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公开(公告)号：US5258177A
公开(公告)日：1993-11-02
申请号：US804403
申请日：1991-12-10
IPC分类号： A61K39/395 , C07K16/06
CPC分类号： C07K16/065 , A61K39/39516 , Y10S424/804 , Y10S530/831 , Y10S530/861
摘要： A method of preparing an IgA rich preparation comprising exposing a plasma fraction to an amino acid, organic salt or inorganic salt with optional chromatographic treatment yielding a product suitable for use in medical conditions treatable with IgA.
摘要翻译： 一种制备富含IgA的制剂的方法，包括用可选的色谱处理将血浆级分暴露于氨基酸，有机盐或无机盐，产生适合用于可用IgA治疗的医学状况的产物。
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2.发明授权
公开(公告)号：US6162904A
公开(公告)日：2000-12-19
申请号：US421405
申请日：1999-10-21
CPC分类号： C07K16/065 , A61K2039/505
摘要： A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by heat treating for viral inactivation and fractionating an impure gamma globulin solution and then treating the purified gamma globulin with a solvent-detergent for further viral inactivation. In a continuous process disclosed herein, partially purified gamma globulin solids is not recovered as an intermediate product during the disclosed process. In the continuous process, the fractionation to obtain a purified gamma globulin solution is carried out without precipitation of the desired gamma globulin.
摘要翻译： 用于通过热处理用于病毒灭活并分级分离不纯的γ球蛋白溶液，然后用溶剂洗涤剂处理纯化的γ球蛋白以进一步病毒灭活来生产基本上不含污染病毒的静脉内施用的γ球蛋白溶液的方法。 在本文公开的连续方法中，部分纯化的γ球蛋白固体在所公开的方法中不作为中间产物回收。 在连续方法中，获得纯化的γ球蛋白溶液的分级进行而不沉淀所需的γ球蛋白。
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公开(公告)号：US06693173B2
公开(公告)日：2004-02-17
申请号：US09805397
申请日：2001-03-13
IPC分类号： A61K3514
CPC分类号： C07K1/34 , A61M1/0281 , A61M1/3413 , A61M1/3687 , A61M2205/3324
摘要： A method is provided for removing citrate, aluminum, and other multivalent ions and contaminants from proteins by adjusting the pH of a solution containing the protein to a pH from about 7 to about 10, and diafiltering the pH-adjusted solution against aqueous solutions which have a low level of ions.
摘要翻译： 提供一种通过将含有蛋白质的溶液的pH调节至约7至约10的pH来从蛋白质中除去柠檬酸盐，铝和其它多价离子和污染物的方法，并将pH调节的溶液与含有 低水平的离子。
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4.发明授权Method for preparing dual virally inactivated immune globulin for intravenous administration 失效用于静脉内给药的双病毒灭活免疫球蛋白的制备方法公开(公告)号：US06504012B2
公开(公告)日：2003-01-07
申请号：US09861713
申请日：2001-05-22
IPC分类号： A61K3516
CPC分类号： C07K16/065
摘要： A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, in any order, with a solvent-detergent for viral inactivation and a heat treating for viral inactivation. Thereafter, denatured impurities, residual solvent and aggregate generated by the heat treatment are removed from the gamma globulin.
摘要翻译： 通过分级分离不纯的γ球蛋白溶液，然后以任何顺序用溶剂洗涤剂，用于病毒灭活和用于病毒灭活的热处理来生产静脉内施用的γ球蛋白溶液基本上不含污染病毒的方法 。 此后，从γ-球蛋白中除去变性杂质，残留溶剂和通过热处理产生的骨料。
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5.发明授权Method for repairing dual virally inactivated immune globulin for intravenous administration 失效用于修复用于静脉内施用的双重病毒灭活的免疫球蛋白的方法公开(公告)号：US06441144B1
公开(公告)日：2002-08-27
申请号：US09316117
申请日：1999-05-20
IPC分类号： C07K1606
CPC分类号： C07K16/065
摘要： A process for producing an intravenously-administrable gamma globulin solution substantially free of contaminating viruses by fractionating an impure gamma globulin solution and then treating the purified gamma globulin, with a solvent-detergent for viral inactivation and a heat treating for viral inactivation. Thereafter, denatured impurities, residual solvent and aggregate generated by the heat treatment are removed from the gamma globulin.
摘要翻译： 用于通过分级不纯的γ球蛋白溶液然后用用于病毒灭活的溶剂洗涤剂和用于病毒灭活的热处理纯化的γ球蛋白来生产基本上不含污染病毒的静脉内施用的γ球蛋白溶液的方法。 此后，从γ-球蛋白中除去变性杂质，残留溶剂和通过热处理产生的骨料。
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