公开(公告)号：US10293090B2

公开(公告)日：2019-05-21

申请号：US14695750

申请日：2015-04-24

申请人： Yale University

发明人： Pramod Bonde ,  Brian Letzen

IPC分类号： A61M1/10 ,  A61M1/12

摘要： The present invention provides a minimally-invasive percutaneous device that can be positioned within the body of a subject to aid in the movement or pumping of a bodily fluid. In one embodiment, the device comprises a plurality of pump units configured to transform from a first compressed configuration where the pump units are organized in a serial arrangement into a second expanded configuration where the pump units are reorganized into a parallel arrangement.

公开(公告)号：US20190111196A1

公开(公告)日：2019-04-18

申请号：US16218520

申请日：2018-12-13

申请人： YALE UNIVERSITY

发明人： Pramod Bonde

IPC分类号： A61M1/10 ,  A61M25/10

摘要： The present invention relates to systems and methods for in situ inspection, interrogation, and maintenance of heart pump function in subjects with an implanted heart pump. In certain embodiments, the system comprises a catheter assembly deliverable to the inflow port and outflow port of the implanted heart pump. The system comprises additional components used to examine pump function and prevent malfunction. In certain embodiments, the invention allows for temporary, mid-term, or permanent exclusion of the implanted heart pump from cardiac function without surgically removing the pump.

公开(公告)号：US20150306291A1

公开(公告)日：2015-10-29

申请号：US14695750

申请日：2015-04-24

申请人： Yale University

发明人： Pramod Bonde ,  Brian Letzen

IPC分类号： A61M1/12 ,  A61M1/10

CPC分类号： A61M1/122 ,  A61M1/101 ,  A61M1/1015 ,  A61M1/1029 ,  A61M1/1031 ,  A61M1/1034 ,  A61M1/125 ,  A61M2205/0266

摘要： The present invention provides a minimally-invasive percutaneous device that can be positioned within the body of a subject to aid in the movement or pumping of a bodily fluid. In one embodiment, the device comprises a plurality of pump units configured to transform from a first compressed configuration where the pump units are organized in a serial arrangement into a second expanded configuration where the pump units are reorganized into a parallel arrangement.

摘要翻译： 本发明提供一种微创经皮装置，其可以定位在受试者的身体内以有助于运动或泵送体液。 在一个实施例中，该装置包括多个泵单元，其被配置为从第一压缩配置变换，其中泵单元以串行排列组织成第二扩展配置，其中泵单元被重组成平行布置。

公开(公告)号：US20220202571A1

公开(公告)日：2022-06-30

申请号：US17609241

申请日：2020-05-07

申请人： YALE UNIVERSITY

发明人： Pramod Bonde

IPC分类号： A61F2/24 ,  A61F2/848

摘要： The present invention provides ventricular restoration devices and snare devices as part of a papillary muscle approximation and ventricular restoration (PAP-VR) system and methods for using the same to repair mitral regurgitation (MR). The ventricular restoration devices include two collapsible anchors positioned at opposing ends of a collapsible stent, wherein the devices are threaded through a subject's anatomy such that the anchors rest outside of tissue and are held taut by the stent inbetween. The snare devices comprise an out-of-plane curved construction to navigate magnetized trapping lines around difficult to reach anatomy to lasso and tighten anatomical structures.

公开(公告)号：US20210154464A1

公开(公告)日：2021-05-27

申请号：US16984580

申请日：2020-08-04

申请人： Yale University

发明人： Pramod Bonde

IPC分类号： A61M60/871 ,  A61M60/40 ,  A61M60/148 ,  A61M60/892 ,  A61M60/894

摘要： A heart failure recovery device includes a fluid pump having an inlet and an outlet in fluid communication with a pump reservoir, and a pumping element disposed within the pump reservoir, the pumping element including a protrusion that in an active state is configured to rotate and move fluid away from the inlet and towards the outlet. A receiver coil can be electrically coupled to the fluid pump and is configured to subcutaneously absorb electromagnetic energy for powering the fluid pump. In certain embodiments, an implantable port provides fluid access to the pump reservoir for cleaning and maintaining the fluid pump. In other embodiments, a valve closes fluid access to at least one of the inlet and the outlet during periods when the device is not being used for treatment.

