公开(公告)号：US11426459B2

公开(公告)日：2022-08-30

申请号：US16756973

申请日：2018-10-10

Applicant: Xiamen University

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Mengya Zhang ,  Limin Zhang ,  Ningshao Xia

IPC: A61K39/145 ,  A61K39/00

Abstract: The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.

公开(公告)号：US20210023198A1

公开(公告)日：2021-01-28

申请号：US16756973

申请日：2018-10-10

Applicant: Xiamen University

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Mengya Zhang ,  Limin Zhang ,  Ningshao Xia

IPC: A61K39/145

Abstract: The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.

公开(公告)号：US10696736B2

公开(公告)日：2020-06-30

申请号：US15732536

申请日：2016-06-02

Applicant: XIAMEN UNIVERSITY

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Guosong Wang ,  Mengya Zhang ,  Ningshao Xia

IPC: A61P31/16 ,  A61K39/42 ,  C12N5/12 ,  C12N15/11 ,  C07K16/10 ,  C07K16/42 ,  C12N15/63 ,  G01N33/569 ,  G01N33/577 ,  A61K39/00

Abstract: Provided are a broad-spectrum monoclonal anti-Flu B antibody, cell strains generating the antibody, and a composition comprising the antibody; also provided are uses of the antibody for diagnosing, preventing and/or treating an infection of the Flu B and/or diseases caused by the infection.