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公开(公告)号：US20230227915A1
公开(公告)日：2023-07-20
申请号：US17961571
申请日：2022-10-07
申请人： Yabin Lu , Michael Jinyang Lu
发明人： Yabin Lu , Michael Jinyang Lu
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q1/6806
摘要： Disclosed herein is a method which includes extracting genomic deoxyribonucleic acid (DNA) at locations at or near cancer hotspots from a subject, modifying Tier-1 5hmC on the DNA to a modified 5hmC, detecting and identifying the presence or absence of the modified 5hmC, quantifying the detected and identified modified 5hmC; and providing a report comprising a score, wherein the score is indicative of the presence of cancer.
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公开(公告)号：US11827940B2
公开(公告)日：2023-11-28
申请号：US17961571
申请日：2022-10-07
申请人： Yabin Lu , Michael Jinyang Lu
发明人： Yabin Lu , Michael Jinyang Lu
IPC分类号： C12Q1/6886 , C12Q1/6806
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/112 , C12Q2600/156 , C12Q2600/166
摘要： Disclosed herein is a method which includes extracting genomic deoxyribonucleic acid (DNA) at locations at or near cancer hotspots from a subject, modifying Tier-1 5hmC on the DNA to a modified 5hmC, detecting and identifying the presence or absence of the modified 5hmC, quantifying the detected and identified modified 5hmC; and providing a report comprising a score, wherein the score is indicative of the presence of cancer.
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公开(公告)号：US08620590B2
公开(公告)日：2013-12-31
申请号：US12895626
申请日：2010-09-30
申请人： Yabin Lu , Roger Walker
发明人： Yabin Lu , Roger Walker
IPC分类号： G06F7/00
CPC分类号： G01N33/723
摘要： Methods, systems, and apparatus for accurately determining a proportion (ratio) of two analytes is provided, as well as provide a concentration of a first analyte from a determined concentration of a second analyte and from a proportion of the analytes to each other. In one aspect, a surface model (called a “dose surface” herein) relating the concentrations of the two analytes to the proportion can be used to obtain accurate values for one of the variables (e.g. a concentration or the proportion) when the other two variables have previously been obtained. The dose surface can be a three-dimensional surface and be non-linear. The dose surface model can include multiple regression functions. For example, measured responses can be individually converted to concentrations using two dose-response curves, and the concentrations can be input to a dose surface function to obtain the proportion.
摘要翻译： 提供用于精确测定两种分析物的比例（比例）的方法，系统和装置，以及从确定的第二分析物浓度和一部分分析物彼此提供第一分析物的浓度。 在一个方面，可以使用将两种分析物的浓度与比例相关联的表面模型（称为“剂量表面”），以便当其他两个分析物之间的一个变量（例如浓度或比例）获得准确的值 以前已经获得了变量。 剂量表面可以是三维表面并且是非线性的。 剂量表面模型可以包括多个回归函数。 例如，测量的反应可以使用两个剂量 - 反应曲线单独转化为浓度，并且可以将浓度输入到剂量表面函数以获得比例。
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公开(公告)号：US20210355480A1
公开(公告)日：2021-11-18
申请号：US17214839
申请日：2021-03-27
摘要： A method to simultaneously create multiple SNV, INDEL or fusion sequences harbored in a single cell line is provided. The method uses the CRISPR/Cas9 gene editing system to generate large sequence knock-in cell lines in an AAVS1 locus, or other safe harbor sites. Also provided is a method that allows specifically engineered quantitative marker sequences to accurately reflect copy numbers of inserted SNV, INDEL and fusion sequences. These methods allow accurate measurement of ratio or allele frequencies of genetic variants in a cell.
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公开(公告)号：US08260556B2
公开(公告)日：2012-09-04
申请号：US12196132
申请日：2008-08-21
申请人： Robert Likuski , Roger Walker , Yabin Lu
发明人： Robert Likuski , Roger Walker , Yabin Lu
IPC分类号： G01N33/50 , G01N33/481
CPC分类号： G01N33/723 , G01N33/721
摘要： The ratio of analytes is determined directly from the responses of the analytes using a conversion method. Individual analyte responses are obtained by using a selected measuring technique, and these individual responses are used as the independent variables in a conversion method. The dependent variable of conversion method is the desired analyte ratio. The resulting conversion method is then used to directly calculate the desired ratio of analytes as a function of the measured responses. No intermediate conversions, such as using a calibration curve to convert individual measured analyte responses to concentration values, are needed to obtain the desired ratio.
