专利检索 ap:("Chengyuan Liang" OR "Shunjun Ding" OR "Nan Hui" OR "Juan Li" OR "Dezhu Zhang" OR "Xiaolin Xie") AND inv:"Chengyuan Liang" 第 1 页

1.

发明授权
Gossypol eflornithine Schiff base compound with antitumor activities and a method of preparing the same 有权

公开(公告)号：US10336689B1

公开(公告)日：2019-07-02

申请号：US16359963

申请日：2019-03-20

申请人： Chengyuan Liang , Shunjun Ding , Nan Hui , Juan Li , Dezhu Zhang , Xiaolin Xie

发明人： Chengyuan Liang , Shunjun Ding , Nan Hui , Juan Li , Dezhu Zhang , Xiaolin Xie

IPC分类号： C07C251/24 , A61P35/00 , C07C249/02

摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

2.

发明授权
Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same 有权

公开(公告)号：US10722500B2

公开(公告)日：2020-07-28

申请号：US16270563

申请日：2019-02-07

申请人： Xiaolin Xie , Dezhu Zhang , Shunjun Ding , Chengyuan Liang

发明人： Xiaolin Xie , Dezhu Zhang , Shunjun Ding , Chengyuan Liang

IPC分类号： A61K31/437 , A61P35/00 , G01N33/50

摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

3.

发明授权
Gossypol l-arginine schiff base compound with antitumor activities and a method of preparing the same 有权

公开(公告)号：US09975849B1

公开(公告)日：2018-05-22

申请号：US15798877

申请日：2017-10-31

申请人： Xiaolin Xie , Dezhu Zhang , Chengyuan Liang , Lei Tian , Shunjun Ding , Xingke Ju

发明人： Xiaolin Xie , Dezhu Zhang , Chengyuan Liang , Lei Tian , Shunjun Ding , Xingke Ju

IPC分类号： C07C279/14 , C07C277/08

CPC分类号： C07C279/14 , C07B2200/07 , C07B2200/13 , C07C277/08

摘要： A compound with antitumor activities is represented by formula I: A method of preparing the compound of formula I is also disclosed.

4.

发明授权
Gossypol isocyanate ester compounds with antileukemic activities and a method of preparing the same 有权

公开(公告)号：US10858312B1

公开(公告)日：2020-12-08

申请号：US16939766

申请日：2020-07-27

申请人： Xiaolin Xie , Dezhu Zhang , Zhong Meng , Jianguo Meng , Yu Wang , Shunjun Ding , Chengyuan Liang , Liang Xin , Jingyi Li , Jiayun Zhang , Kangxiong Wu , Juan Xia , Han Li

发明人： Xiaolin Xie , Dezhu Zhang , Zhong Meng , Jianguo Meng , Yu Wang , Shunjun Ding , Chengyuan Liang , Liang Xin , Jingyi Li , Jiayun Zhang , Kangxiong Wu , Juan Xia , Han Li

IPC分类号： C07C271/02 , C07C269/06

摘要： A compound of Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed. R is alkyl, haloalkyl, aryl, or substituted aryl. Preferably, R is —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CF3, —CHF2, —CH2CF3,

5.

发明授权
Gossypol isatin schiff base compounds with antitumor activities and a method of preparing the same 有权

公开(公告)号：US10729675B2

公开(公告)日：2020-08-04

申请号：US16270567

申请日：2019-02-07

申请人： Chengyuan Liang , Xingke Ju , Shunjun Ding , Lei Tian , Yuzhi Liu , Xiaolin Xie , Dezhu Zhang , Wenbo Yao , Dan Yang

发明人： Chengyuan Liang , Xingke Ju , Shunjun Ding , Lei Tian , Yuzhi Liu , Xiaolin Xie , Dezhu Zhang , Wenbo Yao , Dan Yang

IPC分类号： A61K31/404 , A61P35/00 , G01N33/50

摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

6.

