公开(公告)号：US09309188B2

公开(公告)日：2016-04-12

申请号：US13577278

申请日：2011-02-01

Applicant: Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

Inventor： Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

IPC: C07B37/04 ,  C07B49/00 ,  C07C1/32 ,  C07C15/44 ,  C07C43/205 ,  C07C253/04 ,  C07C17/263 ,  C07C41/30 ,  C07C67/343 ,  C07C209/68 ,  C07C253/30 ,  C07C1/30 ,  C07C17/26 ,  C07C41/24 ,  C07C209/74

CPC classification number: C07C253/04 ,  C07B37/04 ,  C07B49/00 ,  C07C1/30 ,  C07C1/326 ,  C07C17/26 ,  C07C17/2632 ,  C07C41/24 ,  C07C41/30 ,  C07C67/343 ,  C07C209/68 ,  C07C209/74 ,  C07C253/30 ,  C07C2527/128 ,  C07C2531/22 ,  C07C2603/26 ,  C07C11/02 ,  C07C15/44 ,  C07C43/2055 ,  C07C43/205 ,  C07C69/612 ,  C07C25/24 ,  C07C211/48 ,  C07C255/50

Abstract: What is described is a process for preparing organic compounds of the general formula (I) R—R′  (I) by converting a corresponding compound of the general formula (II) R—X  (II) in which X is fluorine, chlorine, bromine or iodine to an organomagnesium compound of the general formula (III) [M+]n[RmMgXkY1]  (III) wherein compounds of the formula (III) are reacted with a compound of the general formula (IV) characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic amounts of an iron compound, based on the compound of the general formula (II), and optionally in the presence of b) a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II).

Abstract translation: 描述的是通过将相应的通式（II）化合物R-X（II）转化为其中X为氟，氯，氯， 溴或碘与通式（III）的有机镁化合物[M +] n [RmMgXkY1]（III）反应，其中式（III）化合物与通式（IV）的化合物反应，其特征在于： （III）与（IV）的化合物在a）催化量的铁化合物存在下进行，基于通式（II）的化合物，并且任选在b）氮，氧和/ 或基于通式（II）的化合物的催化或化学计量的含磷添加剂。

公开(公告)号：US08304550B2

公开(公告)日：2012-11-06

申请号：US12275316

申请日：2008-11-21

Applicant: Alain Cotte ,  Nikolaus Muller ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

Inventor： Alain Cotte ,  Nikolaus Muller ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

IPC: C07D213/63 ,  C07C209/00 ,  C07C41/01 ,  B01J31/18

CPC classification number: C07C41/16 ,  C07C201/12 ,  C07C213/00 ,  C07C231/12 ,  C07D213/643 ,  C07C217/90 ,  C07C233/25 ,  C07C205/38 ,  C07C43/275 ,  C07C43/263 ,  C07C43/257

Abstract: Described is a process for preparing diaryl ethers of the formula (I) Ar—O—Ar′  (I) In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group,by reacting an aryl of formula (II) or a aryloxy salt of formula (III) Ar—OH  (II) Ar—OR  (III) In which Ar has the same meaning as in formula (I) and R is an alkali metal,with an aryl or heteroaryl bromide of formula (IV) Ar′—Br  (IV) In which Ar′ has the same meaning as in formula (I),characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

Abstract translation: 描述了制备式（I）Ar-O-Ar'（I）的二芳基醚的方法，其中Ar是芳基或取代的芳基，Ar'是芳基，取代的芳基，杂芳基或取代的杂芳基，由 使式（II）的芳基或式（III）的芳氧基盐Ar-OH（II）Ar-OR（III）反应其中Ar具有与式（I）中相同的含义，R是碱金属，与 式（Ⅳ）的芳基或杂芳基溴Ar'-Br（Ⅳ）其中Ar'具有与式（I）中相同的含义，其特征在于该反应在铜（I）盐 和1-取代的咪唑作为催化剂体系。

公开(公告)号：US08022255B2

公开(公告)日：2011-09-20

申请号：US12388779

申请日：2009-02-19

Applicant: Alain Cotte ,  Matthias Gotta ,  Lukas Goossen ,  Felix Rudolphi ,  Christoph Oppel ,  Nuria Rodriguez Garrido

Inventor： Alain Cotte ,  Matthias Gotta ,  Lukas Goossen ,  Felix Rudolphi ,  Christoph Oppel ,  Nuria Rodriguez Garrido

IPC: C07C49/00 ,  A01N35/00

CPC classification number: C07C45/68 ,  C07C221/00 ,  C07C253/30 ,  C07D213/50 ,  C07D307/46 ,  C07D333/22 ,  C07C49/782 ,  C07C49/788 ,  C07C49/76 ,  C07C49/813 ,  C07C49/84 ,  C07C225/22 ,  C07C255/56

Abstract: A process for preparing ketones of the general formula (III) where R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and R1 is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, by reacting alpha-oxo carboxylates of the general formula (I) wherein n and m is a number in the range from 1 to 6, M(m+) is a cation, and R has the meaning indicated for formula (III), with aryl bromides of the general formula (II) R1—Br  (II) where R1 has the meaning indicated for formula (III), in the presence of two transition metals or compounds thereof as catalyst, is described.

