公开(公告)号：US20240335392A1

公开(公告)日：2024-10-10

申请号：US18580703

申请日：2022-07-21

Applicant: University of Virginia Patent Foundation ,  WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： Kenneth Craig Kent ,  Liang-Wang Guo ,  Bowen Wang ,  Takuro Shirasu ,  Shaoqin Gong ,  Yi Zhao

IPC: A61K9/51 ,  A61K31/517 ,  A61P9/14

CPC classification number: A61K9/5176 ,  A61K9/5146 ,  A61K31/517 ,  A61P9/14

Abstract: In one aspect, the disclosure relates to nanoclusters comprising cores comprising self-assembled unimolecular nanoparticles and biomimetic membrane coatings surrounding the cores, methods of making the same, and methods of treating and preventing restenosis using same. In some embodiments, the nanoclusters can contain an anti-restenotic drug. In one embodiment, the polymers and/or copolymers of the unimolecular nanoparticles can contain a hydrophobic group such as, for example, a phenylboronic ester. In a further embodiment, the biomimetic membrane can localize the nanoclusters at sites of vascular damage, at which time reactive oxygen species (ROS) at the sites of vascular damage cleave the hydrophobic groups from the polymers and/or copolymers, increasing hydrophilicity of the polymers and/or copolymers and allowing for greater tissue penetration of the de-clustered nanoclusters and nanoparticles.

公开(公告)号：US20160193390A1

公开(公告)日：2016-07-07

申请号：US14987038

申请日：2016-01-04

Applicant: Wisconsin Alumni Research Foundation

Inventor： Lian-Wang Guo ,  Kenneth Craig Kent ,  William L. Murphy ,  Xiaohua Yu

IPC: A61L29/16 ,  A61L29/06 ,  A61L29/14 ,  A61M25/00

CPC classification number: A61M25/0043 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61M2025/0057

Abstract: A perivascular delivery system and method are provided for preventing the development of restenosis of a blood vessel. The perivascular delivery system includes a sheath having inner face engageable with an outer surface of the blood vessel and first and second ends. The sheath is fabricated from a bioresorbable polymer. An anti-proliferative drug is loaded into the sheath. The anti-proliferative drug is delivered from the sheath to the blood vessel over time.

Abstract translation: 提供了一种血管周围输送系统和方法，用于防止血管再狭窄的发展。 血管周围输送系统包括具有可与血管的外表面接合的内表面的护套以及第一和第二端。 护套由生物可再吸收的聚合物制成。 将抗增殖药物装入鞘中。 随着时间的推移，抗增殖药物从皮肤递送到血管。