公开(公告)号：US07079893B2

公开(公告)日：2006-07-18

申请号：US10765559

申请日：2004-01-24

Applicant: Wilson Greatbatch ,  Jeffrey Deal

Inventor： Wilson Greatbatch ,  Jeffrey Deal

IPC: A61N1/40

CPC classification number: H01M16/00 ,  A61N1/08 ,  A61N1/378 ,  H01M6/16 ,  H01M6/5016 ,  H01M6/5033 ,  H01M10/052 ,  H01M10/0525 ,  H02J7/0054

Abstract: A hybrid battery power source for implantable medical use provides a generally constant low internal resistance during discharge and avoids voltage delays of the type that develop as a result of run down-induced resistance increase in Li/SVO cells. The hybrid battery power source utilizes two batteries or cells, one being a primary cell of relatively high energy density and the other being a secondary cell of relatively low internal resistance that is rechargeable. The primary and secondary cells are connected in a parallel arrangement via a voltage boost/charge control circuit that is powered by the primary cell and adapted to charge the secondary cell while limiting charge/discharge excursions thereof in a manner that optimizes its output for high energy medical device use. The energy storage capacitors of the medical device in which the hybrid battery power source is situated are driven by the secondary cell. The primary cell is used to as an energy source for recharging the secondary cell.

公开(公告)号：US06909915B2

公开(公告)日：2005-06-21

申请号：US10350921

申请日：2003-01-24

Applicant: Wilson Greatbatch ,  Jeffrey Deal

Inventor： Wilson Greatbatch ,  Jeffrey Deal

IPC: A61N1/08 ,  A61N1/378 ,  H01M6/16 ,  H01M6/50 ,  H01M10/052 ,  H01M16/00 ,  H02J7/00 ,  A61N1/40

CPC classification number: H01M16/00 ,  A61N1/08 ,  A61N1/378 ,  H01M6/16 ,  H01M6/5016 ,  H01M6/5033 ,  H01M10/052 ,  H02J7/0054

Abstract: A hybrid battery power source for implantable medical use provides relatively stable resistance during discharge and avoids the voltage delays that develop as a result of variable resistance increase in Li/SVO cells. The hybrid battery power source utilizes two batteries or cells, one being a primary battery of relatively high energy density and the other being a rechargeable secondary battery of low relatively stable internal resistance. The primary and secondary batteries are connected in a parallel arrangement, preferably via an intermediate voltage boost circuit having an inductor and a pulse generating control circuit therein. The energy storage capacitors of the medical device in which the hybrid battery power source is situated are driven in whole or substantial part by the secondary battery. The primary battery is used to as an energy source for recharging the secondary battery. By arranging the two batteries in parallel, with one serving as a primary battery and the other as a rechargeable secondary battery, all the benefits of the defibrillatory impulse will be obtained and the deficiencies arising from variable voltage delay found in prior art implantable power sources will not be present.

Abstract translation: 用于可植入医疗用途的混合电池电源在放电期间提供相对稳定的电阻，并且避免由于Li / SVO电池中可变电阻增加而导致的电压延迟。 混合电池电源使用两个电池或电池，一个是相对较高能量密度的一次电池，另一个是具有低相对稳定内阻的可再充电二次电池。 主电池和二次电池以并联的方式连接，优选地经由其中具有电感器和脉冲发生控制电路的中压升压电路。 混合电池电源所在的医疗装置的储能电容器由二次电池全部或大部分驱动。 主电池用作为二次电池充电的能量源。 通过并联布置两个电池，一个充当一次电池，另一个作为可充电二次电池，将获得除颤脉冲的所有益处，并且在现有技术的可植入电源中发现的可变电压延迟引起的缺陷将会 不存在

公开(公告)号：US20070217163A1

公开(公告)日：2007-09-20

申请号：US11376616

申请日：2006-03-15

Applicant: Wilson Greatbatch ,  Jeffrey Deal

Inventor： Wilson Greatbatch ,  Jeffrey Deal

IPC: H05K7/20

CPC classification number: A61N1/375 ,  A61N1/37211 ,  A61N1/3787

Abstract: An implantable device includes a device case comprising amorphous non-ferrous metal alloy material and having lower electrical conductivity than crystalline atomic structures comprising the same alloy constituents. The generation of eddy currents is thereby reduced and inductive charging and/or telemetry system operation can take place at higher frequencies with a resulting improvement in energy and data transfer efficiency.

