公开(公告)号：US20190224631A1

公开(公告)日：2019-07-25

申请号：US16329887

申请日：2017-08-31

申请人： GAMBRO LUNDIA AB

发明人： Benjamin MALARD ,  Corine LAMBERT

IPC分类号： B01D71/42 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  A61M1/16 ,  A61M1/34 ,  B01D69/06

CPC分类号： B01D71/42 ,  A61M1/16 ,  A61M1/3413 ,  B01D67/0027 ,  B01D67/0088 ,  B01D67/0093 ,  B01D69/02 ,  B01D69/06 ,  B01D69/08 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2323/38 ,  B01D2323/46 ,  B01D2325/16 ,  B01D2325/18

摘要： The present disclosure relates to improved semipermeable membranes based on acrylonitrile copolymers for use in dialyzers for the extracorporeal treatment of blood in conjunction with hemodialysis, hemofiltration or hemodiafiltration. The present disclosure further relates to methods of producing such membranes.

公开(公告)号：US20190217001A1

公开(公告)日：2019-07-18

申请号：US16360525

申请日：2019-03-21

申请人： Nikkiso Company Limited

发明人： Satoru Kawarabayashi ,  Sumiaki Matsuo

IPC分类号： A61M1/34

CPC分类号： A61M1/3403 ,  A61M1/16 ,  A61M1/3413 ,  A61M1/3431 ,  A61M1/3458 ,  A61M2205/3337 ,  A61M2205/3393

摘要： There is provided a blood purification apparatus with which the efficiency of dialysate purification can be improved and the reduction in the amount of electrolytes contained in dialysate and necessary for treatment can be suppressed. The blood purification apparatus includes a storage device capable of storing a predetermined amount of dialysate that is necessary for blood purification treatment, a dialysate circulation line through which the dialysate is allowed to circulate by introducing the dialysate in the storage device into the dialyzer and draining waste liquid from the dialyzer into the storage device, and the dialysate purification device that purifies the dialysate in the dialysate circulation line. A treatment state in which the dialysate is allowed to be introduced into the dialyzer without flowing through the dialysate purification device and a purification state in which the dialysate is allowed to be purified by the dialysate purification device are taken switchably.

公开(公告)号：US20180333526A1

公开(公告)日：2018-11-22

申请号：US15773668

申请日：2016-11-08

申请人： GAMBRO LUNDIA AB

发明人： Jan Sternby

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/1607 ,  A61M1/16 ,  A61M1/1611 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3609 ,  A61M1/3653 ,  A61M2205/3317 ,  A61M2230/201 ,  A61M2230/65

摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysis fluid circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for determining or receiving a proposed value (Condprop) of a conductivity for the dialysis fluid in the dialysis supply line (8) and to determine a set value (Condset) for the conductivity in the dialysis fluid as a function of the proposed value (Condprop) and as a function of at least one of a second parameter (UF volume/W; WL/W) indicative of a patient fluid overload and a third parameter (gconc) chosen in the group including: a glucose concentration in the patient and a concentration-related parameter of at least glucose in the patient.

公开(公告)号：US20170252701A1

公开(公告)日：2017-09-07

申请号：US15060251

申请日：2016-03-03

申请人： Micromedics Inc.

发明人： Saeid Mordechai Nosrati

IPC分类号： B01D63/08 ,  B01D61/24 ,  A61F2/04 ,  A61M1/34 ,  A61M1/16 ,  A61F2/02

CPC分类号： B01D63/088 ,  A61F2/022 ,  A61M1/1601 ,  A61M1/1621 ,  A61M1/1696 ,  A61M1/1698 ,  A61M1/3413 ,  A61M1/3417 ,  A61M1/3496 ,  A61M2205/0244 ,  B01D61/025 ,  B01D61/243 ,  B01D61/422 ,  B01D61/425 ,  B01D61/48 ,  B01D61/50 ,  B01D63/085 ,  B01D2311/25 ,  B01D2311/2623 ,  B01D2311/2626 ,  B01D2311/2649 ,  B01D2311/2692 ,  B01D2313/18 ,  B01D2313/38 ,  B01D2313/54 ,  B01D2315/16

摘要： A technology that provides various modular biomimetic microfluidic modules emulating varieties of microvasculature in body. These microfluidic-base capillaries and lymphatic Technology modules are constructed as multilayered-microfluidic microchannels of various shapes, and aspect ratios using diverse biocompatible microfluidic polymers. Then, various semipermeable membranes are sandwiched in between these multilayered microfluidic microchannels. These membranes have different chemical, physical characteristics and MWCO values. Consequently, this design will produce much smaller dimension channels similar to human vasculature to achieve biomimetic properties like of human organs and tissues. By interchanging microfluidic-layers or the membranes various diverse modules are designed that act as building blocks for constructing various medical devices, various forms of dialysis devices including albumin and lipid dialysis, water purification, bioreactors, bio-artificial organ support systems. Connecting various modules in diverse combinations, permutations, in parallel and/or in series to ultimately design many unrelated medical devices such as dialysis, bioreactors and organ support devices.

