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14 条记录 (耗时 0.027 秒)

    Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives
    3.
    发明授权
    Nonionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives 失效
    非离子型5-C取代的2,4,6-三碘代邻苯二甲酸衍生物

    公开(公告)号：US5047228A

    公开(公告)日：1991-09-10

    申请号：US318454

    申请日：1989-03-02

    申请人： Heinz Gries ,  Heinrich Pfeiffer ,  Ulrich Speck ,  Wolfgang Mutzel

    发明人： Heinz Gries ,  Heinrich Pfeiffer ,  Ulrich Speck ,  Wolfgang Mutzel

    IPC分类号： C07C69/80 ,  A61K49/04 ,  C07C63/68 ,  C07C67/00 ,  C07C69/76 ,  C07C231/00 ,  C07C231/02 ,  C07C231/06 ,  C07C233/65 ,  C07C233/68 ,  C07C233/69 ,  C07C237/30 ,  C07C237/32

    CPC分类号： C07C233/69

    摘要： Nonionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --COOR.sub.3, --CH.sub.2 NHR.sub.7 or --CH.sub.2 OH; Y is --1R.sub.1 R.sub.2 or --OR.sub.3 ; and Z is --NR.sub.1 R.sub.2, --NHR.sub.7 or --OR.sub.3 ; and wherein R.sub.1 R.sub.2 and R.sub.3 in X, Y or Z, and R.sub.7 in X and Z, are identical or different, R.sub.1 and R.sub.2, and each is hydrogen, C.sub.1-6 -alkyl or C.sub.2-8 - alkyl substituted by 1-5 OH groups and/or by a C.sub.1-3 -alkoxy group; R.sub.3 is C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-2 OH groups and/or by a C.sub.1-3 -alkoxy group; and R.sub.7 is an acyl group of a C.sub.2-5 OH group and/or by a C.sub.1-3 -alkoxy group are highly advantageous X-ray contrast agents.

    摘要翻译： 其中X为-CONR1R2，-COOR3，-CH2NHR7或-CH2OH的式（I）的非离子化合物; Y为-1R1R2或-OR3; 并且Z是-NR 1 R 2，-NHR 7或-OR 3; 并且其中X，Y或Z中的R 1和R 3以及X和Z中的R 7相同或不同，R 1和R 2各自为氢，C 1-6 - 烷基或被1-5 OH取代的C 2-8 - 烷基 基团和/或被C 1-3 - 烷氧基取代; R3是被1-2个OH基团和/或被C1-3烷氧基取代的C 1-4 - 烷基或C 2-4 - 烷基; R7是C2-5OH基和/或C1-3烷氧基的酰基是非常有利的X射线造影剂。

    Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides), their preparation, and x-ray contrast media containing same
    5.
    发明授权
    Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides), their preparation, and x-ray contrast media containing same 失效
    不对称取代的二羧酸 - 双 - （2,4,6-三碘 - 酰苯胺），其制备物和含有它们的X射线造影剂

    公开(公告)号：US4395391A

    公开(公告)日：1983-07-26

    申请号：US324368

    申请日：1981-11-24

    申请人： Heinrich Pfeiffer ,  Wolfgang Mutzel ,  Ulrich Speck

    发明人： Heinrich Pfeiffer ,  Wolfgang Mutzel ,  Ulrich Speck

    IPC分类号： A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/00 ,  C07C233/30 ,  C07C235/16 ,  C07C101/68

    CPC分类号： C07C233/00 ,  A61K49/04 ,  C07C233/30

    摘要： Unsymmetrically substituted dicarboxylic-acid-bis-(2,4,6-triiodo-anilides) of formula I ##STR1## wherein X is straight-chain or branched alkylene interrupted by one or more oxygen atoms,R.sup.1 is --NHacyl, --CH.sub.2 NHacyl, or --CONHR.sup.3 wherein R.sup.3 is hydrogen or a lower straight-chain or branched optionally mono- or poly-hydroxylated, alkyl residue, and where any hydroxyl groups present may be functionally modified, andR.sup.2 is hydrogen or lower alkyl, and their salts,are extraordinarily well suited, in view of their good pharmacological and physico-chemical properties, as water-soluble x-ray contrast media for all fields of application, in particular for i.v. cholegraphy and for computer tomography.

