专利检索 ap:("Yale University") AND inv:"Michael Mak" 第 1 页

1.

发明公开
MECHANOCHEMICAL GENERATION OF NOVEL COLLAGEN GEL ARCHITECTURES AND SCAFFOLDS 审中-公开

公开(公告)号：US20240166723A1

公开(公告)日：2024-05-23

申请号：US18503544

申请日：2023-11-07

申请人： Yale University

发明人： Michael Mak , Chang Liu , Ryan Nguyen

IPC分类号： C07K14/78 , C07K1/113

CPC分类号： C07K14/78 , C07K1/113

摘要： A method of generating thickened collagen bundles or clusters, comprising the steps of: preparing a neutralized collagen gel sample; warming the neutralized collagen gel sample to provide a warmed neutralized collagen gel sample; and agitating the warmed neutralized collagen gel sample to provide an agitated collagen gel sample.

2.

发明公开
Rapidly synthesized extracellular matrix-based gels and patterning techniques, from micro- to macro-scale 审中-公开

公开(公告)号：US20230381373A1

公开(公告)日：2023-11-30

申请号：US18317526

申请日：2023-05-15

申请人： Yale University

发明人： Michael Mak , Xiangyu Gong

IPC分类号： A61L27/24 , A61L27/26 , A61L27/50

CPC分类号： A61L27/24 , A61L27/26 , A61L27/507 , A61L2430/20 , A61L2430/40

摘要： In some aspects, the present invention provides a method of forming crowded collagen based constructs, having the steps of providing a collagen solution in a buffer, providing a macromolecular bath solution, and delivering the collagen solution into the macromolecular bath solution to form crowded collagen constructs. In other aspects, the present invention provides a method of forming crowded cellular based constructs, having the steps of providing a cellular solution in a buffer, providing a macromolecular bath solution, and delivering the cellular solution into the macromolecular bath solution to form crowded cellular constructs.