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    System and Method for Intracranial Implantation of Therapeutic or Diagnostic Agents
    1.
    发明申请
    System and Method for Intracranial Implantation of Therapeutic or Diagnostic Agents 有权
    用于治疗或诊断剂的颅内植入的系统和方法

    公开(公告)号：US20090192487A1

    公开(公告)日：2009-07-30

    申请号：US12375139

    申请日：2007-07-18

    申请人： William C. Broaddus ,  Rahul Mahajan ,  George T. Gillies

    发明人： William C. Broaddus ,  Rahul Mahajan ,  George T. Gillies

    IPC分类号： A61B6/12 ,  A61M5/00

    CPC分类号： A61M31/007 ,  A61B6/508 ,  A61B90/11

    摘要： A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.

    摘要翻译： 用于将抗肿瘤剂卡莫司汀或其他类型的诊断或治疗剂递送到患有脑肿瘤的患者的脑中的系统和相关方法包括卡莫司汀化合物的插入装置，颅骨支架和重新配置的几何形状（或 其他材料）优化用于插入装置和最大化的生物降解时间。 插入装置可以是正面装载有卡莫司汀材料（或其他材料）并通过头骨上的安装件插入脑肿瘤的位置，然后卡莫司汀（或其他材料）然后被释放。 应当理解，诊断和/或治疗系统及其相关方法不一定限于受试者的脑部。 它还可以用于器官结构或管状结构，以及其部分和位置。

    System and method for intracranial implantation of therapeutic or diagnostic agents
    2.
    发明授权
    System and method for intracranial implantation of therapeutic or diagnostic agents 有权

    公开(公告)号：US09669198B2

    公开(公告)日：2017-06-06

    申请号：US12375139

    申请日：2007-07-18

    申请人： William C. Broaddus ,  Rahul Mahajan ,  George T. Gillies

    发明人： William C. Broaddus ,  Rahul Mahajan ,  George T. Gillies

    IPC分类号： A61M31/00 ,  A61B90/11 ,  A61B6/00

    CPC分类号： A61M31/007 ,  A61B6/508 ,  A61B90/11

    摘要： A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.

    Coaxial Catheter Systems for Transference of Medium
    4.
    发明申请
    Coaxial Catheter Systems for Transference of Medium 有权
    用于传播介质的同轴导管系统

    公开(公告)号：US20100198137A1

    公开(公告)日：2010-08-05

    申请号：US12760837

    申请日：2010-04-15

    申请人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    发明人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0026 ,  A61M5/007 ,  A61M25/00 ,  A61M25/0045 ,  A61M25/007 ,  A61M27/006 ,  A61M2025/1013

    摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.

    摘要翻译： 公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。 同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量 流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。 类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。

    Means and methods for cytometric therapies
    8.
    发明授权
    Means and methods for cytometric therapies 有权
    细胞疗法的方法和方法

    公开(公告)号：US08406837B2

    公开(公告)日：2013-03-26

    申请号：US12513258

    申请日：2007-11-01

    申请人： George T. Gillies ,  Helen Fillmore ,  William C. Broaddus ,  Boyd M. Evans, III ,  Stephen W. Allison

    发明人： George T. Gillies ,  Helen Fillmore ,  William C. Broaddus ,  Boyd M. Evans, III ,  Stephen W. Allison

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075

    摘要： A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.

    摘要翻译： 一个功能化的尖端被并入到导管中，用于将细胞细胞传递到脑和其他身体部位。 为了在脑中使用，尖端形成具有近端和远端的神经外科探针的一部分。 除了功能化的尖端之外，探针具有至少一个细胞浆液递送腔和沿着探针配置的多个光纤，终止于尖端，以提供监测嫁接的生存力和生理行为所需的光学光学能力 细胞以及细胞环境的某些特征。 还提供了在用于调节递送到患者脑部的细胞数量的反馈和控制系统的上下文中使用的具有本发明公开的类型的细胞计数尖端的神经导管的用途的细节。

    Coaxial catheter systems for transference of medium
    9.
    发明授权
    Coaxial catheter systems for transference of medium 有权
    用于介质转移的同轴导管系统

    公开(公告)号：US08211083B2

    公开(公告)日：2012-07-03

    申请号：US12760837

    申请日：2010-04-15

    申请人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    发明人： William C. Broaddus ,  Zhi-Jian Chen ,  George T. Gillies

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0026 ,  A61M5/007 ,  A61M25/00 ,  A61M25/0045 ,  A61M25/007 ,  A61M27/006 ,  A61M2025/1013

    摘要： A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.

    摘要翻译： 公开了用于递送治疗剂和/或进入体内的大脑组织和身体其他部位，组织和器官的方法，技术和系统，包括脉管系统。 同轴导管的新颖形式提供了一种用于将外管植入大脑中的装置，然后将内管插入外管并对准它们，使得两个管上的孔口将重叠并允许治疗剂的通量 流入大脑，以尽可能减少被捕获的空气的影响，实际上消除了药剂的回流，并避免了额外的损害大脑的潜力，因为只需要一个手术放置外管。 类似地，该方法技术系统可用于从脑，组织和器官中除去流体或其它介质，以最小化逃逸空气或负压的影响。