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公开(公告)号：US20110020330A1
公开(公告)日：2011-01-27
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
IPC分类号： A61K39/395 , C07H21/04 , A61P19/08 , C12N5/07
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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2.发明授权Methods of increasing muscle mass or muscle strength using antibody inhibitors of GDF-8 有权使用GDF-8的抗体抑制剂增加肌肉质量或肌肉力量的方法公开(公告)号：US07731961B1
公开(公告)日：2010-06-08
申请号：US11737419
申请日：2007-04-19
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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3.发明授权Isolated nucleic acid molecule encoding an antibody that reduces GDF-8 activity 有权编码降低GDF-8活性的抗体的分离的核酸分子公开(公告)号：US08710202B2
公开(公告)日：2014-04-29
申请号：US13346042
申请日：2012-01-09
申请人： Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , A61K39/395
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US20120107928A1
公开(公告)日：2012-05-03
申请号：US13346042
申请日：2012-01-09
申请人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , William J. Dunham , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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5.发明授权Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8 有权通过针对GDF-8的抗体在有需要的患者中增加小梁骨密度的方法公开(公告)号：US08092798B2
公开(公告)日：2012-01-10
申请号：US12785975
申请日：2010-05-24
申请人： Jane Aghajanian , William J. Dunham, legal representative , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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公开(公告)号：US07785587B2
公开(公告)日：2010-08-31
申请号：US10858353
申请日：2004-06-01
申请人： Lisa-Anne Whittemore , Xiangping Li
发明人： Lisa-Anne Whittemore , Xiangping Li
IPC分类号： A61K39/395 , A61K31/00 , A61K38/00
CPC分类号： C07K16/24 , A61K39/39533 , A61K2039/505 , A61K2300/00
摘要： The disclosure provides methods for treating neuromuscular disorders in mammals. The disclosed methods include administering therapeutically effective amounts of a GDF-8 inhibitor and a corticosteroid to a subject susceptible to, or having, a neuromuscular disorder, so as to maintain desirable levels of muscle function.
摘要翻译： 本公开提供了治疗哺乳动物神经肌肉疾病的方法。 所公开的方法包括将治疗有效量的GDF-8抑制剂和皮质类固醇施用于对神经肌肉疾病敏感或具有神经肌肉疾病的受试者，以便保持理想的肌肉功能水平。
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公开(公告)号：US20050014733A1
公开(公告)日：2005-01-20
申请号：US10858353
申请日：2004-06-01
申请人： Lisa-Anne Whittemore , Xiangping Li
发明人： Lisa-Anne Whittemore , Xiangping Li
IPC分类号： A61K39/395 , A61P21/00 , C07K16/24 , A61K31/573
CPC分类号： C07K16/24 , A61K39/39533 , A61K2039/505 , A61K2300/00
摘要： The disclosure provides methods for treating neuromuscular disorders in mammals. The disclosed methods include administering therapeutically effective amounts of a GDF-8 inhibitor and a corticosteroid to a subject susceptible to, or having, a neuromuscular disorder, so as to maintain desirable levels of muscle function.
摘要翻译： 本公开提供了治疗哺乳动物神经肌肉疾病的方法。 所公开的方法包括将治疗有效量的GDF-8抑制剂和皮质类固醇施用于对神经肌肉疾病敏感或具有神经肌肉疾病的受试者，以便保持理想的肌肉功能水平。
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8.发明授权Isolated cell comprising a nucleic acid encoding antibody inhibitors of gdf-8 and uses thereof 有权包含编码gdf-8的抗体抑制剂的核酸的分离的细胞及其用途公开(公告)号：US09505831B2
公开(公告)日：2016-11-29
申请号：US14256300
申请日：2014-04-18
申请人： Wyeth LLC , William J. Dunham
发明人： Jane Aghajanian , Neil M. Wolfman , Denise O'Hara , Monique V. Davies , Geertruida M. Veldman , Kristie Grove Bridges , Lisa-Anne Whittemore , Tejvir S. Khurana , Mary L. Bouxsein
IPC分类号： C07H21/04 , C12N5/00 , C07K16/22 , C07K14/475 , A61K39/00
CPC分类号： C07K16/22 , A01K2217/075 , A61K2039/505 , C07K14/475 , C07K2317/76
摘要： The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
摘要翻译： 本公开提供了针对生长和分化因子-8（GDF-8）的新型抗体，其包括在体外和体内抑制GDF-8活性的抗体片段。 本公开还提供用于诊断，预防或治疗肌肉，骨骼或胰岛素代谢退行性疾病的方法。
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