公开(公告)号：US20170203022A1

公开(公告)日：2017-07-20

申请号：US15474849

申请日：2017-03-30

申请人： NXSTAGE MEDICAL, INC.

发明人： Jeffrey H. BURBANK ,  James M. BRUGGER

IPC分类号： A61M1/16 ,  B65B3/28 ,  B65B55/04 ,  F16L55/07 ,  B01D61/14 ,  C02F1/44 ,  B01L3/00 ,  B65B3/30 ,  A61M1/34

CPC分类号： A61M1/1668 ,  A61J1/05 ,  A61J1/1468 ,  A61J1/1475 ,  A61J1/2003 ,  A61M1/14 ,  A61M1/1656 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1674 ,  A61M1/28 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3462 ,  A61M39/1011 ,  A61M39/288 ,  A61M2205/273 ,  B01D61/14 ,  B01D61/142 ,  B01D61/145 ,  B01D63/00 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2300/0681 ,  B01L2300/0864 ,  B65B3/28 ,  B65B3/30 ,  B65B55/04 ,  C02F1/444 ,  C02F2103/026 ,  F16K7/068 ,  F16L55/00 ,  F16L55/07 ,  Y10T137/8593

摘要： A system that fills multiple containers includes a filter with an inlet port and multiple outlet ports. The outlet ports are pre-attached to containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines is connected to a respective container interior. All of the respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. The system can produce batches of multiple sterile containers with sterile medicament in the containers.

公开(公告)号：US09707332B2

公开(公告)日：2017-07-18

申请号：US15301398

申请日：2015-03-31

申请人： Taebeom Cho

发明人： Taebeom Cho

IPC分类号： A61M1/34 ,  A61M1/36 ,  A61M1/16 ,  B01D63/04 ,  B01D61/18 ,  B01D61/24 ,  A61M1/26

CPC分类号： A61M1/3417 ,  A61M1/16 ,  A61M1/1623 ,  A61M1/1696 ,  A61M1/3413 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3679 ,  A61M2205/75 ,  B01D63/04 ,  B01D63/043 ,  B01D2311/2626 ,  B01D2313/08 ,  B01D2313/20 ,  B01D2313/21 ,  B01D2313/40 ,  B01D2319/022 ,  B01D2319/06

摘要： Provided is a multi-functional filter including a first filter and a second filter to purify a biological fluid, a housing defining an adsorption section outside of the first filter and the second filter, a flow partitioning connector connecting the first filter and the second filter, and a housing port allowing a fluid to flow through the adsorption section. The housing may comprise a wall, a first cap coupled to the first filter at one end of the wall along a longitudinal direction, and a second cap coupled to the second filter at the other end of the wall along a longitudinal direction. The multi-functional filter according to the present invention in which dialysis, adsorption, and plasma separation or ultrafiltration are integrated to purify blood or dialysate and the internal flow is facilitated may provide a blood purifying apparatus that simplifies the whole apparatus, provides convenience in installation and use, and reduces a treatment cost.

公开(公告)号：US20160367743A1

公开(公告)日：2016-12-22

申请号：US14901881

申请日：2014-07-09

申请人： GAMBRO LUNDIA AB

发明人： Olof Jansson

IPC分类号： A61M1/16 ,  A61M1/34

CPC分类号： A61M1/1615 ,  A61M1/16 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3413 ,  A61M2205/12 ,  A61M2205/3334 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3389 ,  A61M2205/3396 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2205/702 ,  F04B49/065 ,  F04B51/00

摘要： A control unit (30) is arranged to control a dialysis fluid distribution system (12) comprising first and second volumetric pumps (P1, P2) arranged upstream and downstream of a dialyzer (13). The control unit (30) is operable in a calibration mode, to establish a bypass flow path that bypasses the dialyzer (13) and extends from the first pump (P1) to the second pump (P2) in fluid communication with a calibration chamber (26) and to operate the pumps (P1, P2) at different combinations of speeds that cause first and second changes in fluid level in the chamber (26). The first and second changes correspond to first and second known volumes in the chamber (26). The control unit (30) measures, by a level detector (28) in the chamber (26), first and second time periods for the first and second changes, and computes the stroke volumes of the pumps (P1, P2) as a function of the speeds of the pumps (P1, P2), the first and second time periods, and the first and second known volumes. By computing the stroke volumes, the control unit (30) is operable to achieve an accurate ultrafiltration (UF) rate in the dialyzer (13) by controlling the relative speeds of the pumps (P1, P2).