摘要翻译： 分析物的比例直接由使用转化方法的分析物的反应确定。 通过使用选定的测量技术获得单个分析物响应，并且将这些单独的反应用作转化方法中的独立变量。 转化方法的因变量是所需的分析物比例。 然后使用所得的转化方法直接计算作为测量响应的函数的分析物的期望比例。 不需要中间转换，例如使用校正曲线将单个测量的分析物反应转化为浓度值，以获得所需的比例。
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公开(公告)号：US20140278536A1
公开(公告)日：2014-09-18
申请号：US13843827
申请日：2013-03-15
申请人： Dongxiao Zhang , Di Shan , Chen Peng , Yabin Lu
发明人： Dongxiao Zhang , Di Shan , Chen Peng , Yabin Lu
IPC分类号： G06F19/00
CPC分类号： G16H10/60 , G06F19/3418 , G16H10/20
摘要： A computer implemented method and system provides a mobile application development platform (MADP) for dynamically creating a healthcare provider specific customizable composite mobile application (CCMA) and monitoring healthcare elements of a healthcare recipient using the CCMA. The MADP is accessible by a healthcare provider device and a healthcare recipient device via a network. The MADP stores multiple template objects, for example, sub-applications that perform tasks for monitoring the healthcare elements in an application management database (AMD). The MADP acquires a selection of one or more template objects and one or more dynamic content objects defined by a healthcare provider and dynamically creates the CCMA by integrating the selected template objects and dynamic content objects. The MADP stores the CCMA in the AMD. The CCMA facilitates communication between the healthcare provider device and the healthcare recipient device for monitoring the healthcare elements of the healthcare recipient.
摘要翻译： 计算机实现的方法和系统提供移动应用开发平台（MADP），用于动态地创建医疗保健提供者特定的可定制复合移动应用（CCMA），并使用CCMA监视医疗保健接收者的医疗保健元件。 MADP可由医疗保健提供者设备和医疗保健接收者设备通过网络访问。 MADP存储多个模板对象，例如执行用于监视应用程序管理数据库（AMD）中的医疗保健元素的任务的子应用程序。 MADP获取由医疗保健提供者定义的一个或多个模板对象和一个或多个动态内容对象的选择，并通过集成所选择的模板对象和动态内容对象来动态地创建CCMA。 MADP将CCMA存储在AMD中。 CCMA促进医疗保健提供者设备和医疗保健接收者设备之间的通信，用于监视医疗保健接收者的医疗保健元件。
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公开(公告)号：US20120084010A1
公开(公告)日：2012-04-05
申请号：US12895626
申请日：2010-09-30
申请人： Yabin Lu , Roger Walker
发明人： Yabin Lu , Roger Walker
CPC分类号： G01N33/723
摘要： Methods, systems, and apparatus for accurately determining a proportion (ratio) of two analytes is provided, as well as provide a concentration of a first analyte from a determined concentration of a second analyte and from a proportion of the analytes to each other. In one aspect, a surface model (called a “dose surface” herein) relating the concentrations of the two analytes to the proportion can be used to obtain accurate values for one of the variables (e.g. a concentration or the proportion) when the other two variables have previously been obtained. The dose surface can be a three-dimensional surface and be non-linear. The dose surface model can include multiple regression functions. For example, measured responses can be individually converted to concentrations using two dose-response curves, and the concentrations can be input to a dose surface function to obtain the proportion.
摘要翻译： 提供用于精确测定两种分析物的比例（比例）的方法，系统和装置，以及从确定的第二分析物浓度和一部分分析物彼此提供第一分析物的浓度。 在一个方面，可以使用将两种分析物的浓度与比例相关联的表面模型（称为“剂量表面”），以便当其他两个分析物之间的一个变量（例如浓度或比例）获得准确的值 以前已经获得了变量。 剂量表面可以是三维表面并且是非线性的。 剂量表面模型可以包括多个回归函数。 例如，测量的反应可以使用两个剂量 - 反应曲线单独转化为浓度，并且可以将浓度输入到剂量表面函数以获得比例。
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公开(公告)号：US20100049444A1
公开(公告)日：2010-02-25
申请号：US12196132
申请日：2008-08-21
申请人： Robert Likuski , Roger Walker , Yabin Lu
发明人： Robert Likuski , Roger Walker , Yabin Lu
CPC分类号： G01N33/723 , G01N33/721
摘要： The ratio of analytes is determined directly from the responses of the analytes using a conversion method. Individual analyte responses are obtained by using a selected measuring technique, and these individual responses are used as the independent variables in a conversion method. The dependent variable of conversion method is the desired analyte ratio. The resulting conversion method is then used to directly calculate the desired ratio of analytes as a function of the measured responses. No intermediate conversions, such as using a calibration curve to convert individual measured analyte responses to concentration values, are needed to obtain the desired ratio.
摘要翻译： 分析物的比例直接由使用转化方法的分析物的反应确定。 通过使用选定的测量技术获得单个分析物响应，并且将这些单独的反应用作转化方法中的独立变量。 转化方法的因变量是所需的分析物比例。 然后使用所得的转化方法直接计算作为测量响应的函数的分析物的期望比例。 不需要中间转换，例如使用校正曲线将单个测量的分析物反应转化为浓度值，以获得所需的比例。
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