Abstract translation: 可植入装置包括包含无定形有色金属合金材料并且具有比包含相同合金成分的结晶原子结构更低导电性的装置壳体。 从而降低了涡流的产生，并且可以在较高频率下进行感应充电和/或遥测系统操作，从而提高了能量和数据传输效率。

公开(公告)号：US07136701B2

公开(公告)日：2006-11-14

申请号：US10727349

申请日：2003-12-03

Applicant: Wilson Greatbatch ,  Jeffrey Deal

Inventor： Wilson Greatbatch ,  Jeffrey Deal

IPC: A61N1/40

CPC classification number: H01M16/00 ,  A61N1/08 ,  A61N1/378 ,  H01M6/16 ,  H01M6/5016 ,  H01M6/5033 ,  H01M10/052 ,  H01M10/0525 ,  H02J7/0054

Abstract: A hybrid battery power source for implantable medical use provides a generally constant low internal resistance during discharge and avoids voltage delays of the type that develop as a result of run down-induced resistance increase in Li/SVO cells. The hybrid battery power source utilizes two batteries or cells, one being a primary cell of relatively high energy density and the other being a secondary cell of relatively low internal resistance that is rechargeable. The primary and secondary cells are connected in a parallel arrangement via a voltage boost/charge control circuit that is powered by the primary cell and adapted to charge the secondary cell while limiting charge/discharge excursions thereof in a manner that optimizes its output for high energy medical device use. The energy storage capacitors of the medical device in which the hybrid battery power source is situated are driven by the secondary cell. The primary cell is used to as an energy source for recharging the secondary cell.

Abstract translation: 用于可植入医疗用途的混合电池电源在放电期间提供通常恒定的低内部电阻，并且避免由于Li / SVO电池的下降引起的电阻增加而发展的类型的电压延迟。 混合电池电源使用两个电池或电池，一个是相对较高能量密度的主电池，另一个是可再充电的内阻相对较低的二次电池。 主电池和次电池通过电压升压/充电控制电路以并联装置连接，该电压升压/充电控制电路由主电池供电并且适于对二次电池充电，同时以优化其高能量输出的方式限制充电/放电偏移 医疗器械使用。 混合电池电源所在的医疗装置的储能电容器由二次电池驱动。 主电池用作再次充电二次电池的能量源。

公开(公告)号：US20060111752A1

公开(公告)日：2006-05-25

申请号：US10994565

申请日：2004-11-22

Applicant: Wilson Greatbatch ,  Jeffrey Deal

Inventor： Wilson Greatbatch ,  Jeffrey Deal

IPC: A61N1/378

CPC classification number: A61N1/3975 ,  A61N1/3787 ,  H01M10/052 ,  H01M10/44 ,  H01M10/441 ,  H01M10/46

Abstract: A high energy battery power source suitable for use in an implantable medical device includes an input, an output, and two or more battery modules each comprising two or more battery cells. The battery cells are of relatively low voltage and permanently configured within each battery module in an electrically parallel arrangement in order to provide a desired current discharge level needed to achieve high-energy output. A switching system configures the battery modules between a first configuration wherein the battery modules are electrically connected in parallel to each other and to the input in order to receive charging energy at the relatively low voltage, and a second configuration wherein the battery modules are electrically connected in series to each other in order to provide to the output a relatively high voltage corresponding to the number of battery modules at a current level corresponding to the number of battery cells in a single battery module.

