公开(公告)号：US07993258B2

公开(公告)日：2011-08-09

申请号：US11430878

申请日：2006-05-10

申请人： Yair Feld ,  Shay Dubi

发明人： Yair Feld ,  Shay Dubi

IPC分类号： A61N1/362

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/064 ,  A61B2017/048 ,  A61F2/2487 ,  A61F2002/249 ,  A61F2002/30079 ,  A61F2210/009

摘要： A method and device featuring at least one component providing a potential to kinetic converted elastic, magnetic repulsion, or, an elastic and magnetic repulsion, pushing, pulling, or, pulling and pushing, type of radially outward expansive force or pressure to an inner, outer, intermediate, and, combination thereof, wall region of the left ventricle, for reducing intraluminal hydrostatic pressure of the left ventricle (LV filling pressure) during the ventricular diastolic stage of the cardiac cycle, thereby, improving diastolic function of the left ventricle of the heart in subjects having a condition of diastolic heart failure (DHF), while minimally disturbing systolic function of the heart. The expansive force or pressure is in a range of about 5-40 mm Hg, whereby, left ventricular end diastolic pressure (LVEDP) is reduced down to the normal range of about 6-12 mm Hg, during ventricular diastole of the heart.

摘要翻译： 一种方法和装置，其特征在于至少一个部件提供动力转换的弹性，磁性排斥，或弹性和磁性排斥，推动，拉动或拉动和推动径向向外的膨胀力或压力的类型到内部， 外部，中间和组合的左心室的壁区域，用于在心脏周期的心室舒张期期间降低左心室的腔内静水压（LV填充压力），由此改善左心室舒张功能 具有舒张性心力衰竭病症（DHF）的受试者的心脏，同时心脏的收缩功能最小化。 膨胀力或压力在约5-40mm Hg的范围内，由此，在心脏心室舒张期间，左心室舒张末期压（LVEDP）降低至约6-12mm Hg的正常范围。

公开(公告)号：US07186210B2

公开(公告)日：2007-03-06

申请号：US10353085

申请日：2003-01-29

申请人： Yair Feld ,  Shay Dubi

发明人： Yair Feld ,  Shay Dubi

IPC分类号： A61M1/12 ,  A61M1/10

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/064 ,  A61B2017/048 ,  A61F2/2487 ,  A61F2002/249 ,  A61F2002/30079 ,  A61F2210/009

摘要： A method and device featuring at least one component providing a potential to kinetic converted elastic, magnetic repulsion, or, an elastic and magnetic repulsion, pushing, pulling, or, pulling and pushing, type of radially outward expansive force or pressure to an inner, outer, intermediate, and, combination thereof, wall region of the left ventricle, for reducing intraluminal hydrostatic pressure of the left ventricle (LV filling pressure) during the ventricular diastolic stage of the cardiac cycle, thereby, improving diastolic function of the left ventricle of the heart in subjects having a condition of diastolic heart failure (DHF), while minimally disturbing systolic function of the heart. The expansive force or pressure is in a range of about 5–40 mm Hg, whereby, left ventricular end diastolic pressure (LVEDP) is reduced down to the normal range of about 6–12 mm Hg, during ventricular diastole of the heart.

摘要翻译： 一种方法和装置，其特征在于至少一个部件提供动力转换的弹性，磁性排斥，或弹性和磁性排斥，推动，拉动或拉动和推动径向向外的膨胀力或压力的类型到内部， 外部，中间和组合的左心室的壁区域，用于在心脏周期的心室舒张期期间降低左心室的腔内静水压（LV填充压力），由此改善左心室舒张功能 具有舒张性心力衰竭病症（DHF）的受试者的心脏，同时心脏的收缩功能最小化。 膨胀力或压力在约5-40mm Hg的范围内，由此，在心脏心室舒张期间，左心室舒张末期压（LVEDP）降低至约6-12mm Hg的正常范围。

