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    Hypertension diagnosis and therapy using pressure sensor
    1.
    发明授权
    Hypertension diagnosis and therapy using pressure sensor 有权
    高血压诊断和治疗使用压力传感器

    公开(公告)号：US08027724B2

    公开(公告)日：2011-09-27

    申请号：US11833435

    申请日：2007-08-03

    申请人： Xuan Wei ,  Cheng Zhang ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    发明人： Xuan Wei ,  Cheng Zhang ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36564 ,  A61B5/0031 ,  A61B5/0215 ,  A61N1/36114 ,  A61N1/36117

    摘要： An example relates to a method for sensing a pulmonary artery pressure (PAP) and providing a sensed PAP signal, detecting an abnormal blood pressure (BP) condition using information from the sensed PAP signal, delivering a pacing energy to a heart, and automatically altering at least one pacing characteristic in response to the detected abnormal BP condition. The detecting an abnormal BP condition can include detecting various forms of hypertension or hypotension. The automatically altering the at least one pacing characteristic can include automatically altering at least one of a pacing rate, a pacing waveform, an atriventricular (AV) delay, an interventricular (VV) delay, a pacing mode, or a pacing site. The method can also include delivering vagal nerve stimulation and automatically altering the vagal nerve stimulation in response to the detected abnormal BP condition. The detecting the abnormal BP condition can also include using a sensed auxiliary physiological parameter.

    摘要翻译： 一个例子涉及一种用于感测肺动脉压（PAP）并提供感测到的PAP信号的方法，使用来自感测到的PAP信号的信息检测异常血压（BP）状况，将起搏能量递送到心脏，并且自动改变 响应于检测到的异常BP状况的至少一个起搏特征。 检测异常BP病症可包括检测各种形式的高血压或低血压。 自动改变至少一个起搏特征可以包括自动改变起搏速率，起搏波形，房室（AV）延迟，心室间（VV）延迟，起搏模式或起搏部位中的至少一个。 该方法还可以包括递送迷走神经刺激并响应于检测到的异常BP状况自动改变迷走神经刺激。 检测异常BP状况还可以包括使用感测的辅助生理参数。

    HYPERTENSION DIAGNOSIS AND THERAPY USING PRESSURE SENSOR
    2.
    发明申请
    HYPERTENSION DIAGNOSIS AND THERAPY USING PRESSURE SENSOR 有权
    使用压力传感器进行高血压诊断和治疗

    公开(公告)号：US20090036940A1

    公开(公告)日：2009-02-05

    申请号：US11833435

    申请日：2007-08-03

    申请人： Xuan Wei ,  Cheng Zhang ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    发明人： Xuan Wei ,  Cheng Zhang ,  Shantha Arcot-Krishnamurthy ,  Dan Li

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36564 ,  A61B5/0031 ,  A61B5/0215 ,  A61N1/36114 ,  A61N1/36117

    摘要： An example relates to a method for sensing a pulmonary artery pressure (PAP) and providing a sensed PAP signal, detecting an abnormal blood pressure (BP) condition using information from the sensed PAP signal, delivering a pacing energy to a heart, and automatically altering at least one pacing characteristic in response to the detected abnormal BP condition. The detecting an abnormal BP condition can include detecting various forms of hypertension or hypotension. The automatically altering the at least one pacing characteristic can include automatically altering at least one of a pacing rate, a pacing waveform, an atriventricular (AV) delay, an interventricular (VV) delay, a pacing mode, or a pacing site. The method can also include delivering vagal nerve stimulation and automatically altering the vagal nerve stimulation in response to the detected abnormal BP condition. The detecting the abnormal BP condition can also include using a sensed auxiliary physiological parameter.

    摘要翻译： 一个例子涉及一种用于感测肺动脉压（PAP）并提供感测到的PAP信号的方法，使用来自感测到的PAP信号的信息检测异常血压（BP）状况，将起搏能量递送到心脏，并且自动改变 响应于检测到的异常BP状况的至少一个起搏特征。 检测异常BP病症可包括检测各种形式的高血压或低血压。 自动改变至少一个起搏特征可以包括自动改变起搏速率，起搏波形，房室（AV）延迟，心室间（VV）延迟，起搏模式或起搏部位中的至少一个。 该方法还可以包括递送迷走神经刺激并响应于检测到的异常BP状况自动改变迷走神经刺激。 检测异常BP状况还可以包括使用感测的辅助生理参数。

    Patient characteristic based adaptive anti-tachy pacing programming
    4.
    发明授权
    Patient characteristic based adaptive anti-tachy pacing programming 有权
    基于患者特征的自适应反向起搏节奏

    公开(公告)号：US07873414B2

    公开(公告)日：2011-01-18

    申请号：US11736286

    申请日：2007-04-17

    申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

    发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3621

    摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

    摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述其他系统和方法。

    PATIENT CHARACTERISTIC BASED ADAPTIVE ANTI-TACHY PACING PROGRAMMING
    5.
    发明申请
    PATIENT CHARACTERISTIC BASED ADAPTIVE ANTI-TACHY PACING PROGRAMMING 有权
    基于特征特征的自适应防篡改编程

