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公开(公告)号：US10731145B2
公开(公告)日：2020-08-04
申请号：US15380374
申请日：2016-12-15
Applicant: Worcester Polytechnic Institute
Inventor： Amy Peterson , Marsha Rolle , Ivan Ding
Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
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公开(公告)号：US11485964B2
公开(公告)日：2022-11-01
申请号：US16931967
申请日：2020-07-17
Applicant: Worcester Polytechnic Institute
Inventor： Amy Peterson , Marsha Rolle , Ivan Ding
Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
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Patent Agency Ranking
公开(公告)号：US20200016297A1
公开(公告)日：2020-01-16
申请号：US16585698
申请日：2019-09-27
Applicant: Worcester Polytechnic Institute
Inventor： Marsha Rolle , Fioleda Prifti , Christopher Malcuit , Terri Anne Camesano , Tanja Dominko , Denis Kole , Destin Heilman
Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.
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公开(公告)号：US20180256070A1
公开(公告)日：2018-09-13
申请号：US15916628
申请日：2018-03-09
Applicant: Worcester Polytechnic Institute
Inventor： Lucy Garvey , Lubna Hassan , Kyla Nichols , Allison Paquin , Robert J. Daniello , Marsha Rolle
CPC classification number: A61B5/0878 , A61B5/0809 , A61B5/085 , A61B5/091 , A61B5/1135 , A61B2503/40 , A61B2562/0271 , A61B2562/029
Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.
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公开(公告)号：US20210171931A1
公开(公告)日：2021-06-10
申请号：US16931967
申请日：2020-07-17
Applicant: Worcester Polytechnic Institute
Inventor： Amy Peterson , Marsha Rolle , Ivan Ding
Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
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公开(公告)号：US20170166884A1
公开(公告)日：2017-06-15
申请号：US15380374
申请日：2016-12-15
Applicant: Worcester Polytechnic Institute
Inventor： Amy Peterson , Marsha Rolle , Ivan Ding
Abstract: Device, and methods of using or making the device, for engineering cells in vitro are disclosed. In some aspects, a cell culture device comprises at least one glass or polymer surface configured for incubating cells in a culture medium; a charged molecule electrostatically bound to the surface; and a polyelectrolyte multilayer (PEM) electrostatically bound to the charged molecule, the PEM comprising one or more bi-layers of oppositely charged polyelectrolytes, and the PEM having a sufficient thickness to permit release of the charged molecule into the culture medium in a controlled released manner.
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公开(公告)号：US20150005739A1
公开(公告)日：2015-01-01
申请号：US14296109
申请日：2014-06-04
Applicant: Worcester Polytechnic Institute
Inventor： Glenn Gaudette , George D. Pins , Marsha Rolle , Jacques P. Guyette , Kevin Cornwall
CPC classification number: A61L31/046 , A61B17/0469 , A61B17/06 , A61B17/06166 , A61B2017/00243 , A61B2017/00893 , A61L27/225 , A61L27/3826 , A61L27/3834 , A61L27/3873 , A61L31/16 , A61L2430/20 , C12N5/0068 , C12N11/02 , C12N2533/56
Abstract: Compositions that include microthreads are provided. The compositions can be fully or partially encased in a sleeve along at least a portion of their length and can include biological cells and, optionally, therapeutic agents. Also provided are methods for using the compositions to repair or ameliorate damaged or defective tissue, including cardiovascular tissue (e.g., the myocardium).
Abstract translation: 提供包括微丝的组合。 组合物可以沿其长度的至少一部分完全或部分地包封在套管中，并且可以包括生物细胞和任选的治疗剂。 还提供了使用组合物来修复或改善包括心血管组织（例如心肌）的损伤或缺陷组织的方法。
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