公开(公告)号：US20080305501A1

公开(公告)日：2008-12-11

申请号：US11997862

申请日：2006-08-02

申请人： Xu Feng ,  Duorong Xu ,  Shunqing Wang

发明人： Xu Feng ,  Duorong Xu ,  Shunqing Wang

IPC分类号： G01N33/567 ,  C07K14/705 ,  C07H21/04

CPC分类号： C07K14/70578

摘要： The present invention provides methods for identifying agents capable of modulating RANK-mediated invention also provides pharmaceutical compositions and methods of using the same for treating osteoporosis or other diseases. The present invention is based on the functional and structural analysis of a novel RANK signaling motif that was found to play a distinct role in activating RANK-mediated intracellular signaling. This motif can be used to screen for RANK modulators. This motif for treating a variety of diseases that are caused by or associated with abnormal RANK expression or activities.

摘要翻译： 本发明提供了鉴定能够调节RANK介导的发明的试剂的方法，还提供了用于治疗骨质疏松症或其它疾病的药物组合物及其使用方法。 本发明基于一种新型RANK信号基因的功能和结构分析，发现其在激活RANK介导的细胞内信号传导中起独特作用。 该主题可用于筛选RANK调节剂。 该主题用于治疗由RANK表达异常或活动异常引起或与之相关的各种疾病。

公开(公告)号：US08765908B2

公开(公告)日：2014-07-01

申请号：US13571489

申请日：2012-08-10

申请人： Xu Feng ,  Shunqing Wang

发明人： Xu Feng ,  Shunqing Wang

IPC分类号： C07K14/51 ,  A61K38/17

CPC分类号： A61K38/1709

摘要： The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.

摘要翻译： 本发明提供治疗组合物及其使用方法，用于通过调节RANK信号通路来改善骨质量，刚度或强度，或预防和治疗骨质流失。 本发明的治疗组合物包含与RANK基序特异性相互作用以调节破骨细胞发生的RYBP肽或其片段。 本发明还提供了一种组合物及其使用方法，其包含能够通过RYBP-RANK相互作用调节RYBP-RANK相互作用或调节RANK信号通路中的效应物的调节剂。

公开(公告)号：US20130012445A1

公开(公告)日：2013-01-10

申请号：US13571489

申请日：2012-08-10

申请人： Xu Feng ,  Shunqing Wang

发明人： Xu Feng ,  Shunqing Wang

IPC分类号： A61K38/17 ,  A61P19/08 ,  A61P19/02 ,  A61P19/10 ,  A61K38/07 ,  A61P29/00

CPC分类号： A61K38/1709

摘要： The present invention provides a therapeutic composition, and method of use thereof, for improving bone mass, rigidity, or strength, or preventing and treating bone loss via modulation of the RANK signaling pathway. The therapeutic composition of the present invention comprises a RYBP peptide, or fragments thereof, that specifically interact with a motif of RANK to regulate osteoclastogenesis. The present invention further provides a composition, and method of use thereof, comprising a modulator that is capable of modulating the RYBP-RANK interaction, or modulating an effector in the RANK signaling pathway through the RYBP-RANK interaction.

摘要翻译： 本发明提供治疗组合物及其使用方法，用于通过调节RANK信号通路来改善骨质量，刚度或强度，或预防和治疗骨质流失。 本发明的治疗组合物包含与RANK基序特异性相互作用以调节破骨细胞发生的RYBP肽或其片段。 本发明还提供了一种组合物及其使用方法，其包含能够通过RYBP-RANK相互作用调节RYBP-RANK相互作用或调节RANK信号通路中的效应物的调节剂。

公开(公告)号：US20140146048A1

公开(公告)日：2014-05-29

申请号：US14088285

申请日：2013-11-22

申请人： Xu Feng ,  Bartholomew Patrick Keogh

发明人： Xu Feng ,  Bartholomew Patrick Keogh

IPC分类号： G06T17/00 ,  A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0263 ,  A61B2576/026 ,  G01R33/5608 ,  G01R33/56341 ,  G01R33/56366 ,  G06T11/206

摘要： A system and method for displaying MRI parameters measured from a tissue sample such a tumor. A computer system receives MRI data and determines a number of parameters including, a normalized cerebral blood volume (nCBV), a contrast transfer rate constant (kTrans) and apparent diffusion coefficient (ADC) calculated from Bo and B1000 MRI images for data points in the MRI data. These parameters are plotted onto a three-dimensional graph of voxels where the data in the MRI are mapped to a normalized radial distance and angle in the plot. The parameters nCBV, kTrans and 1/ADC are mapped to a color of the voxel and to height of a voxel in the +Z and −Z axes of the three dimensional plot.

