公开(公告)号：US6147396A

公开(公告)日：2000-11-14

申请号：US250363

申请日：1999-02-12

申请人： Wolfgang Troger ,  Alfons Graf

发明人： Wolfgang Troger ,  Alfons Graf

IPC分类号： H01H37/74 ,  H01L23/495 ,  H01L23/62

CPC分类号： H01L23/62 ,  H01H37/74 ,  H01L23/495 ,  H01L23/49562 ,  H01L24/49 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/49171 ,  H01L24/48 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01012 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/0106 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/181 ,  H01L2924/19043

摘要： A power semiconductor module includes a lead frame, at least one power semiconductor component fastened on said lead frame, a housing at least partly encapsulating said power semiconductor component, a plurality of output lines electrically conductively connected to said power semiconductor component and including load current-carrying output lines, electrically conductive connections between said at least one power semiconductor component and at least said load current-carrying output lines, and an interrupter. The interrupter irreversibly interrupts at least said load current-carrying output lines and/or said electrically conductive connections and at least said load current-carrying output lines, if the temperature of said power semiconductor component exceeds a predetermined temperature threshold. The interrupter is formed of a material having a volume-expanding and/or an oxidizing and/or an explosive characteristic with an increasing temperature.

摘要翻译： 功率半导体模块包括引线框架，固定在所述引线框架上的至少一个功率半导体部件，至少部分地封装所述功率半导体部件的壳体，与所述功率半导体部件电连接的多个输出线， 承载输出线，所述至少一个功率半导体部件和至少所述负载输出输出线之间的导电连接以及断续器。 如果所述功率半导体部件的温度超过预定的温度阈值，则所述断路器至少不可逆地中断至少所述负载通电输出线路和/或所述导电连接以及至少所述负载通电输出线路。 断路器由具有随温度升高的体积膨胀和/或氧化和/或爆炸特性的材料形成。

公开(公告)号：US4968794A

公开(公告)日：1990-11-06

申请号：US252725

申请日：1988-10-03

申请人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge C. Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

发明人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge C. Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

IPC分类号： A61K31/55 ,  A61K31/5517 ,  A61P7/02 ,  A61P9/02 ,  A61P11/08 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07C235/40 ,  C07D243/00 ,  C07D249/08 ,  C07D333/00 ,  C07D333/36 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14

CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D495/14

摘要： The invention relates to new thieno-traizolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

摘要翻译： 本发明涉及式I的新的噻吩并[1,3-diazepino-2-carboxylic acid amides]（Ⅰ），其中R1代表氢，C1-C4直链或支链烷基，其可以任选地被 卤素，优选Cl或Br，或羟基，环丙基，C 1 -C 3烷氧基，优选甲氧基或卤素，优选氯或溴; R2和R3各自独立地代表氢，C1-C4直链或支链烷基，C1-C4羟基烷基或两个R2和R3与氮原子一起表示5-，6-或7-元环，其中 任选地含有氮，氧或硫原子作为另外的杂原子，第二氮原子任选被C 1 -C 4烷基，优选甲基取代; R4表示α-吡啶基或苯基，其中苯环优选在2-位上被甲基，卤素，优选氯或溴，硝基或三氟甲基取代; n表示数字0,1,2,3,4,5,6,7或8中的一个; 及其新型中间体。 式I化合物可用于治疗涉及血小板活化因子的病理状况和疾病。

公开(公告)号：US4891378A

公开(公告)日：1990-01-02

申请号：US365169

申请日：1989-06-12

申请人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Dieter Hinzen ,  Franz J. Kuhn ,  Erich Lehr ,  Helmut Ensinger ,  Wolfgang Troger

发明人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Dieter Hinzen ,  Franz J. Kuhn ,  Erich Lehr ,  Helmut Ensinger ,  Wolfgang Troger

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P25/00 ,  A61P25/28 ,  C07D207/26 ,  C07D401/12 ,  C07D413/12 ,  C07D451/02 ,  C07D487/08

