摘要:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
摘要:
A general purpose processor architecture (methods and apparatuses) that can discern all subsets of a serial data stream which fulfill an arbitrarily complex reference pattern. The invention comprises an ordered set of Detection Cells conditionally interconnected according to the reference pattern and operationally controlling one another's states through the network. The invention preferably includes a Host Interface to enable reporting of Results from a search session as well as the input and control of reference patterns and source data.
摘要:
The invention provides, for example, in vitro and in vivo methods for screening modulators of NOS-2 activity using p53 mutant cells, methods of predicting the benefit of administering NOS-2 inhibitors to a cancer patient, and methods of treating cancer by administering NOS-2 inhibitors to patients with p53 mutant cancers.
摘要:
A general purpose processor architecture (methods and apparatuses) that can discern all subsets of a serial data stream which fulfill an arbitrarily complex reference pattern. The invention comprises an ordered set of Detection Cells conditionally interconnected according to the reference pattern and operationally controlling one another's states through the network. The invention preferably includes a Host Interface to enable reporting of Results from a search session as well as the input and control of reference patterns and source data.
摘要:
A brush holder assembly for a dynamo-electric machine includes a brush fixture snap-fittingly secured to a shielding fixture. A brush member is moveably mounted within the brush fixture and includes a recessed region, and a shunt member. The shunt member includes a first end operatively connected to the brush member at the recessed region that extends through an intermediate region to a second end. A constant force spring is operatively connected between the second end section of the brush and the brush fixture. The brush holder assembly also includes a shunt retainer mounted in the brush fixture abutting the brush member. The shunt retainer includes a first leg portion, a second leg portion and a base portion. The shunt retainer is configured to maintain proper alignment of the constant force spring and prevent entanglement of the shunt member.
摘要:
A brush holder assembly for a dynamo-electric machine includes a brush fixture snap-fittingly secured to a shielding fixture. A brush member is moveably mounted within the brush fixture and includes a recessed region, and a shunt member. The shunt member includes a first end operatively connected to the brush member at the recessed region that extends through an intermediate region to a second end. A constant force spring is operatively connected between the second end section of the brush and the brush fixture. The brush holder assembly also includes a shunt retainer mounted in the brush fixture abutting the brush member. The shunt retainer includes a first leg portion, a second leg portion and a base portion. The shunt retainer is configured to maintain proper alignment of the constant force spring and prevent entanglement of the shunt member.
摘要:
This invention relates to methods and compositions for the diagnosis of neuroendocrine lung cancers. In particular, the invention concerns the use of cDNA microarrays to facilitate the differential diagnosis of neuroendocrine tumor types.
摘要:
This disclosure provides a novel tumor suppressor, referred to as p28ING5, nucleic acid molecules encoding this protein, and methods of making and using these molecules. Also provided are methods of ameliorating, treating, detecting, prognosing, and diagnosing diseases and conditions associated with abnormal p28ING5 expression, such as neoplasia. Kits are also provided.