摘要翻译： 用于显示从诸如肿瘤的组织样本测量的MRI参数的系统和方法。 计算机系统接收MRI数据并确定多个参数，包括：归一化脑血容量（nCBV），对比度传输速率常数（kTrans）和由Bo和B1000 MRI图像计算的表观扩散系数（ADC），用于数据点 MRI数据。 将这些参数绘制在体素的三维图上，其中MRI中的数据被映射到图中的归一化的径向距离和角度。 将参数nCBV，kTrans和1 / ADC映射到三维图的+ Z和-Z轴中的体素的颜色和体素的高度。

公开(公告)号：US20110189186A1

公开(公告)日：2011-08-04

申请号：US13061471

申请日：2009-08-17

申请人： Xu Feng ,  Zhenqi Shi ,  Erin McCoy

发明人： Xu Feng ,  Zhenqi Shi ,  Erin McCoy

IPC分类号： A61K39/395 ,  G01N33/569 ,  A61P35/04 ,  A61P19/08 ,  A61P19/10

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  G01N33/57415 ,  G01N2333/70596 ,  G01N2500/10 ,  G01N2800/56

摘要： Methods of treating, reducing, and/or preventing cancer metastasis to bone using CD68 blocking agents are provided. For example, the methods can be used to reduce breast cancer metastasis to bone. Also provided are methods of treating, reducing, and/or preventing bone resorption in a subject using CD68 blocking agents. For example, the methods can be used to treat osteoporosis.

摘要翻译： 提供了使用CD68封闭剂治疗，减少和/或预防癌转移至骨的方法。 例如，该方法可用于减少乳腺癌转移至骨骼。 还提供了使用CD68封闭剂治疗，减少和/或预防受试者骨吸收的方法。 例如，该方法可用于治疗骨质疏松症。

公开(公告)号：US5972670A

公开(公告)日：1999-10-26

申请号：US005397

申请日：1998-01-09

申请人： Xu Feng ,  Randy M. Berka ,  Jill Angela Wahleithner

发明人： Xu Feng ,  Randy M. Berka ,  Jill Angela Wahleithner

IPC分类号： C12N9/02

CPC分类号： C12N9/0061

摘要： The present invention relates to mutants of a blue multi-copper oxidase, comprising (a) a substitution of one or more amino acid residues with other amino acid residues, (b) an insertion of one or more amino acid residues and/or (c) a deletion of one or more amino acid residues, wherein the substitution, insertion or deletion is carried out at a position which is located no greater than 15 .ANG. from a Type I (T1) copper site. The present invention also relates to nucleic acid constructs comprising a nucleic acid sequence encoding the mutants of the present invention, host cells comprising the construct of the present invention, and methods for producing mutants of the present invention.

摘要翻译： 本发明涉及蓝色多铜氧化酶的突变体，其包含（a）一个或多个氨基酸残基与其它氨基酸残基的取代，（b）插入一个或多个氨基酸残基和/或（c ）一个或多个氨基酸残基的缺失，其中取代，插入或缺失在位于I型（T1）铜位点不超过15 ANGSTROM的位置进行。 本发明还涉及包含编码本发明突变体的核酸序列，包含本发明构建体的宿主细胞和本发明的突变体的制备方法的核酸构建体。

公开(公告)号：US08853367B1

公开(公告)日：2014-10-07

申请号：US11662799

申请日：2005-09-14

申请人： Xu Feng ,  Wei Liu ,  Duorong Xu

发明人： Xu Feng ,  Wei Liu ,  Duorong Xu

IPC分类号： C12P21/08 ,  A61K38/00 ,  C07K1/00 ,  C12P21/04

CPC分类号： G01N33/6872 ,  G01N33/5005

摘要： The present invention provides methods for identifying agents capable of modulating RANK-mediated signaling pathways. The present invention also provides compositions and methods of using the same to treat osteoporosis or other RANK-related diseases. The present invention is based on the functional and structural analysis of three TRAF-binding motifs (PTM)—namely, PTM3, PTM5, and PTM6, each of which has been found to play a distinct role in the activation of RANK-mediated intracellular signaling. These PTMs can be used to screen for RANK modulators. These PTMs also represent potential drug targets for diseases that are associated with abnormal RANK expression or activity.

