公开(公告)号：US07317095B2

公开(公告)日：2008-01-08

申请号：US10493540

申请日：2002-10-22

Applicant: William H. Brondyk ,  Xuliang Jiang ,  Robert Campbell

Inventor： William H. Brondyk ,  Xuliang Jiang ,  Robert Campbell

IPC: C07K14/59 ,  C12N15/00 ,  C12N15/63 ,  C12N5/00

CPC classification number: C07K14/59 ,  A61K38/00

Abstract: The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.

Abstract translation: 本发明人设计了具有增加的糖基化和更长半衰期的新型FSH突变体用于诱导人类患者的卵泡发生。 使用本发明的FSH突变体制剂允许使用较低累积剂量的FSH来实现相同或更好的临床结果。

公开(公告)号：US07700112B2

公开(公告)日：2010-04-20

申请号：US10934707

申请日：2004-09-02

Applicant: Louise M. Garone ,  Stephen J. Arkinstall ,  William H. Brondyk ,  Robert K. Campbell ,  Xuliang Jiang ,  Sean D. McKenna ,  Mark Tepper

Inventor： Louise M. Garone ,  Stephen J. Arkinstall ,  William H. Brondyk ,  Robert K. Campbell ,  Xuliang Jiang ,  Sean D. McKenna ,  Mark Tepper

IPC: A61K38/24 ,  C12N15/16 ,  C07H21/04

CPC classification number: C07K14/59

Abstract: A novel FSH mutant with increased glycosylation and longer half-lifes for use in inducing folliculogenesis in human patients is described. The FSH mutant permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.

Abstract translation: 描述了具有增加的糖基化和更长的半衰期用于诱导人类患者卵泡发生的新型FSH突变体。 FSH突变体允许使用较低累积剂量的FSH来实现相同或更好的临床结果。

公开(公告)号：US09567382B2

公开(公告)日：2017-02-14

申请号：US12936659

申请日：2009-04-15

Applicant: Catherine R. O'Riordan ,  William H. Brondyk

Inventor： Catherine R. O'Riordan ,  William H. Brondyk

IPC: C12N15/79 ,  C07K14/47

CPC classification number: C07K14/47

Abstract: The invention is related to methods of producing rod-derived cone viability factor (RdCVF). This invention also relates to the treatment of an ocular disease in a mammal using RdCVF. Also provided are expression vectors for high secreted expression of RdCVF of using nucleotide sequences encoding heterologous signal proteins and optionally markers for furin cleavage.

Abstract translation: 本发明涉及产生棒衍生的锥形存活因子（RdCVF）的方法。 本发明还涉及使用RdCVF治疗哺乳动物的眼部疾病。 还提供了使用编码异源信号蛋白的核苷酸序列和任选的用于弗林蛋白酶切割的标记的RdCVF的高分泌表达的表达载体。

公开(公告)号：US20110034546A1

公开(公告)日：2011-02-10

申请号：US12936659

申请日：2009-04-15

Applicant: Catherine R. O'Riordan ,  William H. Brondyk

Inventor： Catherine R. O'Riordan ,  William H. Brondyk

IPC: A61K31/7088 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  A61P27/02

CPC classification number: C07K14/47

Abstract: The invention is related to methods of producing rod-derived cone viability factor (RdCVF). This invention also relates to the treatment of an ocular disease in a mammal using RdCVF. Also provided are expression vectors for high secreted expression of RdCVF of using nucleotide sequences encoding heterologous signal proteins and optionally markers for furin cleavage.

Abstract translation: 本发明涉及产生棒衍生的锥形存活因子（RdCVF）的方法。 本发明还涉及使用RdCVF治疗哺乳动物的眼部疾病。 还提供了使用编码异源信号蛋白的核苷酸序列和任选的用于弗林蛋白酶切割的标记的RdCVF的高分泌表达的表达载体。