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    Process for the preparation of 2,4- or 2,6-dihalogeno-aniline
    1.
    发明授权
    Process for the preparation of 2,4- or 2,6-dihalogeno-aniline 失效
    制备2,4-或2,6-二卤代苯胺的方法

    公开(公告)号：US5145958A

    公开(公告)日：1992-09-08

    申请号：US799918

    申请日：1991-11-26

    申请人： Wolfram Kissener ,  Helmut Fiege

    发明人： Wolfram Kissener ,  Helmut Fiege

    IPC分类号： C07C209/68 ,  C07C209/74 ,  C07C211/52

    CPC分类号： C07C209/74

    摘要： 2,4- or 2,6-dihalogeno-aniline can be prepared by reacting an amino-benzoic acid ester of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the meanings indicated in the description, with 2-2.5 moles of a chlorinating or brominating agent in an inert reaction medium at a temperature of 40.degree.-160.degree. C. and subsequently hydrolyzing and decarboxylating the dihalogenated amino-benzoic acid ester.

    摘要翻译： 2,4-或2,6-二卤代苯胺可以通过使式（I）的氨基 - 苯甲酸酯与其中R1，R2和R3具有说明书所示含义的氨基 - 苯甲酸酯与2- 2.5摩尔氯化或溴化剂在惰性反应介质中，在40〜160℃下，随后水解和脱羧二卤代氨基 - 苯甲酸酯。

    Process for the preparation of N,N-diaryl-ureas
    2.
    发明授权
    Process for the preparation of N,N-diaryl-ureas 失效
    制备N，N-二芳基脲的方法

    公开(公告)号：US4820871A

    公开(公告)日：1989-04-11

    申请号：US105856

    申请日：1987-10-07

    申请人： Wolfram Kissener ,  Joachim Franke ,  Helmut Fiege ,  Karlfried Wedemeyer

    发明人： Wolfram Kissener ,  Joachim Franke ,  Helmut Fiege ,  Karlfried Wedemeyer

    IPC分类号： C07C275/28 ,  B01J27/16 ,  C07B61/00 ,  C07C273/18 ,  C07C127/19

    CPC分类号： C07C273/1827

    摘要： N,N-Diaryl-ureas of the formulaR.sup.1 --NR.sup.2 --CO--NH--R.sup.3whereinR.sup.1 and R.sup.2 denote aryl andR.sup.3 denotes alkyl, aralkyl or aryl, can be prepared by a process in which a diarylamine of the formulaR.sup.1 --NH--R.sup.2is reacted with an isocyanate of the formulaR.sup.3 --NCOwherein R.sup.1, R.sup.2 and R.sup.34 have the above meaning, in the presence of acid compounds and in the presence or absence of an inert solvent and/or diluent at elevated temperature.

    摘要翻译： 式R 1 -R 2 -CO-NH-R 3的N，N-二芳基脲其中R 1和R 2表示芳基，R 3表示烷基，芳烷基或芳基，可以通过其中式R 1 -NH -R2与式R3-NCO的异氰酸酯反应，其中R 1，R 2和R 34具有上述含义，在酸性化合物的存在下和在惰性溶剂和/或稀释剂的存在或不存在下，在升高的温度下反应。

    Process for the preparation of isolated 3,4-diaminobenzenesulphonic acid
    5.
    发明授权
    Process for the preparation of isolated 3,4-diaminobenzenesulphonic acid 有权

    公开(公告)号：US06787666B2

    公开(公告)日：2004-09-07

    申请号：US10663827

    申请日：2003-09-16

    申请人： Günter Rauchschwalbe ,  Herbert Emde ,  Wolfram Kissener

    发明人： Günter Rauchschwalbe ,  Herbert Emde ,  Wolfram Kissener

    IPC分类号： C07C30900

    CPC分类号： C07C303/06 ,  C07C309/45

    摘要： Described herein is a process for the preparation of 3,4-diaminobenzenesulphonic acid, characterized in that 1,2-diaminobenzene is reacted with anhydrous sulphuric acid which optionally comprises SO3 in up to stoichiometric amount, at a temperature in the range from 100 to 160° C. with stirring for a reaction time of from 1 to 20 hours; water or ice is added to the reaction mixture, optionally with cooling, up to a sulphuric acid concentration in the range from 30 to 75% by weight, based on the total mixture; the 3,4-diaminobenzenesulphonic acid precipitated out of the reaction mixture is filtered off, optionally washed with dilute sulphuric acid and worked up.

    Process for separating mixtures of nitrobenzaldehyde isomers
    7.
    发明授权
    Process for separating mixtures of nitrobenzaldehyde isomers 失效
    分离硝基苯甲醛异构体混合物的方法

    公开(公告)号：US5567854A

    公开(公告)日：1996-10-22

    申请号：US532513

    申请日：1995-09-22

    申请人： Wolfram Kissener ,  Herbert Emde ,  Achim Fessenbecker

    发明人： Wolfram Kissener ,  Herbert Emde ,  Achim Fessenbecker

    IPC分类号： C07C201/16 ,  C07C205/44 ,  C07C45/82

    CPC分类号： C07C201/16

    摘要： 2- and 3-Nitrobenzaldehydes suitable for use as intermediates for the preparation of pharmaceuticals are obtained in a simple manner and without risk of uncontrolled decompositions by distilling mixtures of nitrobenzaldehyde isomers at bottom temperatures of at most 200.degree. C. in the presence of monomeric and/or polymeric aromatic amines and/or phenols and/or N- and S-containing phenothiazines.

    摘要翻译： 适用于制备药物的中间体的2-和3-硝基苯甲醛以简单的方式获得，没有不受控制的分解的风险，通过在最多200℃的底部温度下蒸馏硝基苯甲醛异构体的混合物，在单体和/ /或聚合芳族胺和/或酚类和/或含N-和S-的吩噻嗪。

    Process for the preparation of 5-fluoro-2-nitrobenzoic acid
    8.
    发明授权
    Process for the preparation of 5-fluoro-2-nitrobenzoic acid 失效
    5-氟-2-硝基苯甲酸的制备方法

    公开(公告)号：US5756831A

    公开(公告)日：1998-05-26

    申请号：US667833

    申请日：1996-06-20

    申请人： Wolfram Kissener ,  Jurgen Kuprat ,  Herbert Emde ,  Klaus-Christian Paetz

    发明人： Wolfram Kissener ,  Jurgen Kuprat ,  Herbert Emde ,  Klaus-Christian Paetz

    IPC分类号： C07C201/08 ,  C07C201/16 ,  C07C205/58

    CPC分类号： C07C201/08

    摘要： 5-Fluoro-2-nitrobenzoic acid having low contents of 3-fluoro-2-nitro-benzoic acid is prepared in a simple manner by nitrating 3-fluorobenzoic acid in an anhydrous medium using an anhydrous nitrating acid and isolating and purifying 5-fluoro-2nitro-benzoic acid, by taking 7.5 to 15 parts by weight of water, based on 1 part by weight of 3-fluorobenzoic acid used, introducing the reaction mixture reacted to exhaustion into this volume of water taken, filtering off the precipitate formed and washing it with water.

    摘要翻译： 通过使用无水硝酸将氮氟酸在无水介质中硝化3-氟苯甲酸，分离纯化5-氟-2-硝基苯甲酸，得到3-氟-2-硝基 - 苯甲酸含量低的5-氟-2-硝基苯甲酸 -2-硝基 - 苯甲酸，通过使用7.5重量份水，以1重量份所用的3-氟苯甲酸为原料，将反应混合物反应至该体积的水中，滤出形成的沉淀物， 用水冲洗。