公开(公告)号：US20060276683A1

公开(公告)日：2006-12-07

申请号：US11430878

申请日：2006-05-10

申请人： Yair Feld ,  Shay Dubi

发明人： Yair Feld ,  Shay Dubi

IPC分类号： A61M1/12

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/00491 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/064 ,  A61B2017/048 ,  A61F2/2487 ,  A61F2002/249 ,  A61F2002/30079 ,  A61F2210/009

摘要： A method and device featuring at least one component providing a potential to kinetic converted elastic, magnetic repulsion, or, an elastic and magnetic repulsion, pushing, pulling, or, pulling and pushing, type of radially outward expansive force or pressure to an inner, outer, intermediate, and, combination thereof, wall region of the left ventricle, for reducing intraluminal hydrostatic pressure of the left ventricle (LV filling pressure) during the ventricular diastolic stage of the cardiac cycle, thereby, improving diastolic function of the left ventricle of the heart in subjects having a condition of diastolic heart failure (DHF), while minimally disturbing systolic function of the heart. The expansive force or pressure is in a range of about 5-40 mm Hg, whereby, left ventricular end diastolic pressure (LVEDP) is reduced down to the normal range of about 6-12 mm Hg, during ventricular diastole of the heart.

摘要翻译： 一种方法和装置，其特征在于至少一个部件提供动力转换的弹性，磁性排斥，或弹性和磁性排斥，推动，拉动或拉动和推动径向向外的膨胀力或压力的类型到内部， 外部，中间和组合的左心室的壁区域，用于在心脏周期的心室舒张期期间降低左心室的腔内静水压（LV填充压力），由此改善左心室舒张功能 具有舒张性心力衰竭病症（DHF）的受试者的心脏，同时心脏的收缩功能最小化。 膨胀力或压力在约5-40mm Hg的范围内，由此，在心脏心室舒张期间，左心室舒张末期压（LVEDP）降低至约6-12mm Hg的正常范围。

公开(公告)号：US20060241334A1

公开(公告)日：2006-10-26

申请号：US10543406

申请日：2004-01-26

申请人： Shay Dubi ,  Yair Feld

发明人： Shay Dubi ,  Yair Feld

IPC分类号： A61N1/362

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/0401 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/0441 ,  A61B2017/0496

摘要： The present invention provides an in vivo device for improving diastolic function of the heart, comprising: at least one elastic component that may be operatively connected to the external surface of the left or right ventricle of the heart by means of connecting elements, wherein said elastic component comprises essentially longitudinal members arranged such that the lateral separation therebetween may be increased or decreased in response to elastic deformation of said elastic component, and wherein said essentially longitudinal members are arranged such that said elastic component is curved in both the vertical and horizontal planes, such that its inner surface may be adapted to the curvature of the external ventricular surface of the heart, such that said elastic component is capable of exerting both radially outward expansive and tangentially-directed forces on the external surface of the cardiac ventricle.

摘要翻译： 本发明提供一种用于改善心脏舒张功能的体内装置，包括：至少一个弹性部件，其可通过连接元件与心脏的左心室或右心室的外表面可操作地连接，其中所述弹性 组件包括基本纵向构件，其布置成使得它们之间的横向分离可以响应于所述弹性构件的弹性变形而增加或减小，并且其中所述基本上纵向构件布置成使得所述弹性构件在垂直和水平面中均弯曲， 使得其内表面可以适应于心脏的外部心室表面的曲率，使得所述弹性部件能够在心室的外表面上施加径向向外的膨胀和切向力。

公开(公告)号：US08382653B2

公开(公告)日：2013-02-26

申请号：US12311222

申请日：2007-09-25

申请人： Shay Dubi ,  Igor Kovalsky ,  Yair Feld ,  Amir Loshakove ,  Boaz Nishri ,  Amit Tubishevitz

