公开(公告)号：US20160303283A1

公开(公告)日：2016-10-20

申请号：US15099957

申请日：2016-04-15

Applicant: Worcester Polytechnic Institute

Inventor： Keith A. Gagnon ,  Thomas J. Moutinho, JR. ,  Kevin A. Reyer ,  Alyssa L. Bornstein ,  Megan O'Brien ,  George D. Pins ,  Glenn R. Gaudette

IPC: A61L27/22 ,  A61L27/54 ,  A61L27/38 ,  A61L27/52 ,  B29C33/38 ,  G03F7/32 ,  B29C41/00 ,  B29C41/42 ,  B29C65/00 ,  B29C41/20 ,  G03F7/20 ,  G03F7/38 ,  A61K35/34 ,  B29C33/40

CPC classification number: A61L27/225 ,  A61K35/34 ,  A61L27/3826 ,  A61L27/52 ,  A61L27/54 ,  B29C33/3842 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/405 ,  B29C33/424 ,  B29C41/003 ,  B29C41/20 ,  B29C41/42 ,  B29C65/002 ,  B29K2089/00 ,  B29K2883/00 ,  B29L2031/753 ,  C12N2533/56 ,  G03F7/0002 ,  G03F7/2002 ,  G03F7/32 ,  G03F7/38

Abstract: A scaffold, a method of using the scaffold and a method of preparing the scaffold which may promote the growth or survival of cells and tissues. The scaffold comprises at least one microvascular layer formed from a thin-film fibrin, the microvascular layer configured to sustain and promote growth of cells and having one or more microfluidics channels embedded in the microvascular layer, the channels configured to contain nutrients needed for growth of the cells, and the channels configured to permit diffusion of the nutrients from the channels to the cells.

Abstract translation: 支架，使用支架的方法和制备可促进细胞和组织的生长或存活的支架的方法。 所述支架包括由薄膜纤维蛋白形成的至少一个微血管层，所述微血管层被配置为维持和促进细胞的生长并且具有嵌入在所述微血管层中的一个或多个微流体通道，所述通道被配置成含有生长所需的营养物质 细胞和被配置成允许营养物从通道扩散到细胞的通道。