公开(公告)号：US08646110B1

公开(公告)日：2014-02-04

申请号：US13835181

申请日：2013-03-15

Applicant: Xiaoji Xu ,  Gilbert C. Walker

Inventor： Xiaoji Xu ,  Gilbert C. Walker

IPC: G01N13/16 ,  G01N21/35 ,  G01N21/00 ,  G01Q60/24

CPC classification number: G01N21/359 ,  B82Y20/00 ,  G01B9/0203 ,  G01N2201/06113 ,  G01N2201/10 ,  G01Q10/00 ,  G01Q30/02 ,  G01Q60/06 ,  G01Q60/22

Abstract: The present disclosure provides a procedure to obtain the absorption profiles of molecular resonance with ANSOM. The method includes setting a reference field phase to φ=0.5 π relative to the near-field field, and reference amplitude A≧5|αeff|. The requirement on phase precision is found to be

Abstract translation: 本公开提供了获得与ANSOM的分子共振的吸收曲线的程序。 该方法包括将参考场相位设置为相对于近场场的phi =0.5π，参考振幅A> = 5 |αeff|。 相位精度要求为<0.3 pi。 该方法使ANSOM能够以纳米级空间分辨率执行振动光谱。

公开(公告)号：US20140066496A1

公开(公告)日：2014-03-06

申请号：US14110992

申请日：2012-04-11

Applicant: Nikhil A. Gunari ,  Mallika Das ,  Gilbert C. Walker

Inventor： Nikhil A. Gunari ,  Mallika Das ,  Gilbert C. Walker

IPC: A61K31/352

CPC classification number: A61K31/352 ,  A01N43/90 ,  A01N65/00 ,  A01N65/08 ,  A01N65/26 ,  B08B17/02 ,  C09D5/1625 ,  A01N25/02 ,  A01N25/34 ,  A01N27/00

Abstract: There is herein provided a composition comprising azadirachtin, preferably neem oil, and methods of use thereof for inhibiting macrofouling on a polymer in an aquatic environment.

Abstract translation: 本文提供了包含印苦楝子素，优选楝树油的组合物及其用于在水生环境中抑制聚合物上的大颗粒污染的方法。

公开(公告)号：US20130096006A1

公开(公告)日：2013-04-18

申请号：US13642620

申请日：2011-04-20

Applicant: Nikhil A. Gunari ,  Gilbert C. Walker

Inventor： Nikhil A. Gunari ,  Gilbert C. Walker

IPC: C09D153/00

CPC classification number: C09D153/00 ,  C08J3/07 ,  C08J3/09 ,  C08J3/24 ,  C08J2353/00 ,  C09D5/1668

Abstract: The present invention provides a method to transfer block copolymers from water immiscible organic phase to aqueous phase using a phase transfer agent. At higher concentrations, micellar networks of the block copolymers were obtained in the aqueous solution that can be coated onto a variety of substrates. Block copolymer films showed very good antifouling properties. The phase transferred block copolymers can be used to synthesize encapsulated nanoparticle aggregates for biodiagnostic imaging applications. The phase transferred block copolymer micelles can be used to encapsulate active compounds. The invention has applications in drug delivery, crop protection, and medical device coating.

Abstract translation: 本发明提供了使用相转移剂将嵌段共聚物从水不混溶的有机相转移到水相的方法。 在较高浓度下，在可涂覆在各种基材上的水溶液中获得嵌段共聚物的胶束网络。 嵌段共聚物膜显示出非常好的防污性能。 相转移的嵌段共聚物可用于合成用于生物诊断成像应用的包封的纳米颗粒聚集体。 相转移的嵌段共聚物胶束可用于包封活性化合物。 本发明在药物输送，作物保护和医疗器械涂层中具有应用。

公开(公告)号：US20130273561A1

公开(公告)日：2013-10-17

申请号：US13882371

申请日：2011-10-31

Applicant: Gilbert C. Walker ,  Christina M. MacLaughlin ,  Shell IP

Inventor： Gilbert C. Walker ,  Christina M. MacLaughlin ,  Shell IP

IPC: G01N33/53

CPC classification number: G01N33/53 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/54373

Abstract: Phospholipid-microvesicle-encapsulated surface enhanced Raman scattering (SERS) nanoparticles and methods for making the encapsulated particles are described. The encapsulated particles can be used in nanomedicine. Four Raman-active species were used. A bilayer was observed by TEM, and the SERS spectrum of each dye species (SERS reporter) was confirmed.

