公开(公告)号：US10696736B2

公开(公告)日：2020-06-30

申请号：US15732536

申请日：2016-06-02

Applicant: XIAMEN UNIVERSITY

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Guosong Wang ,  Mengya Zhang ,  Ningshao Xia

IPC: A61P31/16 ,  A61K39/42 ,  C12N5/12 ,  C12N15/11 ,  C07K16/10 ,  C07K16/42 ,  C12N15/63 ,  G01N33/569 ,  G01N33/577 ,  A61K39/00

Abstract: Provided are a broad-spectrum monoclonal anti-Flu B antibody, cell strains generating the antibody, and a composition comprising the antibody; also provided are uses of the antibody for diagnosing, preventing and/or treating an infection of the Flu B and/or diseases caused by the infection.

公开(公告)号：US11426459B2

公开(公告)日：2022-08-30

申请号：US16756973

申请日：2018-10-10

Applicant: Xiamen University

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Mengya Zhang ,  Limin Zhang ,  Ningshao Xia

IPC: A61K39/145 ,  A61K39/00

Abstract: The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.

公开(公告)号：US20210023198A1

公开(公告)日：2021-01-28

申请号：US16756973

申请日：2018-10-10

Applicant: Xiamen University

Inventor： Yixin Chen ,  Chenguang Shen ,  Junyu Chen ,  Mengya Zhang ,  Limin Zhang ,  Ningshao Xia

IPC: A61K39/145

Abstract: The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.

公开(公告)号：US09650434B2

公开(公告)日：2017-05-16

申请号：US14781391

申请日：2014-04-02

Applicant: Xiamen University

Inventor： Yixin Chen ,  Qingbing Zheng ,  Rui Li ,  Chenguang Shen ,  Shaojun Ke ,  Wenxin Luo ,  Honglin Chen ,  Ningshao Xia

IPC: C07K16/10 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/1018 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2469/10

Abstract: The invention relates to antibodies recognizing epitopes on HA1 domain of hemagglutinin (HA) protein of influenza virus, cell lines for producing the antibodies, and uses thereof. The antibodies according to the invention can specifically bind to HA1 domain of different HA subtypes and specifically bind to HA1 domain of hemagglutinin (HA) protein of H1 subtype (including seasonal H1N1 and 2009 pandemic H1N1) and H5 subtype of influenza viruses. Therefore, the invention also relates to vaccines or pharmaceutical compositions for preventing and/or treating infection of H1 subtype and H5 subtype influenza virus and/or a disease caused by the infection (e.g. influenza), comprising the antibodies according to the invention.