公开(公告)号：US20240228931A9

公开(公告)日：2024-07-11

申请号：US17769549

申请日：2020-10-12

Applicant: Wisconsin Alumni Research Foundation

Inventor： Zhenqiang Ma ,  Inkyu Lee ,  Juhwan Lee ,  Michael Phillips ,  David Gamm ,  Shaoqin Gong

IPC: C12M1/12 ,  C12N5/0793

CPC classification number: C12M25/14 ,  C12N5/062 ,  C12N2533/30

Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.

公开(公告)号：US20240132823A1

公开(公告)日：2024-04-25

申请号：US17769549

申请日：2020-10-11

Applicant: Wisconsin Alumni Research Foundation

Inventor： Zhenqiang Ma ,  Inkyu Lee ,  Juhwan Lee ,  Michael Phillips ,  David Gamm ,  Shaoqin Gong

IPC: C12M1/12 ,  C12N5/0793

CPC classification number: C12M25/14 ,  C12N5/062 ,  C12N2533/30

Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.

公开(公告)号：US20200010799A1

公开(公告)日：2020-01-09

申请号：US16506471

申请日：2019-07-09

Applicant: Wisconsin Alumni Research Foundation

Inventor： Zhenqiang Ma ,  Juhwan Lee ,  Yei Hwan Jung ,  Michael Phillips ,  David Gamm ,  Shaoqin Gong ,  Inkyu Lee

IPC: C12N5/0793

Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one cube-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one cube-shaped reservoir.