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公开(公告)号：US07005413B1
公开(公告)日：2006-02-28
申请号：US09613591
申请日：2000-07-10
IPC分类号： A61K38/00 , C07K14/51 , C07K14/525 , C07K14/54 , C07K16/46
CPC分类号： A61K38/1793 , A61K38/00 , C07K14/70578 , C07K2319/30
摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis. Methods of treatment are described using the polypeptides in conjunction with various agents, including IL-1 inhibitors, TNF-α inhibitors, and serine protease inhibitors.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。 使用多种结合多种试剂（包括IL-1抑制剂，TNF-α抑制剂和丝氨酸蛋白酶抑制剂）描述治疗方法。
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公开(公告)号：US06369027B1
公开(公告)日：2002-04-09
申请号：US08706945
申请日：1996-09-03
IPC分类号： A61K3818
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06284485B1
公开(公告)日：2001-09-04
申请号：US08795445
申请日：1997-02-06
IPC分类号： C12N121
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06284740B1
公开(公告)日：2001-09-04
申请号：US08974186
申请日：1997-11-18
IPC分类号： A01N4304
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US6015938A
公开(公告)日：2000-01-18
申请号：US974022
申请日：1997-11-18
IPC分类号： A01K67/027 , A61K35/74 , A61K38/00 , A61K48/00 , A61P43/00 , C07K14/705 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/15 , G01N33/53 , C12N5/00
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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公开(公告)号：US07632922B1
公开(公告)日：2009-12-15
申请号：US09718725
申请日：2000-11-22
CPC分类号： C07K16/2878 , C07K14/70578 , C07K2319/30 , G01N2333/7151
摘要： The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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公开(公告)号：US06613544B1
公开(公告)日：2003-09-02
申请号：US08577788
申请日：1995-12-22
IPC分类号： C07K1451
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06288032B1
公开(公告)日：2001-09-11
申请号：US08795446
申请日：1997-02-06
IPC分类号： A61K3818
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor super family and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译： 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US06284728B1
公开(公告)日：2001-09-04
申请号：US08795447
申请日：1997-02-06
IPC分类号： A61K3818
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
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公开(公告)号：US08845583B2
公开(公告)日：2014-09-30
申请号：US11651667
申请日：2007-01-10
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。
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