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公开(公告)号：US08765908B2
公开(公告)日：2014-07-01
申请号：US13571489
申请日：2012-08-10
申请人： Xu Feng , Shunqing Wang
发明人： Xu Feng , Shunqing Wang
CPC分类号： A61K38/1709
摘要： The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.
摘要翻译： 本发明提供治疗组合物及其使用方法，用于通过调节RANK信号通路来改善骨质量，刚度或强度，或预防和治疗骨质流失。 本发明的治疗组合物包含与RANK基序特异性相互作用以调节破骨细胞发生的RYBP肽或其片段。 本发明还提供了一种组合物及其使用方法，其包含能够通过RYBP-RANK相互作用调节RYBP-RANK相互作用或调节RANK信号通路中的效应物的调节剂。
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公开(公告)号：US20080305501A1
公开(公告)日：2008-12-11
申请号：US11997862
申请日：2006-08-02
申请人： Xu Feng , Duorong Xu , Shunqing Wang
发明人： Xu Feng , Duorong Xu , Shunqing Wang
IPC分类号： G01N33/567 , C07K14/705 , C07H21/04
CPC分类号： C07K14/70578
摘要： The present invention provides methods for identifying agents capable of modulating RANK-mediated invention also provides pharmaceutical compositions and methods of using the same for treating osteoporosis or other diseases. The present invention is based on the functional and structural analysis of a novel RANK signaling motif that was found to play a distinct role in activating RANK-mediated intracellular signaling. This motif can be used to screen for RANK modulators. This motif for treating a variety of diseases that are caused by or associated with abnormal RANK expression or activities.
摘要翻译： 本发明提供了鉴定能够调节RANK介导的发明的试剂的方法，还提供了用于治疗骨质疏松症或其它疾病的药物组合物及其使用方法。 本发明基于一种新型RANK信号基因的功能和结构分析，发现其在激活RANK介导的细胞内信号传导中起独特作用。 该主题可用于筛选RANK调节剂。 该主题用于治疗由RANK表达异常或活动异常引起或与之相关的各种疾病。
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公开(公告)号：US20130012445A1
公开(公告)日：2013-01-10
申请号：US13571489
申请日：2012-08-10
申请人： Xu Feng , Shunqing Wang
发明人： Xu Feng , Shunqing Wang
CPC分类号： A61K38/1709
摘要： The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.
摘要翻译： 本发明提供治疗组合物及其使用方法，用于通过调节RANK信号通路来改善骨质量，刚度或强度，或预防和治疗骨质流失。 本发明的治疗组合物包含与RANK基序特异性相互作用以调节破骨细胞发生的RYBP肽或其片段。 本发明还提供了一种组合物及其使用方法，其包含能够通过RYBP-RANK相互作用调节RYBP-RANK相互作用或调节RANK信号通路中的效应物的调节剂。
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公开(公告)号：US20210101440A1
公开(公告)日：2021-04-08
申请号：US17126062
申请日：2020-12-18
申请人： Shunqing Wang
发明人： Shunqing Wang
摘要： An automobile air conditioner blowing adjusting shifting piece buckle structure comprises a shifting piece body, the shifting piece body comprises an upper shell and a lower shell, and the upper shell and the lower shell are of an integrally-formed structure; the upper shell extends downwards to form a connecting piece; the connecting piece is provided with convex lugs, and shaft holes are formed in the convex lugs; the shaft holes are connected with a shaft pin of a shifting fork; positioning grooves are formed in the peripheries of the shaft holes, and the shaft pin is provided with positioning pieces; the positioning pieces are arranged in the positioning grooves; and the upper shell and the lower shell are of the integrally-formed structure. The upper shell and the lower shell are of the integrally-formed structure, the clamping parts are designed to be connected with the automobile air conditioner blades.
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