摘要翻译： 本发明提供了鉴定能够调节RANK介导的信号传导途径的试剂的方法。 本发明还提供了使用它们治疗骨质疏松症或其它RANK相关疾病的组合物和方法。 本发明是基于三种TRAF结合基序（PTM） - 名称，PTM3，PTM5和PTM6的功能和结构分析，已经发现它们在RANK介导的细胞内信号传导中起着不同的作用 。 这些PTM可用于屏蔽RANK调制器。 这些PTM也代表与RANK异常表达或活性相关的疾病的潜在药物靶点。

公开(公告)号：US5770419A

公开(公告)日：1998-06-23

申请号：US706037

申请日：1996-08-30

申请人： Xu Feng ,  Randy M. Berka ,  Jill Angela Wahleithner

发明人： Xu Feng ,  Randy M. Berka ,  Jill Angela Wahleithner

IPC分类号： C12N9/02

CPC分类号： C12N9/0061

摘要： The present invention relates to mutants of a blue multi-copper oxidase, comprising (a) a substitution of one or more amino acid residues with other amino acid residues, (b) an insertion of one or more amino acid residues and/or (c) a deletion of one or more amino acid residues, wherein the substitution, insertion or deletion is carried out at a position which is located no greater than 15 .ANG. from a Type I (T1) copper site. The present invention also relates to nucleic acid constructs comprising a nucleic acid sequence encoding the mutants of the present invention, host cells comprising the construct of the present invention, and methods for producing mutants of the present invention.

摘要翻译： 本发明涉及蓝色多铜氧化酶的突变体，其包含（a）一个或多个氨基酸残基与其它氨基酸残基的取代，（b）插入一个或多个氨基酸残基和/或（c ）一个或多个氨基酸残基的缺失，其中取代，插入或缺失在位于I型（T1）铜位点不超过15 ANGSTROM的位置进行。 本发明还涉及包含编码本发明突变体的核酸序列，包含本发明构建体的宿主细胞和本发明的突变体的制备方法的核酸构建体。

公开(公告)号：US20120268652A1

公开(公告)日：2012-10-25

申请号：US13500921

申请日：2009-10-10

申请人： Debing Liu ,  Zhibo Chen ,  Xaiodong Gu ,  Xu Feng

发明人： Debing Liu ,  Zhibo Chen ,  Xaiodong Gu ,  Xu Feng

IPC分类号： H04N7/01

CPC分类号： G06T7/0002 ,  G06T2207/10016 ,  G06T2207/20004 ,  G06T2207/20021 ,  G06T2207/30168 ,  H04N7/012 ,  H04N19/117 ,  H04N19/14 ,  H04N19/162 ,  H04N19/85

摘要： Blur is one of the most important features related to image quality. Accurately estimating the blur level of an image is a great help to accurately evaluate its quality. A method for calculating blur of video images comprises calculating a horizontal blur value, and determining characteristic parameters of the video images, including at last progressive/interlaced and spatial resolution level. If the video images are progressive, also a vertical blur value is calculated, and combined with the horizontal blur value. The next step is normalizing the horizontal blur value, or the combined horizontal and vertical blur value, according to predefined min and max values, wherein the min and max values are adapted to the spatial resolution level.

摘要翻译： 模糊是与图像质量相关的最重要的功能之一。 准确估计图像的模糊水平是准确评估其质量的极大帮助。 一种用于计算视频图像模糊的方法包括计算水平模糊值，以及确定视频图像的特征参数，包括最后渐进/隔行扫描和空间分辨率级别。 如果视频图像是渐进的，则还计算垂直模糊值，并与水平模糊值组合。 下一步是根据预定义的最小值和最大值归一化水平模糊值或组合的水平和垂直模糊值，其中最小值和最大值适应于空间分辨率水平。