Abstract translation: 一种制备通式（III）的酮的方法，其中R是具有6至24个碳原子的任选取代的碳环芳族基团或任选取代的烷基或任选取代的具有5至24个碳原子的杂芳族基团，R 1是 任选取代的碳原子数为6〜24的碳环芳基或具有5〜24个碳原子的任意取代的杂芳基，通式（I）的α-氧代羧酸盐反应，其中n和m为1〜 6，M（m +）为阳离子，R为式（III）所示的含义，通式（II）的芳基溴R1-Br（Ⅱ）其中R1具有式（Ⅲ）所示的含义， 在两种过渡金属或其化合物作为催化剂的存在下进行了描述。

公开(公告)号：US07329779B2

公开(公告)日：2008-02-12

申请号：US11392009

申请日：2006-03-29

Applicant: Björn Schlummer ,  Florian Rampf ,  Paul Naab ,  Guido Giffels ,  Matthias Gotta

Inventor： Björn Schlummer ,  Florian Rampf ,  Paul Naab ,  Guido Giffels ,  Matthias Gotta

IPC: C07C303/00

CPC classification number: C07C303/22 ,  C07C303/00 ,  C07C309/00

Abstract: The present invention relates to a process for preparing optionally substituted arylsulphonic anhydrides of the general formula (I)

Abstract translation: 本发明涉及制备通式（I）的任选取代的芳基磺酸酐的方法，

公开(公告)号：US20120245360A1

公开(公告)日：2012-09-27

申请号：US13281646

申请日：2011-10-26

Applicant: Alain Cotté ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf ,  Xiao-feng Wu

Inventor： Alain Cotté ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf ,  Xiao-feng Wu

IPC: C07C17/32 ,  C07C45/68 ,  C07C253/30 ,  C07D213/26 ,  C07C41/30 ,  C07C67/343

CPC classification number: C07C17/263 ,  C07C41/30 ,  C07C45/68 ,  C07C67/343 ,  C07C253/30 ,  C07D213/74 ,  C07D471/04 ,  C07C25/22 ,  C07C22/08 ,  C07C25/02 ,  C07C25/13 ,  C07C255/50 ,  C07C43/225 ,  C07C69/76 ,  C07C69/92 ,  C07C49/80

Abstract: The present invention relates to a process for the production of trifluoromethylated unsubstituted or substituted aryl or heteroaryl compounds which comprises reacting an unsubstituted or substituted aryl or heteroaryl halide with a trifluoroacetate of formula (I) or (II), wherein R1 is hydrogen or a C1-C5 alkyl group and M an alkali metal or an ammonium ion, in the presence of and an anorganic halogenide salt or a trifluoroacetacid salt as activator compound and a catalytic combination of a copper salt with a monodentate, bidentate or tridentate aromatic or aliphatic amine or pyridine ligand.

Abstract translation: 本发明涉及生产三氟甲基化的未取代或取代的芳基或杂芳基化合物的方法，其包括使未取代或取代的芳基或杂芳基卤化物与式（I）或（II）的三氟乙酸盐反应，其中R 1是氢或C 1 -C 5烷基和M碱金属或铵离子，并且在有机卤化物盐或三氟乙酸盐的存在下作为活化剂化合物和铜盐与单齿，二齿或三齿芳族或脂族胺的催化组合，或 吡啶配体。

公开(公告)号：US08030520B2

公开(公告)日：2011-10-04

申请号：US12407947

申请日：2009-03-20

Applicant: Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldemar Maximilian Czaplik

Inventor： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldemar Maximilian Czaplik

IPC: C07C211/00

CPC classification number: C07C1/326 ,  C07B37/04 ,  C07C2523/745 ,  C07C2523/75

Abstract: This invention relates to a process for preparing functionalized aryl, heteroaryl, cycloalkenyl, or alkenyl compounds, by a transition-metal-catalyzed cross-coupling reaction of a substituted or unsubstituted aryl-X, heteroaryl-X, cycloalkenyl-X or alkenyl-X compound with an alkyl, alkenyl, cycloalkyl or cycloalkenyl halide, where X is a halide, diazonium, tosylate (p-toluenesulphonate), mesylate (methanesulphonate) or triflate (trifluoromethanesulphonate) leaving group.

