公开(公告)号：US20050136001A1

公开(公告)日：2005-06-23

申请号：US10901441

申请日：2004-07-29

申请人： William McBride ,  David Goldenberg

发明人： William McBride ,  David Goldenberg

IPC分类号： A61K47/48 ,  A61K49/04 ,  A61K51/04 ,  A61K51/08 ,  C07H3/00 ,  C07K16/30 ,  C07K16/44 ,  A61K51/00 ,  C07K16/46

CPC分类号： C07H3/00 ,  A61K47/64 ,  A61K47/6879 ,  A61K47/6897 ,  A61K49/0433 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0491 ,  A61K51/088 ,  B82Y5/00 ,  C07K16/3007 ,  C07K16/44 ,  C07K2317/55

摘要： Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected molecules, and the conjugates may be useful in diagnostic or therapeutic methods. Particularly, the conjugates may be useful in diagnostic or therapeutic kits.

摘要翻译： 公开了包括氟化碳水化合物分子的新型缀合物和用于合成缀合物的方法。 氟化碳水化合物分子可以包括放射性同位素。 合成缀合物的方法可用于标记所选择的分子，并且缀合物可用于诊断或治疗方法。 特别地，缀合物可用于诊断或治疗试剂盒。

公开(公告)号：US20060228357A1

公开(公告)日：2006-10-12

申请号：US11389358

申请日：2006-03-24

申请人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

发明人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

IPC分类号： C12Q1/70 ,  G01N33/574 ,  A61K39/395 ,  C07K14/82 ,  C07K16/30 ,  C07K14/415 ,  A61K39/00 ,  C07K16/46

CPC分类号： C12N9/12 ,  B82Y5/00 ,  B82Y10/00 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/3007 ,  C07K16/3092 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2319/00 ,  C07K2319/70 ,  C12Y207/11011

摘要： The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor. The precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. Other embodiments concern tetramers comprising a first and second homodimer, which may be identical or different. The disclosed methods and compositions provide a facile and general way to obtain homodimers, homotetramers and heterotetramers of virtually any functionality and/or binding specificity.

公开(公告)号：US20070086942A1

公开(公告)日：2007-04-19

申请号：US11478021

申请日：2006-06-29

申请人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

发明人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

IPC分类号： A61K51/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/554 ,  C07K16/46

CPC分类号： A61K47/48438 ,  A61K31/00 ,  A61K38/00 ,  A61K47/48415 ,  A61K47/48484 ,  A61K47/485 ,  A61K47/48538 ,  A61K47/48546 ,  A61K47/48561 ,  A61K47/48569 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6829 ,  A61K47/6833 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/2851 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/3007 ,  C07K16/3092 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/35 ,  C07K2319/70 ,  C07K2319/74 ,  C12N9/12 ,  C12N9/22 ,  C12N9/96 ,  C12Y207/11001 ,  G01N33/54353 ,  G01N33/588 ,  Y02A50/491

摘要： The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-and-lock (DNL) methodology, which takes advantage of the specific binding interaction between dimerization and docking domains (DDD) and anchoring domains (AD) to form the assembly. In various embodiments, one or more effectors may be attached to a DDD or AD sequence. Complementary AD or DDD sequences may be attached to an adaptor module that forms the core of the bioactive assembly, allowing formation of the assembly through the specific DDD/AD binding interactions. Such assemblies may be attached to a wide variety of effector moieties for treatment, detection and/or diagnosis of a disease, pathogen infection or other medical or veterinary condition.

摘要翻译： 本发明涉及用于制备和使用具有多种功能和/或结合特异性的限定组合物的生物活性组合物的方法和组合物。 在特定的实施方案中，生物活性组件使用对接和锁定（DNL）方法形成，其利用二聚化和对接结构域（DDD）和锚定结构域（AD）之间的特异性结合相互作用形成组件。 在各种实施方案中，一个或多个效应物可以连接到DDD或AD序列。 互补AD或DDD序列可以连接到形成生物活性组件核心的适配器模块，从而允许通过特定的DDD / AD结合相互作用形成组装体。 这些组合物可以连接到各种各样的效应部分，用于治疗，检测和/或诊断疾病，病原体感染或其他医学或兽医病症。

公开(公告)号：US20060140858A1

公开(公告)日：2006-06-29

申请号：US10514632

申请日：2003-05-16

申请人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Gu

发明人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Gu

IPC分类号： A61K49/14 ,  A61K51/00 ,  C07K7/06

CPC分类号： A61K51/1048 ,  A61K47/665 ,  A61K47/6879 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/0215 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00

摘要： The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds the targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the targetable constructs and bi-specific antibodies or antibody fragments, as well as methods for using them.