发明人： Shay Dubi ,  Igor Kovalsky ,  Yair Feld ,  Amir Loshakove ,  Boaz Nishri ,  Amit Tubishevitz

IPC分类号： A61F2/00 ,  A61F13/00

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61F2002/2484 ,  A61F2250/0067

摘要： The present invention provides a system for improving diastolic function of the heart comprising elastic elements and attachment elements, wherein said elastic elements and said attachment elements are configured such that they are capable of being interconnected to form a chain formed of an alternating series of said elastic elements and said attachment elements, and wherein said attachment elements are adapted to be anchored in the wall of the heart and with option for drug delivery to the wall of the heart. The invention further provides devices, methods and kits, for mounting the ventricular function assisting device of the invention.

摘要翻译： 本发明提供了一种用于改善包括弹性元件和附接元件的心脏的舒张功能的系统，其中所述弹性元件和所述附接元件构造成使得它们能够互连以形成由交替的一系列所述弹性体 元件和所述附接元件，并且其中所述附接元件适于锚定在心脏的壁中并且具有药物递送至心脏壁的选项。 本发明还提供了用于安装本发明的心室功能辅助装置的装置，方法和试剂盒。

公开(公告)号：US20100022821A1

公开(公告)日：2010-01-28

申请号：US12311222

申请日：2007-09-25

申请人： Shay Dubi ,  Igor Kovalsky ,  Yair Feld ,  Amir Loshakove ,  Boaz Nishri ,  Amit Tubishevitz

发明人： Shay Dubi ,  Igor Kovalsky ,  Yair Feld ,  Amir Loshakove ,  Boaz Nishri ,  Amit Tubishevitz

IPC分类号： A61F2/02

CPC分类号： A61F2/2481 ,  A61B17/00234 ,  A61B17/0401 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61F2002/2484 ,  A61F2250/0067

摘要： The present invention provides a system for improving diastolic function of the heart comprising elastic elements and attachment elements, wherein said elastic elements and said attachment elements are configured such that they are capable of being interconnected to form a chain formed of an alternating series of said elastic elements and said attachment elements, and wherein said attachment elements are adapted to be anchored in the wall of the heart and with option for drug delivery to the wall of the heart. The invention further provides devices, methods and kits, for mounting the ventricular function assisting device of the invention.

摘要翻译： 本发明提供了一种用于改善包括弹性元件和附接元件的心脏的舒张功能的系统，其中所述弹性元件和所述附接元件构造成使得它们能够互连以形成由交替的一系列所述弹性体 元件和所述附接元件，并且其中所述附接元件适于锚定在心脏的壁中并且具有药物递送至心脏壁的选项。 本发明还提供了用于安装本发明的心室功能辅助装置的装置，方法和试剂盒。

公开(公告)号：US08652102B2

公开(公告)日：2014-02-18

申请号：US13439043

申请日：2012-04-04

申请人： David Nitsan ,  Shay Dubi

发明人： David Nitsan ,  Shay Dubi

IPC分类号： A61M37/00

CPC分类号： A61M3/0283 ,  A61B1/31

摘要： The present invention may provide devices suitable for insertion into a body passage. The devices may include a conduit and a distal head region located at the distal end of said conduit. A plurality of apertures on the surface of said head region and conduit may be used to direct a liquid spray outwards from said device. The apertures may be designed and spatially arranged such that when the device is inserted into a body passage, the liquid spray emitted from said apertures may be capable of both reducing the frictional contact between the device and the walls of said passage and of cleansing said passage of undesired solid and other particulate matter.

