公开(公告)号：US20220009969A1

公开(公告)日：2022-01-13

申请号：US17258109

申请日：2019-07-08

Applicant: Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

Inventor： Zizheng Zheng ,  Wei Zhang ,  Lujing Zhang ,  Yongpeng Sun ,  Li Chen ,  Ningshao Xia

IPC: C07K14/005 ,  C12N7/00 ,  A61K39/155 ,  C12N1/04 ,  A61P31/14

Abstract: Provided are a method for inactivating respiratory syncytial virus (RSV) and stabilizing pre-F protein in RSV and inactivated RSV virus obtained thereby. Also provided are a vaccine comprising the inactivated RSV virus and a use of the vaccine in preventing or treating RSV infection or a disease related thereto.

公开(公告)号：US11213580B2

公开(公告)日：2022-01-04

申请号：US16630673

申请日：2018-07-13

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Ying Gu ,  Shaowei Li ,  Shuo Song ,  Maozhou He ,  Zhihai Li ,  Ningshao Xia

IPC: A61K39/00 ,  A61K39/12 ,  C07K14/005 ,  C07K14/025 ,  C12N7/00 ,  A61P31/20 ,  A61K39/39

Abstract: Provided are a mutated HPV16 L1 protein (or a variant thereof), a sequence encoding the same and a method for preparing the same, as well as a virus-like particle comprising the same. The protein (or variant thereof) and the virus-like particle are capable of inducing neutralizing antibodies against at least two types of HPV (e.g., HPV16 and HPV35, or HPV16, HPV35, and HPV31), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also provided are a use of the above protein and virus-like particle in the manufacture of a pharmaceutical composition or vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：US10940194B2

公开(公告)日：2021-03-09

申请号：US15781035

申请日：2016-12-02

Applicant: Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

Inventor： Shaowei Li ,  Zhihai Li ,  Shuo Song ,  Maozhou He ,  Ying Gu ,  Ningshao Xia

IPC: A61K39/12 ,  C07K14/025 ,  C12N7/00 ,  C12N15/70 ,  A61P31/20 ,  C07K14/005 ,  A61K39/00

Abstract: Provided are a mutated HPV58 L1 protein or a variant thereof, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein or a variant thereof and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types, and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：US10723767B2

公开(公告)日：2020-07-28

申请号：US15575140

申请日：2016-05-20

Applicant: XIAMEN UNIVERSITY ,  Xiamen Innovax Biotech Co., Ltd.

Inventor： Shengxiang Ge ,  Tingdong Li ,  Lianzhi Jia ,  Yijian Li ,  Miaoge Xue ,  Yuanjun Zeng ,  Huirong Pan ,  Jun Zhang ,  Ningshao Xia

IPC: C07K14/005 ,  C12N7/00 ,  A61K39/12 ,  A61K39/15 ,  A61P31/14 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00 ,  A61K39/00

Abstract: The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

公开(公告)号：US10696736B2

公开(公告)日：2020-06-30

申请号：US15732536

申请日：2016-06-02

Applicant: XIAMEN UNIVERSITY

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Guosong Wang ,  Mengya Zhang ,  Ningshao Xia

IPC: A61P31/16 ,  A61K39/42 ,  C12N5/12 ,  C12N15/11 ,  C07K16/10 ,  C07K16/42 ,  C12N15/63 ,  G01N33/569 ,  G01N33/577 ,  A61K39/00

Abstract: Provided are a broad-spectrum monoclonal anti-Flu B antibody, cell strains generating the antibody, and a composition comprising the antibody; also provided are uses of the antibody for diagnosing, preventing and/or treating an infection of the Flu B and/or diseases caused by the infection.

公开(公告)号：US10537629B2

公开(公告)日：2020-01-21

申请号：US15924511

申请日：2018-03-19

Applicant: XIAMEN UNIVERSITY ,  BEIJING WANTAI BIOLOGICAL PHARMACY ENTERPRISE CO., LTD.

Inventor： Jun Zhang ,  Jin Wang ,  Chunyan Yang ,  Ying Gu ,  Shaowei Li ,  Ningshao Xia

IPC: A61K39/12 ,  C07K14/005 ,  C12N7/00

Abstract: The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.

公开(公告)号：US10513541B2

公开(公告)日：2019-12-24

申请号：US15781328

申请日：2016-12-02

Applicant: Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

Inventor： Shaowei Li ,  Daning Wang ,  Xinlin Liu ,  Zhihai Li ,  Jun Zhang ,  Ningshao Xia

IPC: C07K14/025 ,  A61K39/12 ,  C07K14/005 ,  C12P21/02 ,  A61P31/20 ,  A61P35/00 ,  A61K39/00

Abstract: Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：US09862933B2

公开(公告)日：2018-01-09

申请号：US14429586

申请日：2013-06-24

Applicant: Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

Inventor： Shengxiang Ge ,  Tingdong Li ,  Qingshun Guo ,  Feihai Xu ,  Jun Zhang ,  Ningshao Xia

IPC: C12N7/04 ,  C12N7/00 ,  A61K38/16 ,  A61K39/00

CPC classification number: C12N7/00 ,  A61K38/162 ,  A61K39/00 ,  C12N7/04 ,  C12N2720/12322 ,  C12N2720/12323 ,  C12N2720/12333 ,  C12N2720/12334 ,  C12N2720/12352

Abstract: The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.

公开(公告)号：US20170014506A1

公开(公告)日：2017-01-19

申请号：US15248779

申请日：2016-08-26

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Shaowei Li ,  Cuiling Song ,  Chunyan Yang ,  Ying Gu ,  Wenxin Luo ,  Ningshao Xia

IPC: A61K39/39 ,  C12N7/00 ,  A61K39/05

CPC classification number: A61K39/39 ,  A61K38/00 ,  A61K39/05 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/34 ,  C07K2319/03 ,  C07K2319/55 ,  C07K2319/74 ,  C12N7/00 ,  C12N9/1048 ,  C12N15/62 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/28122 ,  C12N2770/28134

Abstract: Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.

公开(公告)号：US12097251B2

公开(公告)日：2024-09-24

申请号：US17280805

申请日：2019-09-26

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Shaowei Li ,  Daning Wang ,  Jie Chen ,  Ying Gu ,  Jun Zhang ,  Ningshao Xia

IPC: A61K39/12 ,  A61P31/20 ,  C07K14/015 ,  C12N7/00

CPC classification number: A61K39/12 ,  A61P31/20 ,  C07K14/015 ,  C12N7/00

Abstract: Provided are a mutated HPV51 L1 protein or a variant thereof, a coding sequence thereof, a preparation method therefor, and a virus-like particle containing same, wherein the protein or the variant and the virus-like particle thereof are capable of inducing neutralizing antibodies against at least two types of HPV (for example, HPV51 and HPV69, or HPV51, HPV69 and HPV26). Also provided is the use of the above-mentioned protein and the virus-like particle for preparing a pharmaceutical composition or a vaccine, wherein the pharmaceutical composition or the vaccine can be used to prevent infections of the at least two types of HPV and diseases caused by the infections, such as cervical cancer and condyloma acuminatum.