摘要翻译： 控制单元（30）被布置成控制透析流体分配系统（12），其包括布置在透析器（13）上游和下游的第一和第二体积泵（P1，P2）。 控制单元（30）可在校准模式下操作，以建立绕过透析器（13）并从第一泵（P1）延伸到第二泵（P2）的旁路流动路径与校准室流体连通 并且以不同的速度组合来操作泵（P1，P2），这些组合引起腔室（26）中的液位的第一和第二变化。 第一和第二改变对应于腔室（26）中的第一和第二已知体积。 控制单元（30）通过室（26）中的液位检测器（28）测量用于第一和第二变化的第一和第二时间段，并且将泵（P1，P2）的行程体积计算为函数 泵（P1，P2）的速度，第一和第二时间段以及第一和第二已知体积的速度。 通过计算行程体积，控制单元（30）可操作以通过控制泵（P1，P2）的相对速度来实现透析器（13）中的精确超滤（UF）速率。

公开(公告)号：US20160339162A1

公开(公告)日：2016-11-24

申请号：US15225712

申请日：2016-08-01

申请人： James R. CURTIS ,  Ladislaus F. NONN ,  Julie WRAZEL

发明人： James R. CURTIS ,  Ladislaus F. NONN ,  Julie WRAZEL

IPC分类号： A61M1/16 ,  G05D7/06

CPC分类号： A61M1/1647 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3413 ,  A61M1/3427 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/70 ,  A61M2205/702 ,  G05D7/0676

摘要： Systems and methods are disclosed for performing hemodialysis that include fluid handling systems that provide accurate control over the type and level of hemodialysis being performed. The system includes a first pump for pumping dialysate into a dialyzer and a second pump for pumping dialysate out of the dialyzer. The system also includes a third pump that provides improved control of a level of ultrafiltration, hemodiafiltration, or both.

摘要翻译： 公开了用于执行血液透析的系统和方法，其包括提供对正在执行的血液透析的类型和水平的精确控制的流体处理系统。 该系统包括用于将透析液泵入透析器的第一泵和用于将透析液泵出透析器的第二泵。 该系统还包括第三泵，其提供对超滤水平，血液透析滤液或两者的改进的控制。

公开(公告)号：US09393358B2

公开(公告)日：2016-07-19

申请号：US13559873

申请日：2012-07-27

申请人： Soeren Gronau ,  Joachim Manke ,  Ralf Mueller ,  Ingo Schaefer

发明人： Soeren Gronau ,  Joachim Manke ,  Ralf Mueller ,  Ingo Schaefer

IPC分类号： A61M1/34

CPC分类号： A61M1/1621 ,  A61M1/14 ,  A61M1/1605 ,  A61M1/34 ,  A61M1/3413 ,  A61M1/3434 ,  A61M1/3607 ,  A61M39/24 ,  A61M2205/12 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/27 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/70

摘要： The invention relates to a method for testing at least one function of a medical functional device which is inserted in and connected and compressed with a medical treatment apparatus, and/or a function of this treatment apparatus, wherein between a hydraulic device or a pneumatic unit of the treatment apparatus and the functional device at least one fluid communication is established. It further relates to a detection device which is programmed and/or configured for executing the method according to the invention as well as a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

公开(公告)号：US20160151554A1

公开(公告)日：2016-06-02

申请号：US14904307

申请日：2014-07-09

申请人： GAMBRO LUNDIA AB

发明人： Olof Jansson ,  Christian Vartia

IPC分类号： A61M1/16 ,  G05B15/02

CPC分类号： A61M1/1601 ,  A61M1/16 ,  A61M1/1645 ,  A61M1/1647 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M2205/12 ,  A61M2205/15 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3389 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2205/702 ,  F04B13/00 ,  F04B23/06 ,  F04B49/065 ,  F04B51/00 ,  G05B15/02

摘要： A control unit (30) is arranged to control a dialysis fluid distribution system (12) comprising two volumetric pumps (P1, P2) and a dialyzer (13). The control unit (30) is operable in a calibration mode, to establish a bypass flow path that bypasses the dialyzer (13) and extends between the pumps (P1, P2) and to operate the pumps (P1, P2) at first and second calibration speeds so as to balance the flow rates generated by the pumps (P1, P2), e.g. based on a measured pressure or fluid level in dialysis fluid distribution system (12). The control unit (30) determines, based on the first and second calibration speeds, a relation between the stroke volumes of the pumps (P1, P2). The control unit (30) is further operable in a treatment mode, to establish a main flow path that extends between the first and second pumps (P1, P2) via the dialyzer (13) and to control the first and second pumps (P1, P2), based on the relation between their stroke volumes, to operate at a respective treatment frequency so as to generate a selected ultrafiltration rate in the dialyzer (13).

摘要翻译： 控制单元（30）被布置成控制包括两个体积泵（P1，P2）和透析器（13）的透析流体分配系统（12）。 控制单元（30）可在校准模式下操作，以建立绕过透析器（13）并在泵（P1，P2）之间延伸并在第一和第二处操作泵（P1，P2）的旁路流动路径 校准速度以平衡由泵（P1，P2）产生的流量，例如 基于透析流体分配系统（12）中测量的压力或液体水平。 控制单元（30）基于第一和第二校准速度确定泵（P1，P2）的行程容积之间的关系。 控制单元（30）还可在处理模式下操作，以建立经由透析器（13）在第一和第二泵（P1，P2）之间延伸的主流路，并且控制第一和第二泵（P1， P2），基于它们的行程体积之间的关系，以相应的治疗频率操作，以便在透析器（13）中产生选定的超滤速率。