    公开(公告)号：US20080262558A1

    公开(公告)日：2008-10-23

    申请号：US11736286

    申请日：2007-04-17

    申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

    发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3621

    摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

    摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述了其他系统和方法。

    Physiological condition determination based on pressure wave produced by an implantable medical device housing
    6.
    发明授权
    Physiological condition determination based on pressure wave produced by an implantable medical device housing 有权

    公开(公告)号：US10722169B2

    公开(公告)日：2020-07-28

    申请号：US13982159

    申请日：2012-01-24

    申请人： Richard T. Stone ,  Xuan Wei

    发明人： Richard T. Stone ,  Xuan Wei

    IPC分类号： A61B5/00 ,  A61B5/20 ,  A61N1/36 ,  A61B8/08 ,  A61B8/12 ,  A61B8/00 ,  A61B5/11 ,  A61B5/0488

    摘要： A physiological state of a patient is detected by at least producing and detecting pressure waves with a free wall of an implantable medical device (IMD) housing. An actuator element may contact the free wall, e.g., a portion of the IMD housing, and cause movement of the free wall that produces a pressure wave within the fluid and tissue of the patient. A detector element contacting the free wall may in turn detect reflected pressure waves received by the free wall. An acoustic module within the IMD may then determine a physiological condition of the patient, e.g., a bladder fullness state, based on the time delay between the transmitted and reflected pressure waves. In some examples in which the IMD also delivers stimulation therapy to the patient, e.g., incontinence therapy, the IMD may also automatically adjust stimulation therapy based on the determined physiological condition.

    CARDIAC FORCE SENSOR AND METHODS OF USE
    7.
    发明申请
    CARDIAC FORCE SENSOR AND METHODS OF USE 有权
    CARDIAC力传感器及其使用方法

    公开(公告)号：US20080114256A1

    公开(公告)日：2008-05-15

    申请号：US11559702

    申请日：2006-11-14

    申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

    发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

    IPC分类号： A61B5/021

    CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

    摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

    摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

    Defibrillation threshold prediction methods and systems
    8.
    发明申请
    Defibrillation threshold prediction methods and systems 有权
    除颤阈值预测方法和系统

    公开(公告)号：US20070043395A1

    公开(公告)日：2007-02-22

    申请号：US11208923

    申请日：2005-08-22

    申请人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

    发明人： Xuan Wei ,  Robert Sweeney ,  Joseph Bocek ,  Scott Meyer ,  Jeffrey Stahmann ,  Yi Zhang

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3943

    摘要： A nondefibrillating and nonfibrillation-inducing energy is delivered at a first internal thoracic location. A first resulting electrical signal is detected at a second internal thoracic location in or near a target region of a heart. A first defibrillation threshold is estimated using the nondefibrillating and nonfibrillation-inducing energy, the first resulting electrical signal, and a target electric field strength. The defibrillation threshold represents an energy that when delivered at the first internal thoracic location creates an electric field strength in the target region of the heart that meets or exceeds the target electric field strength.

    摘要翻译： 在第一内部胸部位置输送非去纤颤和非诱导性能量。 在心脏的目标区域中或附近的第二内部胸部位置检测到第一个产生的电信号。 使用非去纤颤和非原纤维诱发能量，首先得到的电信号和目标电场强度来估计第一除颤阈值。 除颤阈值表示当在第一内部胸部位置递送时在心脏的目标区域中产生满足或超过目标电场强度的电场强度的能量。

    CARDIAC FORCE SENSOR AND METHODS OF USE
    9.
    发明申请
    CARDIAC FORCE SENSOR AND METHODS OF USE 有权
    CARDIAC力传感器及其使用方法

    公开(公告)号：US20110046496A1

    公开(公告)日：2011-02-24

    申请号：US12940172

    申请日：2010-11-05

    申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

    发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

    IPC分类号： A61N1/365 ,  A61B5/02

    CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

    摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

    摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

    Pain free defibrillation threshold estimation
    10.
    发明授权
    Pain free defibrillation threshold estimation 有权
    无痛除颤阈值估计

    公开(公告)号：US07890167B2

    公开(公告)日：2011-02-15

    申请号：US11695711

    申请日：2007-04-03

    申请人： Xuan Wei

    发明人： Xuan Wei

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3943 ,  A61N1/3956

    摘要： A system and method for painlessly calculating an estimated defibrillation threshold, such as by using an implantable medical device and a controller. The estimated defibrillation threshold can be calculated using a delivered first energy to a first thoracic location, an electric field detected at a second thoracic location, and an electric field detected between a third thoracic location and a fourth thoracic location. The estimated defibrillation threshold represents an energy that, when delivered at the first thoracic location, can create an electric field strength in a target region of the heart that meets or exceeds a target electric field strength.

    摘要翻译： 一种用于无痛地计算估计的除颤阈值的系统和方法，例如通过使用可植入医疗装置和控制器。 可以使用向第一胸部位置传送的第一能量，在第二胸部位置检测到的电场以及在第三胸部位置和第四胸部位置之间检测到的电场来计算估计的除颤阈值。 估计的除颤阈值表示当在第一胸部位置递送时能够在达到或超过目标电场强度的心脏的目标区域中产生电场强度的能量。