilfried Nisch ,  Martin Stelzle ,  Heinz-Gerhard Graf ,  Eberhart Zrenner ,  Markus Schubert ,  Hugo Haemmerle

IPC分类号： A61N1/18

CPC分类号： A61N1/36046

摘要： The present invention relates to a retina implant for the functional electrostimulation of a retina as a function of incident light. The retina implant has a stimulation chip that is designed to be implanted in the area of the retina of an eye. It further includes a radiation receiver that provides energy for the stimulation chip as a function of invisible radiation that occurs. In accordance with one aspect of the present invention, the radiation receiver is designed so as to be implanted in the area of the eye in a fashion spatially separated from the stimulation chip. The stimulation chip also has decoupling means in order to separate invisible scattered radiation from impinging visible light.

摘要翻译： 本发明涉及视网膜植入物，用于根据入射光的功能性电刺激视网膜。 视网膜植入物具有被设计成植入眼睛视网膜区域的刺激芯片。 它还包括辐射接收器，其作为发生的不可见辐射的函数为刺激芯片提供能量。 根据本发明的一个方面，辐射接收器设计成以与刺激芯片空间分离的方式植入眼睛区域。 刺激芯片还具有去耦装置，以便将不可见的散射辐射与入射的可见光分开。

公开(公告)号：US07272447B2

公开(公告)日：2007-09-18

申请号：US10825071

申请日：2004-04-15

申请人： Alfred Stett ,  Wilfried Nisch ,  Martin Stelzle ,  Eberhart Zrenner

发明人： Alfred Stett ,  Wilfried Nisch ,  Martin Stelzle ,  Eberhart Zrenner

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61N1/08

CPC分类号： A61N1/0543 ,  A61N1/36046

摘要： An electrode arrangement for electrical stimulation of biological material has at least one stimulation electrode via which the biological material can be fed a stimulus signal. Furthermore, a counter electrode is present which forms a counter pole to the stimulation electrode, one sensor electrode is provided with the aid of which it is possible to determine a polarization voltage across the stimulation electrode.

摘要翻译： 用于电刺激生物材料的电极装置具有至少一个刺激电极，生物材料可以通过该刺激电极被馈送刺激信号。 此外，存在对电极，其形成与刺激电极相反的极极，提供了一个传感器电极，借助于此可以确定刺激电极两端的极化电压。

公开(公告)号：US06989089B2

公开(公告)日：2006-01-24

申请号：US10045380

申请日：2001-10-26

申请人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

发明人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

IPC分类号： G01N27/327 ,  G01N27/447 ,  C12M1/34

CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M35/02 ,  C12M41/46 ,  G01N21/763

摘要： A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.

公开(公告)号：US06315940B1

公开(公告)日：2001-11-13

申请号：US09311780

申请日：1999-05-13

申请人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

发明人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

IPC分类号： G01N2726

CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M35/02 ,  C12M41/46 ,  G01N21/763

摘要： A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.

摘要翻译： 微元件具有多个微元件，其可以被配置为微电极，布置在基板上并且适于与存在于液体环境中的电池接触。 细胞被引导到微电极上，被隔离或机械地吸引到微电极。 可以在电池上施加负压力或流体动力。 还描述了与细胞接触的方法，并且公开了一种用于制造微量元件的方法。