Abstract translation: 本发明涉及通过取代或未取代的芳基-X，杂芳基-X，环烯基-X或链烯基-X的过渡金属催化交叉偶联反应制备官能化芳基，杂芳基，环烯基或烯基化合物的方法 与烷基，烯基，环烷基或环烯基卤化物的化合物，其中X是卤化物，重氮，甲苯磺酸酯（对甲苯磺酸酯），甲磺酸酯（甲磺酸酯）或三氟甲磺酸酯（三氟甲磺酸酯）离去基团。

公开(公告)号：US20090247764A1

公开(公告)日：2009-10-01

申请号：US12407947

申请日：2009-03-20

Applicant: Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldermar Maximilian Czaplik

Inventor： Mark Sundermeier ,  Matthias Gotta ,  Axel Jacobi von Wangelin ,  Waldermar Maximilian Czaplik

IPC: C07D213/127 ,  C07C2/58

CPC classification number: C07C1/326 ,  C07B37/04 ,  C07C2523/745 ,  C07C2523/75

Abstract: A process for preparing organic compounds of the general formula (I) R—R′  (I), where R is a substituted or unsubstituted aromatic, heteroaromatic, cycloalkenylic or alkenylic radical and R′ is a substituted or unsubstituted alkylic, alkenylic, cycloalkylic or cycloalkenylic radical, by reacting a corresponding compound of the general formula (II) R—X  (II), where X is chlorine, bromine, iodine, diazonium, mesylate (methanesulphonate), tosylate (p-toluenesulphonate) or triflate (trifluorosutphonate) and R is as defined for formula (I), with a corresponding compound of the general formula (III) R′—Y  (III), where Y is chlorine, bromine or iodine and R′ is as defined for formula (I), wherein the reaction is carried out in the presence of a) stoichiometric amounts of elemental magnesium, based on the compound of the general formula (II), and b) catalytic amounts of a transition metal compound, based on the compound of the general formula (II), and, if appropriate, c) in the presence of a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II), is described. It is particularly advantageous that the process of the invention is carried out as a one-pot reaction and the organomagnesium compound (Grignard compound) formed in situ as intermediate is not isolated.

公开(公告)号：US20090221832A1

公开(公告)日：2009-09-03

申请号：US12388779

申请日：2009-02-19

Applicant: Alain Cotte ,  Matthias Gotta ,  Lukas Goossen ,  Felix Rudolphi ,  Christoph Oppel ,  Nuria Rodriguez Garrido

Inventor： Alain Cotte ,  Matthias Gotta ,  Lukas Goossen ,  Felix Rudolphi ,  Christoph Oppel ,  Nuria Rodriguez Garrido

IPC: C07D213/50 ,  C07C45/61 ,  C07D333/22

CPC classification number: C07C45/68 ,  C07C221/00 ,  C07C253/30 ,  C07D213/50 ,  C07D307/46 ,  C07D333/22 ,  C07C49/782 ,  C07C49/788 ,  C07C49/76 ,  C07C49/813 ,  C07C49/84 ,  C07C225/22 ,  C07C255/56

Abstract: A process for preparing ketones of the general formula (III) where R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and R1 is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, by reacting alpha-oxo carboxylates of the general formula (I) whereinn and m is a number in the range from 1 to 6,M(m+) is a cation, andR has the meaning indicated for formula (III),with aryl bromides of the general formula (II) R1—Br   (II) whereR1 has the meaning indicated for formula (III),in the presence of two transition metals or compounds thereof as catalyst, is described.

Abstract translation: 一种制备通式（III）的酮的方法，其中R是具有6至24个碳原子的任选取代的碳环芳族基团或任选取代的烷基或任选取代的具有5至24个碳原子的杂芳族基团，R 1是 任选取代的碳原子数为6〜24的碳环芳基或具有5〜24个碳原子的任意取代的杂芳族基，通式（I）的α-氧代羧酸盐反应，其中n和m为1〜 6，M（m +）为阳离子，R为式（III）所示的含义，通式（II）的芳基溴<？in-line-formula description =“In-Line Formulas”end =“ 引线“→R1-Br（II）<？in-line-formula description =”In-line Formulas“end =”tail“？>其中R1具有式（III）所示的含义， 金属或其化合物作为催化剂。