摘要翻译： 本发明涉及可靶向的构建体，其可以由具有特异性结合靶组织的至少一个臂的双特异性抗体或抗体片段和至少一个特异性结合可靶向构建体的其它臂结合。 可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。 可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。 本发明提供用于产生可靶向构建体和双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

公开(公告)号：US20050261170A1

公开(公告)日：2005-11-24

申请号：US11040114

申请日：2005-01-24

申请人： Hans Hansen ,  William McBride ,  David Goldenberg ,  Edmund Rossi ,  Chien-Hsing Chang

发明人： Hans Hansen ,  William McBride ,  David Goldenberg ,  Edmund Rossi ,  Chien-Hsing Chang

IPC分类号： A61K47/48 ,  A61K48/00 ,  C07H21/02 ,  C07K14/47 ,  C07K14/705 ,  C12N9/22

CPC分类号： C12N9/22 ,  A61K33/24 ,  A61K38/00 ,  A61K38/19 ,  A61K45/06 ,  A61K47/551 ,  C07K14/705 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/473 ,  Y02A50/478 ,  A61K2300/00

摘要： Disclosed are conjugates and complexes that include a folate receptor ligand and one or more therapeutic molecules, such as onconase or a variant thereof such as rapLR1. The conjugates and complexes may be useful as primary therapeutic agents, which may be administered with additional therapeutic or diagnostic agents. Also disclosed are kits that include the conjugates and complexes.

摘要翻译： 公开了包含叶酸受体配体和一种或多种治疗分子（例如onconase或其变体）如rapLR1的缀合物和复合物。 缀合物和复合物可用作主要治疗剂，其可以与另外的治疗剂或诊断剂一起施用。 还公开了包含缀合物和复合物的试剂盒。

公开(公告)号：US20070142296A1

公开(公告)日：2007-06-21

申请号：US11640557

申请日：2006-12-18

申请人： William McBride ,  David Goldenberg

发明人： William McBride ,  David Goldenberg

IPC分类号： A61K38/08 ,  C07K7/06 ,  A61K31/7048 ,  A61K31/704

CPC分类号： C07K5/0815 ,  A61K38/00 ,  A61K47/6897 ,  A61K49/0002 ,  A61K51/109 ,  B82Y5/00 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  Y02A50/411

摘要： The present invention provides compounds of the formula X—R1-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5; or R1(X)-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5, in which X is a hard acid cation chelator, a soft acid cation chelator or Ac—, R1, R2 and R3 are independently selected from a covalent bond or one or more D-amino acids that can be the same or different, Y is a hard acid cation chelator, a soft acid cation chelator or absent, Z is a hard acid cation chelator, a soft acid cation chelator or absent, and A and B are haptens or hard acid cation chelators and can be the same or different, and R4 and R5 are independently selected from the group consisting of hard acid cation chelators, soft acid cation chelators, enzymes, therapeutic agents, diagnostic agents and H. The present invention also provides methods of using these compounds and kits containing the compounds.

摘要翻译： 本发明提供式XR 1 -D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn 或Lys]（B）-R 3（Y）-NR 4 R 5; （X）-D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn或Lys]（ B）-R 3（Y）-NR 4 R 5，其中X是硬酸阳离子螯合剂，软酸阳离子螯合剂 或Ac-，R 1，R 2和R 3独立地选自共价键或一个或多个D氨基酸，其可以 Y是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，Z是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，A和B是半抗原或硬酸阳离子螯合剂， R 4和R 5可以相同或不同，R 4和R 5独立地选自硬酸阳离子螯合剂，软酸阳离子螯合剂，酶，治疗剂， 诊断剂和H.本发明还提供使用这些化合物和含有化合物的试剂盒的方法。

公开(公告)号：US20060228300A1

公开(公告)日：2006-10-12

申请号：US11391584

申请日：2006-03-28

申请人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

发明人： Chien Chang ,  David Goldenberg ,  William McBride ,  Edmund Rossi

IPC分类号： A61K51/00 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/395 ,  A61K47/65 ,  A61K47/6853 ,  A61K51/088 ,  A61K51/1048 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C07K16/283 ,  C07K16/3007 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2319/00 ,  C07K2319/70