CPC分类号： C07D207/26 ,  C07D401/12 ,  C07D413/12 ,  C07D451/02

摘要： The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;R.sub.2 represents hydrogen or a straight-chained or branched alkyl group with 1-4 carbon atoms;R.sub.3 represents a straight-chained or branched alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group which can be mono- or di-substituted by chlorine, bromine, methyl or methoxy, a cyclohexyl group or a dialkylamino alkyl group, where in each alkyl group can contain from 1-3 carbon atoms;R.sub.4 represents hydrogen or a straight-chained or branched alkyl group with 1-3 carbon atoms; orR.sub.3 and R.sub.4 together with the nitrogen atom represent a piperidine, morpholine or piperazine ring, while the ring may be substituted by 1 or 2 methyl groups and the piperazine ring at the nitrogen atom in 4-position may also carry a phenyl, chlorophenyl or benzyl group, or they may represent the nortropanyl group, processes for preparing them and pharmaceutical compositions.The new compounds have proved effective in animal trials in alleviating or remedying conditions or restricted cerebral performance.

公开(公告)号：US4857528A

公开(公告)日：1989-08-15

申请号：US183819

申请日：1988-04-20

申请人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Dieter Hinzen ,  Franz J. Kuhn ,  Erich Lehr ,  Helmut Ensinger ,  Wolfgang Troger

发明人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Dieter Hinzen ,  Franz J. Kuhn ,  Erich Lehr ,  Helmut Ensinger ,  Wolfgang Troger

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P25/00 ,  A61P25/28 ,  C07D207/26 ,  C07D401/12 ,  C07D413/12 ,  C07D451/02 ,  C07D487/08

CPC分类号： C07D207/26 ,  C07D401/12 ,  C07D413/12 ,  C07D451/02

摘要： The invention relates to substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;R.sub.2 represents hydrogen or a straight-chained or branched alkyl group with 1-4 carbon atoms;R.sub.3 represents a straight-chained or branched alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group which can be mono- or di-substituted by chlorine, bromine, methyl or methoxy, a cyclohexyl group or a dialkylamino alkyl group, where in each alkyl group can contain from 1-3 carbon atoms;R.sub.4 represents hydrogen or a straight-chained or branched alkyl group with 1-3 carbon atoms; orR.sub.3 and R.sub.4 together with the nitrogen atom represent a piperidine, morpholine or piperazine ring, while the ring may be substituted by 1 or 2 methyl groups and the piperazine ring at the nitrogen atom in 4-position may also carry a phenyl, chlorophenyl or benzyl group, or they may represent the nortropanyl group, processes for preparing them and pharmaceutical compositions.The new compounds have proved effective in animal trials in alleviating or remedying conditions or restricted cerebral performance.

摘要翻译： 本发明涉及通式为（1）的取代吡咯烷酮，其中R 1表示可被甲基，甲氧基，氟，氯，溴或三氟甲基或吡啶基单取代或二取代的苯基; R 2表示氢或具有1-4个碳原子的直链或支链烷基; R3表示具有1-3个碳原子的直链或支链烷基，具有2-3个碳原子的羟烷基，可被氯，溴，甲基或甲氧基单取代或二取代的苯基，环己基 基团或二烷基氨基烷基，其中在每个烷基中可以含有1-3个碳原子; R4表示氢或具有1-3个碳原子的直链或支链烷基; 或者R3和R4与氮原子一起代表哌啶，吗啉或哌嗪环，而环可以被1或2个甲基取代，4-位氮原子上的哌嗪环也可以带有苯基，氯苯基或 或它们可以代表异丙基丙基，其制备方法和药物组合物。 新化合物已被证明在动物试验中有效减轻或补救病症或限制脑部表现。

公开(公告)号：US4753746A

公开(公告)日：1988-06-28

申请号：US943762

申请日：1986-12-19

申请人： Otto Mesmer ,  Wolfgang Polligkeit ,  Ernst-Uwe Schiffer ,  Wolfgang Troger ,  Andreas Wolter