Abstract translation: 适用于可植入医疗装置的高能量电池电源包括输入端，输出端和两个或更多个电池模块，每个电池模块包括两个或多个电池单元。 电池单元具有相对低的电压并且以电并联的方式永久地配置在每个电池模块内，以便提供实现高能量输出所需的期望的电流放电水平。 交换系统将电池模块配置在第一配置之间，其中电池模块彼此并联电连接到输入端，以便在相对低的电压下接收充电能量;以及第二配置，其中电池模块电连接 彼此串联，以向输出提供对应于在单个电池模块中与电池单元的数量相对应的当前电平的电池模块的数量的相对高的电压。

公开(公告)号：US07020519B2

公开(公告)日：2006-03-28

申请号：US10407916

申请日：2003-04-04

Applicant: Wilson Greatbatch ,  Jeffrey Deal

Inventor： Wilson Greatbatch ,  Jeffrey Deal

IPC: A61N1/18

CPC classification number: H01M16/00 ,  A61N1/378 ,  H01M6/16 ,  H01M6/5016 ,  H01M6/5033 ,  H01M10/052 ,  H01M10/0525 ,  H02J7/0054

Abstract: A hybrid battery power source for implantable medical use provides a generally constant low internal resistance during discharge and avoids voltage delays of the type that develop as a result of run down-induced resistance increase in Li/SVO cells. The hybrid battery power source utilizes two batteries or cells, one being a primary cell of relatively high energy density and the other being a secondary cell of relatively low internal resistance that is rechargeable. The primary and secondary cells are connected in a parallel arrangement via a voltage boost/charge control circuit that is powered by the primary cell and adapted to charge the secondary cell while limiting charge/discharge excursions thereof in a manner that optimizes its output for high energy medical device use. The energy storage capacitors of the medical device in which the hybrid battery power source is situated are driven by the secondary cell. The primary cell is used to as an energy source for recharging the secondary cell.

公开(公告)号：US20060129192A1

公开(公告)日：2006-06-15

申请号：US11274926

申请日：2005-11-15

Applicant: Wilson Greatbatch ,  Jeffrey Deal ,  Glenn Thomas

Inventor： Wilson Greatbatch ,  Jeffrey Deal ,  Glenn Thomas

IPC: A61N1/39

CPC classification number: A61N1/378 ,  A61N1/375 ,  A61N1/3956

Abstract: A high energy battery power source suitable for use in an implantable medical device includes an input, an output, and two or more battery modules each comprising two or more battery cells. The battery cells are of relatively low voltage and permanently configured within each battery module in an electrically parallel arrangement in order to provide a desired current discharge level needed to achieve high-energy output. A switching system configures the battery modules between a first configuration wherein the battery modules are electrically connected in parallel to each other and to the input in order to receive charging energy at the relatively low voltage, and a second configuration wherein the battery modules are electrically connected in series to each other in order to provide to the output a relatively high voltage corresponding to the number of battery modules at a current level corresponding to the number of battery cells in a single battery module. An alternate embodiment permanently connects the battery modules in series so that no switching system is need for discharging and charging. A technique that provides for the control of discharge voltages on a pulse-to-pulse basis is also disclosed.

Abstract translation: 适用于可植入医疗装置的高能量电池电源包括输入端，输出端和两个或更多个电池模块，每个电池模块包括两个或多个电池单元。 电池单元具有相对低的电压并且以电并联的方式永久地配置在每个电池模块内，以便提供实现高能量输出所需的期望的电流放电水平。 交换系统将电池模块配置在第一配置之间，其中电池模块彼此并联电连接到输入端，以便在相对低的电压下接收充电能量;以及第二配置，其中电池模块电连接 彼此串联，以向输出提供对应于在单个电池模块中与电池单元的数量相对应的当前电平的电池模块的数量的相对高的电压。 一个替代实施例将串联的电池模块永久连接，使得不需要用于放电和充电的开关系统。 还公开了一种提供脉冲对脉冲的放电电压控制的技术。