摘要： The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first monomer, comprising a dimerization and docking domain attached to a first precursor, and a second monomer comprising an anchoring domain attached to a second precursor. The first and second precursors may be virtually any molecule or structure, such as antibodies, antibody fragments, antibody analogs or mimetics, aptamers, binding peptides, fragments of binding proteins, known ligands for proteins or other molecules, enzymes, detectable labels or tags, therapeutic agents, toxins, pharmaceuticals, cytokines, interleukins, interferons, radioisotopes, proteins, peptides, peptide mimetics, polynucleotides, RNAi, oligosaccharides, natural or synthetic polymeric substances, nanoparticles, quantum dots, organic or inorganic compounds, etc. The disclosed methods and compositions provide a simple, easy to purify way to obtain any binary compound attached to any monomeric compound, or any trinary compound.

公开(公告)号：US20060034759A1

公开(公告)日：2006-02-16

申请号：US11198846

申请日：2005-08-08

申请人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Qu

发明人： David Goldenberg ,  Hans Hansen ,  Shui-on Leung ,  William McBride ,  Zhengxing Qu

IPC分类号： A61K51/00 ,  C07K7/06 ,  C07K16/46

CPC分类号： A61K51/1048 ,  A61K47/665 ,  A61K47/6879 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/0215 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2319/00

摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.

公开(公告)号：US20050025709A1

公开(公告)日：2005-02-03

申请号：US10866180

申请日：2004-06-14

申请人： William McBride ,  David Goldenberg

发明人： William McBride ,  David Goldenberg

IPC分类号： A61K38/00 ,  A61K49/00 ,  C07K5/10 ,  A61K38/16 ,  A61K38/43 ,  C12N9/00 ,  C07F5/00

CPC分类号： C07K5/0815 ,  A61K38/00 ,  A61K47/6897 ,  A61K49/0002 ,  A61K51/109 ,  B82Y5/00 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  Y02A50/411

摘要： The present invention provides compounds of the formula X—R1-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5; or R1(X)-D-[Dpr, Orn or Lys](A)-R2(Z)-D-[Dpr, Orn or Lys](B)—R3(Y)—NR4R5, in which X is a hard acid cation chelator, a soft acid cation chelator or Ac—, R1, R2 and R3 are independently selected from a covalent bond or one or more D-amino acids that can be the same or different, Y is a hard acid cation chelator, a soft acid cation chelator or absent, Z is a hard acid cation chelator, a soft acid cation chelator or absent, and A and B are haptens or hard acid cation chelators and can be the same or different, and R4 and R5 are independently selected from the group consisting of hard acid cation chelators, soft acid cation chelators, enzymes, therapeutic agents, diagnostic agents and H. The present invention also provides methods of using these compounds and kits containing the compounds.

摘要翻译： 本发明提供式XR 1 -D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn或Lys]（B）-R 3的化合物 >（Y）-NR 4 R 5; 或者R 1（X）-D- [Dpr，Orn或Lys]（A）-R 2（Z）-D- [Dpr，Orn或Lys]（B）-R 3（Y） -NR 4 R 5，其中X是硬酸阳离子螯合剂，软酸阳离子螯合剂或Ac-，R 1，R 2和R 3独立地选自共价键 或一个或多个可以相同或不同的D-氨基酸，Y是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，Z是硬酸阳离子螯合剂，软酸阳离子螯合剂或不存在，A B是半抗原或硬酸阳离子螯合剂，可以相同或不同，R 4和R 5独立地选自硬酸阳离子螯合剂，软酸阳离子螯合剂，酶，治疗剂， 诊断剂和H.本发明还提供使用这些化合物和含有化合物的试剂盒的方法。

公开(公告)号：US20050002945A1

公开(公告)日：2005-01-06

申请号：US10776470

申请日：2004-02-11

申请人： William McBride ,  David Goldenberg ,  Carl Noren ,  Hans Hansen

发明人： William McBride ,  David Goldenberg ,  Carl Noren ,  Hans Hansen

IPC分类号： A61K47/48 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  C07K7/06 ,  C07K16/18 ,  C07K16/30 ,  C07K16/44 ,  C07K16/46 ,  A61K39/00

CPC分类号： A61K51/0497 ,  A61K47/665 ,  A61K51/04 ,  A61K51/0455 ,  A61K51/048 ,  A61K51/1048 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K5/06078 ,  C07K5/1013 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06 ,  C07K16/18 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00

摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.

摘要翻译： 公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。 半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。 化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。 效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。 还公开了合成化合物的化合物和/或前体的方法。