公开(公告)号：US20090143594A1

公开(公告)日：2009-06-04

申请号：US12275316

申请日：2008-11-21

Applicant: Alain Cotte ,  Nikolaus Muller ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

Inventor： Alain Cotte ,  Nikolaus Muller ,  Matthias Gotta ,  Matthias Beller ,  Thomas Schareina ,  Alexander Zapf

IPC: C07C41/01 ,  C07C209/00 ,  C07D213/63 ,  B01J31/18

CPC classification number: C07C41/16 ,  C07C201/12 ,  C07C213/00 ,  C07C231/12 ,  C07D213/643 ,  C07C217/90 ,  C07C233/25 ,  C07C205/38 ,  C07C43/275 ,  C07C43/263 ,  C07C43/257

Abstract: Described is a process for preparing diaryl ethers of the formula (I) Ar—O—Ar′  (I) In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, by reacting an aryl of formula (II) or a aryloxy salt of formula (III) Ar—OH   (II) Ar—OR   (III) In which Ar has the same meaning as in formula (I) and R is an alkali metal, with an aryl or heteroaryl bromide of formula (IV) Ar′—Br   (IV) In which Ar′ has the same meaning as in formula (I), characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

Abstract translation: 描述了制备式（I）的二芳基醚的方法<？in-line-formula description =“In-line Formulas”end =“lead”→Ar-O-Ar'（I） -formulae description =“In-line Formulas”end =“tail”？>其中Ar是芳基或取代的芳基，Ar'是芳基，取代的芳基，杂芳基或取代的杂芳基，通过使式 II）或式（III）的芳氧基盐<？in-line-formula description =“In-line Formulas”end =“lead”？> Ar-OH（II）<？in-line-formula description =“In “公式”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> Ar-OR（III）<？in-line-formula description =“In 其中Ar具有与式（I）中相同的含义并且R是碱金属，其中式（IV）的芳基或杂芳基溴<？在线配方说明书 =“在线公式”end =“lead”？> Ar'-Br（IV）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Ar' 意义如式（I）所示 其特征在于反应在铜（I）盐和1-取代的咪唑作为催化剂体系的存在下进行。

公开(公告)号：US20130184485A1

公开(公告)日：2013-07-18

申请号：US13577278

申请日：2011-02-01

Applicant: Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

Inventor： Matthias Gotta ,  Bernd Wilhelm Lehnemann ,  Waldemar Maximilian Czaplik ,  Matthias Mayer ,  Axel Jacobi Von Wangelin

IPC: C07C253/04 ,  C07C1/30 ,  C07C17/26 ,  C07C209/74 ,  C07C41/24

CPC classification number: C07C253/04 ,  C07B37/04 ,  C07B49/00 ,  C07C1/30 ,  C07C1/326 ,  C07C17/26 ,  C07C17/2632 ,  C07C41/24 ,  C07C41/30 ,  C07C67/343 ,  C07C209/68 ,  C07C209/74 ,  C07C253/30 ,  C07C2527/128 ,  C07C2531/22 ,  C07C2603/26 ,  C07C11/02 ,  C07C15/44 ,  C07C43/2055 ,  C07C43/205 ,  C07C69/612 ,  C07C25/24 ,  C07C211/48 ,  C07C255/50

Abstract: What is described is a process for preparing organic compounds of the general formula (I) R—R′  (I) by converting a corresponding compound of the general formula (II) R—X   (II) in which X is fluorine, chlorine, bromine or iodine to an organomagnesium compound of the general formula (III) [M+]n[RmMgXkY1]  (III) wherein compounds of the formula (III) are reacted with a compound of the general formula (IV) characterized in that the reaction of (III) with (IV) is performed in the presence of a) catalytic amounts of an iron compound, based on the compound of the general formula (II), and optionally in the presence of b) a nitrogen-, oxygen- and/or phosphorus-containing additive in a catalytic or stoichiometric amount, based on the compound of the general formula (II).

Abstract translation: 描述的是通过将相应的通式（II）RX（II）的化合物（其中X是氟，氯，溴或溴）或其盐，其中R 1，R 2， 碘与通式（III）的化合物（III）反应的通式（III）的有机镁化合物[M +] n [RmMgXkY1]（III）其中式（III）化合物与通式（IV）的化合物反应，其特征在于（III ）与（IV）化合物在（a）催化量的铁化合物（基于通式（II）的化合物）存在下进行，任选在b）氮，氧和/或磷 基于通式（II）的化合物，催化剂或化学计量的添加剂。