发明人： Otto Mesmer ,  Wolfgang Polligkeit ,  Ernst-Uwe Schiffer ,  Wolfgang Troger ,  Andreas Wolter

IPC分类号： C11D3/00 ,  C11D3/37 ,  C11D17/04 ,  C08G12/12 ,  C08J9/40 ,  C09K3/22

CPC分类号： C11D3/3703 ,  C11D17/049 ,  C11D3/0031

摘要： The invention is directed to a detergent and a method of producing the same. The detergent is for textile surfaces and especially for textile floor coverings. The detergent includes a pulverized, porous carrier including a foamed, plastified urea-formaldehyde resin foam. The carrier material is enriched with detergent so that the finished product with respect to the carrier material has a weight per unit volume of 60 kg/m.sup.3 and an apparent density of 50 to 150 grams/liter; the granular size of the carrier material is between 0.01 and 12 mm; the surfactant containing water, which adheres to the carrier material, is stored in the carrier material in a completely homogeneous manner in a share of maximally 80% by weight referred to the weight of the carrier material; and, the detergent is produced from the mixture of the carrier material with a highly concentrated aqueous cleaning solution. The method includes the steps of foaming the plastified urea-formaldehyde resin foam; and, combining the free formaledhyde present during the manufacturing process prior to and/or during the foaming of the plastified urea-formaldehyde resin foam by adding formaldehyde binding substances and stabilizing substances to at least one of the solutions selected from the group consisting of the foaming agent solution and the resin solution.

摘要翻译： 本发明涉及一种洗涤剂及其制造方法。 洗涤剂用于织物表面，特别是用于纺织品地板覆盖物。 洗涤剂包括粉碎的多孔载体，其包括发泡的，塑化的脲 - 甲醛树脂泡沫。 载体材料富含洗涤剂，使成品相对于载体材料的每单位体积的重量为60kg / m 3，表观密度为50至150克/升; 载体材料的粒度为0.01〜12mm; 附着在载体材料上的含有表面活性剂的水以完全均匀的方式储存在载体材料中，最大量为载体材料重量的80％（重量）; 并且洗涤剂由载体材料与高度浓缩的水性清洗溶液的混合物制成。 该方法包括使增塑的脲醛树脂发泡体发泡的步骤; 并且通过向至少一种选自以下的溶液中加入甲醛结合物质和稳定物质，在塑化的脲 - 甲醛树脂泡沫的发泡之前和/或期间，在制造过程中存在的游离醛缩合物， 试剂溶液和树脂溶液。

公开(公告)号：US5155103A

公开(公告)日：1992-10-13

申请号：US774683

申请日：1991-10-11

申请人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge Casals-Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

发明人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge Casals-Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

IPC分类号： A61K31/55 ,  A61K31/5517 ,  A61P7/02 ,  A61P9/02 ,  A61P11/08 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07C235/40 ,  C07D243/00 ,  C07D249/08 ,  C07D333/00 ,  C07D333/36 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14

CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D495/14

摘要： The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

摘要翻译： 本发明涉及式I的新的噻吩并三唑并-1,4-二氮杂-2-羧酸酰胺其中R 1表示氢，可以任意被C 1 -C 4直链或支链烷基取代的C 1 -C 4直链或支链烷基 卤素，优选Cl或Br，或羟基，环丙基，C 1 -C 3烷氧基，优选甲氧基或卤素，优选氯或溴; R2和R3各自独立地代表氢，C1-C4直链或支链烷基，C1-C4羟基烷基或两个R2和R3与氮原子一起表示5-，6-或7-元环，其中 任选地含有氮，氧或硫原子作为另外的杂原子，第二氮原子任选被C 1 -C 4烷基，优选甲基取代; R4表示α-吡啶基或苯基，其中苯环优选在2-位上被甲基，卤素，优选氯或溴，硝基或三氟甲基取代; n表示数字0,1,2,3,4,5,6,7或8中的一个; 及其新型中间体。 式I化合物可用于治疗涉及血小板活化因子的病理状况和疾病。

