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公开(公告)号：US10745739B2
公开(公告)日：2020-08-18
申请号：US15918357
申请日：2018-03-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Siyoung Choi , Xiaohua Yu
Abstract: Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform.
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公开(公告)号：US11628227B2
公开(公告)日：2023-04-18
申请号：US16626971
申请日：2018-07-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Andrew Salim Khalil , Xiaohua Yu
Abstract: Disclosed are formulations for providing a therapeutic bioactive polypeptide to injured tissue. Formulations include mineral coated microparticles wherein a polynucleotide is adsorbed to the mineral layer. Other formulations include a carrier including mineral coated microparticles wherein mineral coated microparticles include a polynucleotide. Also disclosed are methods for sustained delivery of a bioactive polypeptide and methods for treating chronic wounds using a formulation for providing sustained delivery of the bioactive peptide.
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公开(公告)号：US20210353549A1
公开(公告)日：2021-11-18
申请号：US17379351
申请日：2021-07-19
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Andrew Salim Khalil , Xiaohua Yu
Abstract: Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonucleic acid, and an interferon binding protein. Ribonucleic acids and interferon binding proteins can be adsorbed to the mineral layer, can be incorporated into the mineral Layer, and combinations thereof. Also disclosed are methods for co-delivery of ribonucleic acids and interferon binding proteins and methods for treating inflammatory diseases using mineral coated microparticles having a mineral layer to provide co-delivery of ribonucleic acids and interferon binding proteins.
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公开(公告)号：US09951374B2
公开(公告)日：2018-04-24
申请号：US13769993
申请日：2013-02-19
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Siyoung Choi , Xiaohua Yu
Abstract: Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform.
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公开(公告)号：US20160193390A1
公开(公告)日：2016-07-07
申请号：US14987038
申请日：2016-01-04
Applicant: Wisconsin Alumni Research Foundation
Inventor： Lian-Wang Guo , Kenneth Craig Kent , William L. Murphy , Xiaohua Yu
CPC classification number: A61M25/0043 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/416 , A61M2025/0057
Abstract: A perivascular delivery system and method are provided for preventing the development of restenosis of a blood vessel. The perivascular delivery system includes a sheath having inner face engageable with an outer surface of the blood vessel and first and second ends. The sheath is fabricated from a bioresorbable polymer. An anti-proliferative drug is loaded into the sheath. The anti-proliferative drug is delivered from the sheath to the blood vessel over time.
Abstract translation: 提供了一种血管周围输送系统和方法，用于防止血管再狭窄的发展。 血管周围输送系统包括具有可与血管的外表面接合的内表面的护套以及第一和第二端。 护套由生物可再吸收的聚合物制成。 将抗增殖药物装入鞘中。 随着时间的推移，抗增殖药物从皮肤递送到血管。
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Patent Agency Ranking
公开(公告)号：US11779542B2
公开(公告)日：2023-10-10
申请号：US17379351
申请日：2021-07-19
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Andrew Salim Khalil , Xiaohua Yu
CPC classification number: A61K9/501 , A61K38/162 , C12N15/88
Abstract: Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonucleic acid, and an interferon binding protein. Ribonucleic acids and interferon binding proteins can be adsorbed to the mineral layer, can be incorporated into the mineral Layer, and combinations thereof. Also disclosed are methods for co-delivery of ribonucleic acids and interferon binding proteins and methods for treating inflammatory diseases using mineral coated microparticles having a mineral layer to provide co-delivery of ribonucleic acids and interferon binding proteins.
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7.发明申请公开(公告)号：US20140235498A1
公开(公告)日：2014-08-21
申请号：US13769993
申请日：2013-02-19
Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
Inventor： William L. Murphy , Siyoung Choi , Xiaohua Yu
Abstract: Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform.
Abstract translation: 公开了细胞转染和调节细胞行为的方法。 更具体地说，本公开内容涉及非病毒细胞转染的方法，并且使用允许增强细胞转染的矿物涂层调节细胞行为。 矿物涂层结合多核苷酸并提供钙和磷酸根离子来增强转染。 本公开还提供用于筛选细胞的非病毒转染的高通量平台。 本公开的方法还提供有利的多核苷酸递送平台，因为矿物涂层可以在使用高通量筛选平台进行专门开发之后沉积在各种医疗装置材料上。
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公开(公告)号：US20200170958A1
公开(公告)日：2020-06-04
申请号：US16626973
申请日：2018-07-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Andrew Salim Khalil , Xiaohua Yu
Abstract: Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonucleic acid, and an interferon binding protein. Ribonucleic acids and interferon binding proteins can be adsorbed to the mineral layer, can be incorporated into the mineral layer, and combinations thereof. Also disclosed are methods for co-delivery of ribonucleic acids and interferon binding proteins and methods for treating inflammatory diseases using mineral coated microparticles having a mineral layer to provide co-delivery of ribonucleic acids and interferon binding proteins.
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公开(公告)号：US11065208B2
公开(公告)日：2021-07-20
申请号：US16626973
申请日：2018-07-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Andrew Salim Khalil , Xiaohua Yu
Abstract: Disclosed are compositions and methods for the co-delivery of ribonucleic acids and interferon binding proteins. Compositions include mineral coated microparticles having a mineral layer, a ribonucleic acid, and an interferon binding protein. Ribonucleic acids and interferon binding proteins can be adsorbed to the mineral layer, can be incorporated into the mineral layer, and combinations thereof. Also disclosed are methods for co-delivery of ribonucleic acids and interferon binding proteins and methods for treating inflammatory diseases using mineral coated microparticles having a mineral layer to provide co-delivery of ribonucleic acids and interferon binding proteins.
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公开(公告)号：US20180201972A1
公开(公告)日：2018-07-19
申请号：US15918357
申请日：2018-03-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： William L. Murphy , Siyoung Choi , Xiaohua Yu
Abstract: Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform.
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