摘要翻译： 本发明可以提供适于插入身体通道的装置。 所述装置可以包括位于所述导管的远端处的导管和远侧头部区域。 所述头部区域和导管表面上的多个孔可用于将液体喷雾从所述装置向外引导。 孔可以被设计和空间地布置，使得当装置插入体通道中时，从所述孔排出的液体喷雾可能既能减少装置与所述通道的壁之间的摩擦接触，也可以清洁所述通道 的不期望的固体和其他颗粒物质。

公开(公告)号：US08556851B2

公开(公告)日：2013-10-15

申请号：US11477812

申请日：2006-06-30

申请人： Eran Hirszowicz ,  Shay Dubi

发明人： Eran Hirszowicz ,  Shay Dubi

IPC分类号： A61M29/00 ,  A61M31/00

CPC分类号： A61M25/1006 ,  A61M25/0119 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1015 ,  A61M2025/1068 ,  A61M2025/109

摘要： A catheter system suitable for the retrieval of debris and other solid or liquid matter from body passages, and the removal of said matter from the body. More particularly, a catheter system including two or more concentrically-arranged conduits and an inflatable element connected therebetween, wherein the inflatable element is arranged such that it may entrap solid or liquid matter in an internal annular cavity.

摘要翻译： 一种导管系统，适用于从身体通道中取出碎屑和其他固体或液体物质，并从体内去除所述物质。 更具体地，包括两个或多个同心布置的管道和连接在其间的可充气元件的导管系统，其中可膨胀元件被布置成使得其可以将固体或液体物质捕获在内部环形空腔中。

公开(公告)号：US20090254114A1

公开(公告)日：2009-10-08

申请号：US12338755

申请日：2008-12-18

申请人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

发明人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

IPC分类号： A61M25/10

CPC分类号： A61M25/1006 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/0119 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1065 ,  A61M2025/1068

摘要： The present invention provides a balloon catheter comprising: a hollow inner shaft disposed within a hollow outer shaft; a balloon attached at its proximal end to said outer shaft and at its distal end to said inner shaft; wherein the inner shaft is constructed such that following radial expansion of the balloon to a first expanded state, said inner shaft is capable of responding to further longitudinal expansion of the balloon to a second expanded state by increasing its length from a resting value, and of responding to subsequent partial deflation back to said first expanded state by reducing its length back to said resting value.

摘要翻译： 本发明提供一种球囊导管，包括：设置在中空外轴内的中空内轴; 在其近端处附接到所述外轴并且其远端附接到所述内轴的气囊; 其中所述内轴被构造成使得随着所述球囊的径向膨胀到第一膨胀状态，所述内轴能够通过从静止值增加其长度来响应气囊的进一步纵向膨胀到第二膨胀状态，并且 通过将其长度减小到所述静止值来响应随后的部分收缩回到所述第一扩张状态。

公开(公告)号：US08197505B2

公开(公告)日：2012-06-12

申请号：US12292597

申请日：2008-11-21

申请人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

发明人： Eran Hirszowicz ,  Eran Levit ,  Shay Dubi

IPC分类号： A61M29/00

CPC分类号： A61M25/1006 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/0119 ,  A61M25/1002 ,  A61M25/104 ,  A61M2025/0183 ,  A61M2025/1065 ,  A61M2025/1068

摘要： The present invention provides a balloon catheter comprising: a hollow inner shaft disposed within a hollow outer shaft; a balloon attached at its proximal end to said outer shaft and at its distal end to said inner shaft; wherein the inner shaft is constructed such that following radial expansion of the balloon to a first expanded state, said inner shaft is capable of responding to further longitudinal expansion of the balloon to a second expanded state by increasing its length from a resting value, and of responding to subsequent partial deflation back to said first expanded state by reducing its length back to said resting value.

摘要翻译： 本发明提供一种球囊导管，包括：设置在中空外轴内的中空内轴; 在其近端处附接到所述外轴并且其远端附接到所述内轴的气囊; 其中所述内轴被构造成使得随着所述球囊的径向膨胀到第一膨胀状态，所述内轴能够通过从静止值增加其长度来响应气囊的进一步纵向膨胀到第二膨胀状态，并且 通过将其长度减小到所述静止值来响应随后的部分收缩回到所述第一扩张状态。