公开(公告)号：US20250109215A1

公开(公告)日：2025-04-03

申请号：US18587839

申请日：2024-02-26

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  A61K39/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20230086017A1

公开(公告)日：2023-03-23

申请号：US17871829

申请日：2022-07-22

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Sung-Hyung Lee

IPC: C07K16/28

Abstract: Provided herein are trispecific antibodies that include a) a first monomer, b) a second monomer, and c) a light chain. The first monomer includes a first variant Fc domain and a variable heavy domain, the second monomer includes a second variant Fc domain and a first scFv domain and the light chain includes a variable light domain. The variable heavy domain and the variable light domain form an antigen binding domain. The trispecific antibody further includes a second scFv domain on either the first or second monomers.

公开(公告)号：US10428155B2

公开(公告)日：2019-10-01

申请号：US14757809

申请日：2015-12-22

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Sung-Hyung Lee

IPC: C07K16/28

Abstract: The invention provides trispecific antibodies that co-engage CD3, CD8 and a tumor target antigen.

公开(公告)号：US20160355600A1

公开(公告)日：2016-12-08

申请号：US14757809

申请日：2015-12-22

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Sung-Hyung Lee

IPC: C07K16/28

CPC classification number: C07K16/2887 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2815 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/626

Abstract: The invention provides trispecific antibodies that co-engage CD3, CD8 and a tumor target antigen.

Abstract translation: 本发明提供与CD3，CD8和肿瘤靶抗原共同结合的三特异性抗体。

公开(公告)号：US12054545B2

公开(公告)日：2024-08-06

申请号：US17542341

申请日：2021-12-03

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Rumana Rashid ,  Sung-Hyung Lee ,  Paul Foster

IPC: A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2809 ,  A61P35/00 ,  C07K16/2869 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2).

公开(公告)号：US11945880B2

公开(公告)日：2024-04-02

申请号：US17542342

申请日：2021-12-03

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/30 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/468 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/40 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20210102003A1

公开(公告)日：2021-04-08

申请号：US17124371

申请日：2020-12-16

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US10889653B2

公开(公告)日：2021-01-12

申请号：US14952714

申请日：2015-11-25

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/28 ,  C07K16/46 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US10316088B2

公开(公告)日：2019-06-11

申请号：US15636590

申请日：2017-06-28

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Rumana Rashid ,  Sung-Hyung Lee ,  Paul Foster

IPC: C07K16/00 ,  C07K16/28 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2).

公开(公告)号：US20160355608A1

公开(公告)日：2016-12-08

申请号：US15141350

申请日：2016-04-28

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.