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    ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION
    1.
    发明申请
    ABUSE RESISTANT MELT EXTRUDED FORMULATION HAVING REDUCED ALCOHOL INTERACTION 审中-公开
    具有降低酒精相互作用的抗菌熔体挤压配方

    公开(公告)号：US20100172989A1

    公开(公告)日：2010-07-08

    申请号：US12631010

    申请日：2009-12-04

    申请人： Wolfgang Roth ,  Alexander Burst ,  Martina Zietsch ,  Wei Liu ,  Sandeep Dutta

    发明人： Wolfgang Roth ,  Alexander Burst ,  Martina Zietsch ,  Wei Liu ,  Sandeep Dutta

    IPC分类号： A61K9/14 ,  A61K31/485 ,  A61P25/04

    CPC分类号： A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2095 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/485

    摘要： The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient. Most preferably, the dosage form includes verapamil. These formulations have reduced potential for abuse. In another formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

    摘要翻译： 本发明涉及用于口服给药的组合物。 本发明优选包含至少一种用于递送具有在醇中倾倒剂量的药物的药物递送组合物，制备这些剂型的相关方法和治疗有需要的患者的方法包括将本发明组合物施用于患者 。 最优选地，剂型包括维拉帕米。 这些制剂减少了滥用的可能性。 在另一种制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。 本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

    FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS
    3.
    发明申请
    FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS 审中-公开
    非对称性和限制性阿片类药物的制剂

    公开(公告)号：US20090022798A1

    公开(公告)日：2009-01-22

    申请号：US11780625

    申请日：2007-07-20

    申请人： Joerg Rosenberg ,  Gerd H. Woehrle ,  Thomas Y. Kessler ,  Joerg Breitenbach ,  Salih Durak ,  Friedrich W. Richter ,  Wei Liu ,  Sandeep Dutta

    发明人： Joerg Rosenberg ,  Gerd H. Woehrle ,  Thomas Y. Kessler ,  Joerg Breitenbach ,  Salih Durak ,  Friedrich W. Richter ,  Wei Liu ,  Sandeep Dutta

    IPC分类号： A61K9/24 ,  A61K31/485 ,  A61K47/30 ,  A61P25/04 ,  A61K9/20

    CPC分类号： A61K9/28 ,  A61K9/0053 ,  A61K9/209 ,  A61K31/167 ,  A61K31/192 ,  A61K31/485 ,  A61K2300/00

    摘要： The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

    摘要翻译： 本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。 这些制剂减少了滥用的可能性。 在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。 本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

    FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS
    5.
    发明申请
    FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS 审中-公开
    非对称性和限制性阿片类药物的制剂

    公开(公告)号：US20110229526A1

    公开(公告)日：2011-09-22

    申请号：US12984373

    申请日：2011-01-04

    申请人： Joerg Rosenberg ,  Gerd H. Woehrle ,  Thomas Y. Kessler ,  Joerg Breitenbach ,  Salih Durak ,  Friedrich W. Richter ,  Wei Liu ,  Sandeep Dutta

    发明人： Joerg Rosenberg ,  Gerd H. Woehrle ,  Thomas Y. Kessler ,  Joerg Breitenbach ,  Salih Durak ,  Friedrich W. Richter ,  Wei Liu ,  Sandeep Dutta

    IPC分类号： A61K9/00 ,  A61K31/485 ,  A61P29/00 ,  A61P25/04

    CPC分类号： A61K9/28 ,  A61K9/0053 ,  A61K9/209 ,  A61K31/167 ,  A61K31/192 ,  A61K31/485 ,  A61K2300/00

    摘要： The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

    摘要翻译： 本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。 这些制剂减少了滥用的可能性。 在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。 本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。

    Apparatus of projector headlights
    7.
    发明授权
    Apparatus of projector headlights 有权

    公开(公告)号：US11686448B1

    公开(公告)日：2023-06-27

    申请号：US17699103

    申请日：2022-03-19

    申请人： Wei Liu

    发明人： Wei Liu

    IPC分类号： B60Q1/00 ,  F21S41/683 ,  F21S41/32 ,  F21S41/43 ,  F21S41/25 ,  F21W102/135

    CPC分类号： F21S41/683 ,  F21S41/25 ,  F21S41/32 ,  F21S41/43 ,  F21W2102/135

    摘要： This invention is a projector headlight that, while offering dual beam patterns, boasts a 100% utilization of the light emitted from a light source by one of the following methods: (1) employing a reflective cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern, (2) using reversible cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern with no moving part involved, (3) utilizing a selective light-filter cutoff means to selectively reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern without making use of any moving part, (4) using a low-beam light-emitting subassembly and a high-beam light-emitting subassembly that are separated by partition means to achieve dual beam patterns with no moving part, or (5) adopting a low-beam light-emitting subassembly in low-beam pattern and a high-beam light-emitting subassembly in high-beam pattern without any moving part.