公开(公告)号：US4941599A

公开(公告)日：1990-07-17

申请号：US284998

申请日：1988-12-15

申请人： Ulrich Reinertz ,  Wolfgang Troger ,  Jurgen Wockel

发明人： Ulrich Reinertz ,  Wolfgang Troger ,  Jurgen Wockel

IPC分类号： B65D83/14 ,  B05B7/04 ,  B05B9/04 ,  B05B11/06 ,  B65D83/36

CPC分类号： B05B11/065 ,  B05B11/062

摘要： The invention is directed to an apparatus and a method for thoroughly mixing a suspension containing a fluid and solid matter constituents and spraying the thoroughly mixed suspension onto a surface. The apparatus includes a pressure and seal tight container enclosed on all sides for accommodating the suspension therein. The container has a top region and has a base region whereat the solid matter constituents tend to collect to form a sediment. A cylinder and a piston generate a charge of air under pressure which is conducted through a passage into the base region of the container to break up the sediment and thoroughly mix the solid matter constituents in the fluid as the air under pressure rises through the suspension to collect at the top region of the container where it imparts pressure to the suspension. A nozzle unit mounted on the container vents the container to permit the air under pressure to entrain the thoroughly mixed suspension to form a spray. With the invention, the suspension is always thoroughly mixed for each pumping operation and during the spraying operation so that a loss of function because of blockage of the spray system is prevented.

摘要翻译： 本发明涉及一种充分混合含有流体和固体成分的悬浮液并将彻底混合的悬浮液喷洒到表面上的装置和方法。 该装置包括在所有侧面上封闭的用于容纳悬架的压力和密封容器。 容器具有顶部区域并且具有固体物质成分倾向于收集以形成沉积物的基础区域。 气缸和活塞在压力下产生空气，该空气通过通道进入容器的基部区域，以分解沉淀物并充分混合流体中的固体物质组分，当压力下的空气通过悬浮液升高时 收集在集装箱的顶部区域，并向悬架施加压力。 安装在容器上的喷嘴单元使容器通风，以允许空气在压力下夹带充分混合的悬浮液以形成喷雾。 通过本发明，对于每次抽水操作和在喷涂操作期间，悬浮液总是充分混合，从而防止由于喷雾系统的堵塞而导致的功能丧失。

公开(公告)号：US4561992A

公开(公告)日：1985-12-31

申请号：US461366

申请日：1983-01-27

申请人： Wolfgang Troger ,  Otto Mesmer ,  Renate Friedrichs

发明人： Wolfgang Troger ,  Otto Mesmer ,  Renate Friedrichs

IPC分类号： C11D3/12 ,  C11D3/37 ,  C11D17/00 ,  C11D3/26

CPC分类号： C11D17/0013 ,  C11D17/0043 ,  C11D3/128 ,  C11D3/3703

摘要： An aerosol cleaning agent for textile surfaces, particularly for the cleaning of textile upholstery, contains a plasticized urea-formaldehyde resin foam, a propellant, an antisettling and suspending agent respectively and a liquid. In order to obtain improved cleaning action and improved removability from the article to be cleaned, the aerosol cleaning agent comprises approximately 65 to 75 wt % active substance. This active substance contains sodium-aluminum silicate suspended therein and buffered by acid to a pH of about 7-8--and the plasticized urea-formaldehyde resin foam has open-cell foam particles and is present in particle sizes between the limit values of about 0.005 and 0.120 mm and a density (in dry, non-comminuted condition) of about 50 plus or minus 10 kg/m.sup.3. Therefore it is possible to dispense with the addition of a moisture-retaining cation-active antistatic.