公开(公告)号：US06988001B2

公开(公告)日：2006-01-17

申请号：US10283530

申请日：2002-10-30

Applicant: Wilson Greatbatch ,  Michael L. Weiner

Inventor： Wilson Greatbatch ,  Michael L. Weiner

IPC: A61N1/362

CPC classification number: A61N1/056 ,  A61N1/0565

Abstract: A hermetic component housing for use with a photonic catheter connected to a photonic pacemaker or other medical system designed for compatibility with Magnetic Resonance Imaging (MRI) procedures. The hermetic housing includes a housing body having a proximal end and a distal end. The body is formed with a hermetically sealed interior for carrying one or more electrical and/or optical components therein. The proximal end of the body is adapted to mount to a distal end of a photonic catheter carrying a fiber optic element or bundle. A hermetic terminal is provided to allow the fiber optic element or bundle to communicate with the body interior. The body can be adapted to mount (or function as) one or more electrodes designed for delivering or sensing electrical signals to body tissue, or it may be adapted to mount no electrodes. The component housing may be implemented by itself at the distal end of the photonic catheter, or it may be used in conjunction with other housings of like or different construction.

公开(公告)号：US5324643A

公开(公告)日：1994-06-28

申请号：US739718

申请日：1991-07-29

Applicant: Wilson Greatbatch ,  John C. Sanford

Inventor： Wilson Greatbatch ,  John C. Sanford

IPC: A61K48/00 ,  C07K14/15 ,  C07K14/155 ,  C12N15/113 ,  C12N15/867 ,  C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  C12N5/10

CPC classification number: C12N15/1131 ,  C07K14/005 ,  C12N15/1132 ,  C12N15/86 ,  A61K48/00 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/15022 ,  C12N2740/16043

Abstract: In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or homologous, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting retroviral replication and/or interfering with assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using cells upon which resistance to infection has been conferred.

Abstract translation: 根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。 所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，所述多核苷酸指导宿主细胞内的RNA，所述RNA是a）与取决于靶区域互补或同源的RNA与一个或多个核酸序列内的核酸序列 逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，有效地抑制逆转录病毒复制和/或干扰组装成病毒颗粒。 还公开了使用其上赋予抗感染性的细胞的治疗方法。

公开(公告)号：US4385439A

公开(公告)日：1983-05-31

申请号：US161058

申请日：1980-06-19

Applicant: Ralph T. Mead ,  Frank W. Rudolph ,  Norbert W. Frenz, Jr. ,  Wilson Greatbatch

Inventor： Ralph T. Mead ,  Frank W. Rudolph ,  Norbert W. Frenz, Jr. ,  Wilson Greatbatch

IPC: H01M2/06 ,  H01M6/18 ,  H01M2/36

CPC classification number: H01M2/065 ,  H01M6/182 ,  Y10T29/49108 ,  Y10T29/4911

Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The anode operative surface is provided with a coating of an organic electron donor material. The anode conductor is enclosed within the combination of an insulator element within the casing, an isolator element between the insulator and the conductor, and a ferrule having one end within the insulator and the other end extending from the casing. During assembly, the cathode material is introduced in heated form and a filling element is employed which serves to keep the edge of the casing open end clean to facilitate subsequent welding of a lid to the casing.

Abstract translation: 一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极 与壳体和锂元素。 阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。 阳极工作表面设置有有机电子给体材料的涂层。 阳极导体封装在壳体内的绝缘体元件，绝缘体和导体之间的绝缘元件以及绝缘体内的一端和从壳体延伸的另一端的套圈之间。 在组装期间，阴极材料以加热形式引入，并且使用填充元件，其用于保持壳体的边缘开口端清洁以便于将盖子随后焊接到壳体。