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    Modulation of diacylglycerol acyltransferase 2 expression
    2.
    发明授权
    Modulation of diacylglycerol acyltransferase 2 expression 有权
    二酰基甘油酰基转移酶2表达的调控

    公开(公告)号：US08258289B2

    公开(公告)日：2012-09-04

    申请号：US12748281

    申请日：2010-03-26

    申请人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    发明人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    IPC分类号： C07H21/04

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

    摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

    MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 2 EXPRESSION
    3.
    发明申请
    MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 2 EXPRESSION 有权
    二乙酰胆碱酯酶2的表达调控

    公开(公告)号：US20130123331A1

    公开(公告)日：2013-05-16

    申请号：US13566674

    申请日：2012-08-03

    申请人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    发明人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

    摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

    Compositions and their uses directed to diacylglycerol acyltransferase 1
    4.
    发明授权
    Compositions and their uses directed to diacylglycerol acyltransferase 1 有权
    组合物及其用于二酰基甘油酰基转移酶的用途1

    公开(公告)号：US08003620B2

    公开(公告)日：2011-08-23

    申请号：US11834640

    申请日：2007-08-06

    申请人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    发明人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12Y203/0102

    摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.

    摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。

    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1
    6.
    发明申请
    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1 失效
    组合物及其用途指向二乙酰胆碱酯酶1

    公开(公告)号：US20120029050A1

    公开(公告)日：2012-02-02

    申请号：US13177457

    申请日：2011-07-06

    申请人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    发明人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    IPC分类号： A61K31/713 ,  A61P1/16

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12Y203/0102

    摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.

    摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。

    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1
    8.
    发明申请
    COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1 有权
    组合物及其用途指向二乙酰胆碱酯酶1

    公开(公告)号：US20090054359A1

    公开(公告)日：2009-02-26

    申请号：US11834640

    申请日：2007-08-06

    申请人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    发明人： Xing-Xian Yu ,  Sanjay Bhanot ,  Brett P. Monia

    IPC分类号： A61K31/7052 ,  A61P1/16

    CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12Y203/0102

    摘要： Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.

    摘要翻译： 本文公开了用于调节DGAT-1活性的化合物，组合物和方法。 优选地，来自核酸的DGAT-1的表达被抑制。 提供了直接治疗或改善肝纤维化或通过治疗潜在病因的方法。 优选地，治疗，改善或预防包括施用DGAT-1活性调节剂。

    Modulation of diacylglycerol acyltransferase 2 expression
    9.
    发明授权
    Modulation of diacylglycerol acyltransferase 2 expression 有权
    二酰基甘油酰基转移酶2表达的调控

    公开(公告)号：US08883997B2

    公开(公告)日：2014-11-11

    申请号：US13566674

    申请日：2012-08-03

    申请人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    发明人： Sanjay Bhanot ,  Kenneth W. Dobie ,  Xing-Xian Yu ,  Brett P. Monia

    IPC分类号： C07H21/04 ,  C12N15/113 ,  C07H21/02

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14

    摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.

    摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。

    Methods for modulating expression of RBP4
    10.
    发明授权
    Methods for modulating expression of RBP4 有权
    调节RBP4表达的方法

    公开(公告)号：US08541388B2

    公开(公告)日：2013-09-24

    申请号：US12993250

    申请日：2009-05-21

    申请人： Brett P. Monia ,  Xing-Xian Yu ,  Sanjay Bhanot

    发明人： Brett P. Monia ,  Xing-Xian Yu ,  Sanjay Bhanot

    IPC分类号： C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

    摘要： Methods are provided for modulating RBP4 by administering a RBP4-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the modulation of RBP4. The present invention is also directed to methods of decreasing lipid levels in a subject or for preventing or delaying the onset of a rise in lipid levels in a subject, comprising administering to said subject a RBP4-specific inhibitor.

    摘要翻译： 提供了通过施用RBP4特异性调节剂来调节RBP4的方法。 还提供了通过调节RBP4来治疗受试者的心血管和代谢紊乱或延缓或预防其危险因素的方法。 本发明还涉及降低受试者中的脂质水平或用于预防或延迟受试者中脂质水平升高的发生的方法，包括向所述受试者施用RBP4特异性抑制剂。