公开(公告)号：US20160193390A1

公开(公告)日：2016-07-07

申请号：US14987038

申请日：2016-01-04

Applicant: Wisconsin Alumni Research Foundation

Inventor： Lian-Wang Guo ,  Kenneth Craig Kent ,  William L. Murphy ,  Xiaohua Yu

IPC: A61L29/16 ,  A61L29/06 ,  A61L29/14 ,  A61M25/00

CPC classification number: A61M25/0043 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61M2025/0057

Abstract: A perivascular delivery system and method are provided for preventing the development of restenosis of a blood vessel. The perivascular delivery system includes a sheath having inner face engageable with an outer surface of the blood vessel and first and second ends. The sheath is fabricated from a bioresorbable polymer. An anti-proliferative drug is loaded into the sheath. The anti-proliferative drug is delivered from the sheath to the blood vessel over time.

Abstract translation: 提供了一种血管周围输送系统和方法，用于防止血管再狭窄的发展。 血管周围输送系统包括具有可与血管的外表面接合的内表面的护套以及第一和第二端。 护套由生物可再吸收的聚合物制成。 将抗增殖药物装入鞘中。 随着时间的推移，抗增殖药物从皮肤递送到血管。

公开(公告)号：US10668017B2

公开(公告)日：2020-06-02

申请号：US15674293

申请日：2017-08-10

Applicant: Wisconsin Alumni Research Foundation

Inventor： K. Craig Kent ,  Shaoqin Gong ,  Xudong Shi ,  Guojun Chen ,  Lian-Wang Guo

IPC: A61K9/107 ,  A61K31/436 ,  A61K47/34 ,  A61K9/06 ,  A61K9/51

Abstract: The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers.

公开(公告)号：US20150011492A1

公开(公告)日：2015-01-08

申请号：US14322630

申请日：2014-07-02

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION

Inventor： F. Michael Hoffmann ,  K. Craig Kent ,  Shakti Goel ,  Lian-Wang Guo ,  Toshio Takayama

IPC: A61K31/704 ,  A61F2/82 ,  A61K31/517 ,  A61K31/436 ,  A61K31/047

CPC classification number: A61K31/704 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/047 ,  A61K31/05 ,  A61K31/436 ,  A61K31/517 ,  A61K47/10 ,  A61K47/34 ,  A61K2300/00

Abstract: The present invention relates generally to the pathology of restenosis. In particular, provided herein are devices comprising a compound that selectively decreasing smooth muscle cell proliferation without a substantial decrease in endothelial cell proliferation. Also provided are methods of using such devices to treat, prevent, or reduce vascular disease or the likelihood of restenosis following angioplasty.

Abstract translation: 本发明一般涉及再狭窄的病理学。 特别地，本文提供了包含选择性地降低平滑肌细胞增殖而不显着降低内皮细胞增殖的化合物的装置。 还提供了使用这种装置治疗，预防或减少血管疾病或血管成形术后再狭窄的可能性的方法。