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1.发明授权Isolated cell comprising a nucleic acid encoding antibody inhibitors of gdf-8 and uses thereof 有权包含编码gdf-8的抗体抑制剂的核酸的分离的细胞及其用途公开(公告)号：US09505831B2
公开(公告)日：2016-11-29
申请号：US14256300
申请日：2014-04-18
申请人： Wyeth LLC , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , C12N5/00 , C07K16/22 , C07K14/475 , A61K39/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20110020330A1
公开(公告)日：2011-01-27
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
IPC分类号： A61K39/395 , C07H21/04 , A61P19/08 , C12N5/07
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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3.发明授权Methods of increasing muscle mass or muscle strength using antibody inhibitors of GDF-8 有权使用GDF-8的抗体抑制剂增加肌肉质量或肌肉力量的方法公开(公告)号：US07731961B1
公开(公告)日：2010-06-08
申请号：US11737419
申请日：2007-04-19
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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4.发明授权Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity 有权编码降低GDF-8活性的抗体的分离的核酸分子公开(公告)号：US08710202B2
公开(公告)日：2014-04-29
申请号：US13346042
申请日：2012-01-09
申请人： Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , A61K39/395
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20120107928A1
公开(公告)日：2012-05-03
申请号：US13346042
申请日：2012-01-09
申请人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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6.发明授权Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8 有权通过针对GDF-8的抗体在有需要的患者中增加小梁骨密度的方法公开(公告)号：US08092798B2
公开(公告)日：2012-01-10
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20150024484A1
公开(公告)日：2015-01-22
申请号：US14256300
申请日：2014-04-18
申请人： Wyeth LLC
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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