摘要翻译： 用于织物表面的气溶胶清洁剂，特别是用于清洁纺织品内饰物的气溶胶清洁剂分别含有增塑的脲 - 甲醛树脂泡沫，推进剂，抗沉降剂和悬浮剂和液体。 为了获得改进的清洁作用和改进的待清洁制品的可移除性，气溶胶清洁剂包含约65至75重量％的活性物质。 该活性物质含有悬浮于其中的钠 - 硅酸铝，并由酸缓冲至约7-8的pH，而增塑的脲 - 甲醛树脂泡沫具有开孔泡沫颗粒，并且以约0.005的极限值 和0.120mm，密度（干燥，非粉碎状态）为约50加或减10kg / m 3。 因此，可以省去添加保湿阳离子活性抗静电剂。

公开(公告)号：US5082839A

公开(公告)日：1992-01-21

申请号：US539416

申请日：1990-06-15

申请人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge Casals-Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

发明人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge Casals-Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

IPC分类号： A61K31/55 ,  A61K31/5517 ,  A61P7/02 ,  A61P9/02 ,  A61P11/08 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07C235/40 ,  C07D243/00 ,  C07D249/08 ,  C07D333/00 ,  C07D333/36 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14

CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D495/14

摘要： The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1-C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably C1 or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

公开(公告)号：US4762832A

公开(公告)日：1988-08-09

申请号：US943532

申请日：1986-12-18

申请人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Dieter Hinzen ,  Franz J. Kuhn ,  Erich Lehr ,  Helmut Ensinger ,  Wolfgang Troger

发明人： Karl-Heinz Weber ,  Claus Schneider ,  Gerhard Walther ,  Dieter Hinzen ,  Franz J. Kuhn ,  Erich Lehr ,  Helmut Ensinger ,  Wolfgang Troger

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P25/00 ,  A61P25/28 ,  C07D207/26 ,  C07D401/12 ,  C07D413/12 ,  C07D451/02 ,  C07D487/08

CPC分类号： C07D207/26 ,  C07D401/12 ,  C07D413/12 ,  C07D451/02

摘要： The invention relates to new substituted pyrrolidinones of general formula ##STR1## wherein R.sub.1 represents a phenyl group which may be mono- or di-substituted by methyl, methoxy, fluorine, chlorine, bromine or trifluoromethyl, or a pyridyl group;R.sub.2 represents hydrogen or a straight-chained or branched alkyl group with 1-4 carbon atoms;R.sub.3 represents a straight-chained or branched alkyl group with 1-3 carbon atoms, a hydroxyalkyl group with 2-3 carbon atoms, a phenyl group which can be mono- or di-substituted by chlorine, bromine, methyl or methoxy, a cyclohexyl group or a dialkylamino alkyl group, where in each alkyl group can contain from 1-3 carbon atoms;R.sub.4 represents hydrogen or a straight-chained or branched alkyl group with 1-3 carbon atoms; orR.sub.3 and R.sub.4 together with the nitrogen atom represents a piperidine, morpholine or piperazine ring, while the ring may be substituted by 1 or 2 methyl groups and the piperazine ring at the nitrogen atom in 4-position may also carry a phenyl, chlorophenyl or benzyl group, or they may represent the nortropanyl group, processes for preparing them and pharmaceutical compositions.The new compounds have proved effective in animal trails in alleviating or remedying conditions or restricted cerebral performance.

摘要翻译： 本发明涉及通式为（I）的新的取代的吡咯烷酮，其中R 1表示可被甲基，甲氧基，氟，氯，溴或三氟甲基或吡啶基单取代或二取代的苯基; R 2表示氢或具有1-4个碳原子的直链或支链烷基; R3表示具有1-3个碳原子的直链或支链烷基，具有2-3个碳原子的羟烷基，可被氯，溴，甲基或甲氧基单取代或二取代的苯基，环己基 基团或二烷基氨基烷基，其中在每个烷基中可以含有1-3个碳原子; R4表示氢或具有1-3个碳原子的直链或支链烷基; 或R 3和R 4与氮原子一起代表哌啶，吗啉或哌嗪环，而环可以被1或2个甲基取代，4-位氮原子上的哌嗪环也可以带有苯基，氯苯基或 或它们可以代表异丙基丙基，其制备方法和药物组合物。 新化合物已被证明在减轻或补救病症或限制性脑部表现方面在动物踪迹中是有效的。