发明授权
Edaravone-gossypol derivatives with antitumor activities and a method of preparing the same 有权

公开(公告)号：US09758486B1

公开(公告)日：2017-09-12

申请号：US15489713

申请日：2017-04-17

申请人： Chengyuan Liang , Danni Tian , Minyi Jia , Xiaolin Xie , Dezhu Zhang , Weihui Ju , Shunjun Ding , Xuechuan Wang

发明人： Chengyuan Liang , Danni Tian , Minyi Jia , Xiaolin Xie , Dezhu Zhang , Weihui Ju , Shunjun Ding , Xuechuan Wang

IPC分类号： C07D231/36 , C07D231/22 , C07D231/26

CPC分类号： C07D231/36 , C07D231/22 , C07D231/26

摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.

7.

发明授权
有权

公开(公告)号：US11712457B2

公开(公告)日：2023-08-01

申请号：US17173622

申请日：2021-02-11

申请人： Qianqian Zhao , Jialin Li , Dan Yang , Jingyi Li , Liang Xin , Chunyang Shi , Xiaolin Xie , Dezhu Zhang , Ruina Bian , Xingke Ju , Chengyuan Liang , Yanjun Li , Qiao Zeng

发明人： Qianqian Zhao , Jialin Li , Dan Yang , Jingyi Li , Liang Xin , Chunyang Shi , Xiaolin Xie , Dezhu Zhang , Ruina Bian , Xingke Ju , Chengyuan Liang , Yanjun Li , Qiao Zeng

IPC分类号： A61K36/63 , A61P31/04 , A61K47/44 , A61K31/7034 , A61K31/7048

CPC分类号： A61K36/63 , A61K31/7034 , A61K31/7048 , A61K47/44 , A61P31/04 , A61K2236/15 , A61K2236/333 , A61K2236/35 , A61K2236/37 , A61K2236/51 , A61K2236/53

摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

8.

发明授权
Coumarin-gossypol derivatives with antitumor activities and a method of preparing the same 有权

公开(公告)号：US09758503B1

公开(公告)日：2017-09-12

申请号：US15489711

申请日：2017-04-17

申请人： Chengyuan Liang , Danni Tian , Minyi Jia , Xuechuan Wang , Xiaolin Xie , Dezhu Zhang

发明人： Chengyuan Liang , Danni Tian , Minyi Jia , Xuechuan Wang , Xiaolin Xie , Dezhu Zhang

IPC分类号： C07D311/56

CPC分类号： C07D311/56

摘要： A compound with antitumor activities is represented by formula A or formula B R1, R2, R3, and R4 are independently hydrogen, hydroxyl, alkoxy, halogen, formyl, unsubstituted or substituted alkyl, or unsubstituted or substituted cycloalkyl.

9.

发明授权
Hydroxytyrosol 4-methoxycinnamic acid ester with antibacterial activity and a method of preparing the same 有权

公开(公告)号：US10906863B1

公开(公告)日：2021-02-02

申请号：US16845028

申请日：2020-04-09

申请人： Gennian Mao , Limei Wang , Bin Tian , Xingke Ju , Nan Hui , Juan Li , Guaiping Qiao , Dan Yang , Jingwen Xu , Liang Qi , Wenbo Yao , Han Li , Chengyuan Liang

发明人： Gennian Mao , Limei Wang , Bin Tian , Xingke Ju , Nan Hui , Juan Li , Guaiping Qiao , Dan Yang , Jingwen Xu , Liang Qi , Wenbo Yao , Han Li , Chengyuan Liang

IPC分类号： C07C69/736 , C07C67/08

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

10.

发明授权
Hydroxytyrosol ursodeoxycholic acid ester with antioxidant activity and a method of preparing the same 有权

公开(公告)号：US10738077B1

公开(公告)日：2020-08-11

申请号：US16845038

申请日：2020-04-09

申请人： Wenbo Yao , Guaiping Qiao , Juan Li , Nan Hui , Qiao Zeng , Han Li , Bin Tian , Yongbo Wang , Dan Yang , Jingwen Xu , Liang Qi , Yanjun Li , Chengyuan Liang

发明人： Wenbo Yao , Guaiping Qiao , Juan Li , Nan Hui , Qiao Zeng , Han Li , Bin Tian , Yongbo Wang , Dan Yang , Jingwen Xu , Liang Qi , Yanjun Li , Chengyuan Liang

IPC分类号： C07J9/00 , C07C29/10 , A61K47/28

摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.