    摘要翻译： 式（I）的不对称取代的二羧酸 - 双 - （2,4,6-三碘 - 酰苯胺）其中X是被一个或多个氧原子间隔的直链或支链亚烷基，R 1是-NHacyl， -CH 2 N-酰基或-CONHR 3，其中R 3是氢或低级直链或支链任选的单羟基化或多羟基化的烷基残基，并且其中存在的任何羟基可以被功能性修饰，并且R 2是氢或低级烷基， 盐，由于其良好的药理学和物理化学性质，特别适用于所有应用领域的水溶性x射线造影剂，特别适用于iv 精神科和计算机断层扫描。

    Triiodinated aminoacetamido isophthalamide x-ray contrast agents
    9.
    发明授权
    Triiodinated aminoacetamido isophthalamide x-ray contrast agents 失效
    三碘代氨基乙酰氨基间苯二胺X射线造影剂

    公开(公告)号：US4283381A

    公开(公告)日：1981-08-11

    申请号：US167597

    申请日：1980-07-11

    申请人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    发明人： Ulrich Speck ,  Erich Klieger ,  Wolfgang Mutzel

    IPC分类号： A61K49/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C237/46 ,  C07D209/48 ,  C07C103/183 ,  C07C103/50

    CPC分类号： C07D209/48

    摘要： Compounds of the formula ##STR1## wherein X is alkylene, optionally substituted by hydroxy, methoxy or amino;R.sup.1 is hydrogen or C.sub.1-4 alkyl;R.sup.2 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.3 is hydrogen, C.sub.1-4 alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.4 is hydrogen, C.sub.1-4 -alkyl, or C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.5 is C.sub.2-4 -alkyl substituted by 1-3 OH groups;R.sup.6 is hydrogen, C.sub.1-4 -alkyl or C.sub.2-4 -alkyl substituted by 1-3 OH groups; andR.sup.7 is C.sub.2-4 -alkyl substituted by 1-3 OH groups,or a salt thereof with an acidare useful as opaquing agents in x-ray contrast media.

    摘要翻译： 式（I）的化合物其中X为亚烷基，任选被羟基，甲氧基或氨基取代; R1是氢或C1-4烷基; R2是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R3是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R4是氢，C1-4烷基或被1-3个OH基取代的C2-4-烷基; R5是被1-3个OH基取代的C2-4-烷基; R6是氢，C1-4烷基或被1-3个OH基取代的C2-4烷基; 并且R 7为被1-3个OH基取代的C 2-4烷基，或其与酸的盐可用作x射线造影剂中的不透明剂。

    3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents
    10.
    发明授权
    3-Substituted 2,4,6-trihalogenated benzamides as sweetening agents 失效
    3-取代的2,4,6-三卤代苯甲酰胺作为甜味剂

    公开(公告)号：US4522839A

    公开(公告)日：1985-06-11

    申请号：US554654

    申请日：1983-11-23

    申请人： Heinz Gries ,  Wolfgang Mutzel

    发明人： Heinz Gries ,  Wolfgang Mutzel

    IPC分类号： A23L27/30 ,  C07C233/00 ,  A23L1/236

    CPC分类号： C07C255/00 ,  A23L27/30

    摘要： The 3-substituted 2,4,6-trihalogenated benzamides having the formula I ##STR1## wherein Hal is chlorine, bromine, or iodine andZ is a carboxyl group or the group ##STR2## wherein P is 1 and L is 0 or 1, with the proviso that L is 0 when K is 0;K is 0, 2, 3 or 4;M is 0, 1, 2 or 3;N is 0 or 1;X is a hydrogen atom;Y is a hydrogen atom or a lower alkyl group of 1-4 carbon atoms, or when either M or N is other than 0, a hydroxy group, a C.sub.1-6 alkoxy group or a C.sub.1-4 acyloxy group, or when N is 1 and M is other than 0, X and Y together represent an additional carbon-carbon bond; orP and L are each 0;K is 0, 2, 3 or 4;M is 0, 1, 2 or 3;N is 0 or 1;X is a hydrogen atom;Y is a hydrogen atom, a lower alkyl group of 1-4 carbon atoms, a hydroxy group, a C.sub.1-6 alkoxy group, a C.sub.1-4 acyloxy group or, when N is 1, X and Y together represent an additional carbon-carbon bond; and salts thereof with inorganic bases, exhibit an extraordinarily high sweetening power and are excellent substitutes for natural sweetening agents.

    摘要翻译： 具有式I的3-取代的2,4,6-三卤代苯甲酰胺，其中Hal是氯，溴或碘，Z是羧基或基团，其中P是1，L是0或1 条件是当K为0时L为0; K为0,2,3或4; M为0,1,2或3; N为0或1; X是氢原子; Y是氢原子或1-4个碳原子的低级烷基，或当M或N不是0时，羟基，C1-6烷氧基或C1-4酰氧基，或当N为 1和M不是0，X和Y一起代表额外的碳 - 碳键; 或P和L各自为0; K为0,2,3或4; M为0,1,2或3; N为0或1; X是氢原子; Y是氢原子，1-4个碳原子的低级烷基，羟基，C1-6烷氧基，C1-4酰氧基，或当N是1时，X和Y一起代表另外的碳 - 碳键; 及其与无机碱的盐，表现出极高的甜味力，并且是天然甜味剂的优良替代品。