Abstract translation: 描述了磷脂 - 微囊包封的表面增强拉曼散射（SERS）纳米颗粒和制备包封的颗粒的方法。 包封的颗粒可用于纳米医药。 使用了四种拉曼活性物种。 通过TEM观察双层膜，确认各染料种类（SERS记者）的SERS光谱。

公开(公告)号：US09221994B2

公开(公告)日：2015-12-29

申请号：US13642620

申请日：2011-04-20

Applicant: Nikhil A. Gunari ,  Gilbert C. Walker

Inventor： Nikhil A. Gunari ,  Gilbert C. Walker

IPC: C09D153/00 ,  C08J3/07 ,  C08J3/09 ,  C08J3/24 ,  C09D5/16

CPC classification number: C09D153/00 ,  C08J3/07 ,  C08J3/09 ,  C08J3/24 ,  C08J2353/00 ,  C09D5/1668

Abstract: The present invention provides a method to transfer block copolymers from water immiscible organic phase to aqueous phase using a phase transfer agent. At higher concentrations, micellar networks of the block copolymers were obtained in the aqueous solution that can be coated onto a variety of substrates. Block copolymer films showed very good antifouling properties. The phase transferred block copolymers can be used to synthesize encapsulated nanoparticle aggregates for biodiagnostic imaging applications. The phase transferred block copolymer micelles can be used to encapsulate active compounds. The invention has applications in drug delivery, crop protection, and medical device coating.

Abstract translation: 本发明提供了使用相转移剂将嵌段共聚物从水不混溶的有机相转移到水相的方法。 在较高浓度下，在可涂覆在各种基材上的水溶液中获得嵌段共聚物的胶束网络。 嵌段共聚物膜显示出非常好的防污性能。 相转移的嵌段共聚物可用于合成用于生物诊断成像应用的包封的纳米颗粒聚集体。 相转移的嵌段共聚物胶束可用于包封活性化合物。 本发明在药物输送，作物保护和医疗器械涂层中具有应用。

公开(公告)号：US20110104452A1

公开(公告)日：2011-05-05

申请号：US12764731

申请日：2010-04-21

Applicant: Claudia M. Grozea ,  Gilbert C. Walker

Inventor： Claudia M. Grozea ,  Gilbert C. Walker

IPC: C09D5/16 ,  B05D3/10 ,  B05D3/06 ,  B32B3/10

CPC classification number: C09D5/1637 ,  C09D153/00 ,  Y10T428/24802

Abstract: The present invention provides block copolymer films for application to surfaces exposed to marine environments in order to reduce biofouling of surfaces immersed in the marine environment. The present invention provides a method of fabricating block copolymer films using morphology trapping by lower temperature treatment in conjunction with solvent and or temperature annealing. The present invention inhibits the attachment of marine organisms, but it does not kill the organisms nor is it highly toxic. Cross-linked AB diblock or higher block copolymers, where A and B and any additional blocks if present have different hydrophobicity i.e. A is hydrophobic and B is hydrophilic, mixed with a photo-initiator films that preserve their nanosize domains when immersed in water. The block copolymer films inhibit settlement of marine organisms and can be used as marine antifouling coatings.

Abstract translation: 本发明提供了用于暴露于海洋环境的表面的嵌段共聚物膜，以减少浸入海洋环境中的表面的生物污垢。 本发明提供一种使用低温处理结合溶剂和/或温度退火的形态捕获来制备嵌段共聚物膜的方法。 本发明抑制海洋生物的附着，但不会杀死生物体，也不会剧毒。 交联的AB二嵌段或更高级的嵌段共聚物，其中A和B以及任何另外的嵌段如果存在具有不同的疏水性，即A是疏水性的并且B是亲水的，则与浸渍在水中时保留其纳米尺寸结构域的光引发剂膜混合。 嵌段共聚物膜抑制海洋生物沉降，可用作海洋防污涂料。