公开(公告)号：US20210260359A1

公开(公告)日：2021-08-26

申请号：US17252065

申请日：2019-06-13

申请人： YALE UNIVERSITY

发明人： Pramod Bonde

IPC分类号： A61M60/135 ,  A61M60/237 ,  A61M60/422 ,  A61M60/419 ,  A61M60/892

摘要： The present invention provides intracardiac devices and methods of implanting the same. The intracardiac devices have a collapsible stent design and include an axial pump to support cardiac function. The axial pump can feature a shaftless fluid actuator for enhanced efficiency in fluid transfer while reducing blood cell trauma. The intracardiac devices include valves that are closeable to seal implanted devices from a subject's anatomy. The intracardiac devices include a cleaning system configured to introduce and circulate cleaning solutions and therapeutics to implanted devices. The intracardiac devices are wirelessly powered and controlled. The intracardiac devices can be implanted using minimally invasive procedures without the need for open heart surgery.

公开(公告)号：US20210093441A1

公开(公告)日：2021-04-01

申请号：US17061347

申请日：2020-10-01

申请人： YALE UNIVERSITY

发明人： Pramod Bonde

IPC分类号： A61F2/07 ,  A61F2/962

摘要： A system for treating aortic dissection includes a sinotubular junction magnetic array having a first plurality of magnetic elements, a counter-magnetic array having a second plurality of magnetic elements, and an ascending aortic stent graft comprising a third plurality of magnetic elements. A method for treating aortic dissection includes the steps of positioning a sinotubular junction magnetic array at the sinotubular junction, advancing counter magnetic constructs from the femoral vein and positioning them in the right atrium, expanding the sinotubular junction ring at a target position, advancing the counter magnetic array to form an at least partial circumferential seal, and advancing and positioning an ascending magnetic graft within an interior of the sinotubular junction magnetic array. A system for treating aortic dissection, a fixation device for anchoring an ascending aortic stent graft, and a transcatheter device for treating aortic dissection are also described.

公开(公告)号：US20190001037A1

公开(公告)日：2019-01-03

申请号：US15535494

申请日：2015-12-17

申请人： Yale University

发明人： Pramod Bonde

IPC分类号： A61M1/12 ,  A61M1/10

CPC分类号： A61M1/127 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/102 ,  A61M1/1029 ,  A61M1/1037 ,  A61M1/1086 ,  A61M1/1087 ,  A61M1/1096 ,  A61M1/122 ,  A61M2205/3327 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2230/04

摘要： A heart failure recovery device includes a fluid pump having an inlet and an outlet in fluid communication with a pump reservoir, and a pumping element disposed within the pump reservoir, the pumping element including a protrusion that in an active state is configured to rotate and move fluid away from the inlet and towards the outlet. A receiver coil can be electrically coupled to the fluid pump and is configured to subcutaneously absorb electromagnetic energy for powering the fluid pump. In certain embodiments, an implantable port provides fluid access to the pump reservoir for cleaning and maintaining the fluid pump. In other embodiments, a valve closes fluid access to at least one of the inlet and the outlet during periods when the device is not being used for treatment.

公开(公告)号：US20160151553A1

公开(公告)日：2016-06-02

申请号：US14858746

申请日：2015-09-18

申请人： Yale University

发明人： Pramod Bonde

IPC分类号： A61M1/10 ,  H04W12/06 ,  A61M1/12

CPC分类号： A61M1/1086 ,  A61M1/1005 ,  A61M1/101 ,  A61M1/12 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/52 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2230/06 ,  H04W12/06

摘要： The present invention provides devices, systems, and methods for control of and communication with ventricular assist devices. In certain embodiments, the invention includes an implantable controller that is operatively programmed to direct physiological flow through a ventricular assist device that can be substantially synchronized to the cardiac cycle of the subject. In certain embodiments, the implantable controller is also communicatively connected to an external control unit, such that the implantable controller can transmit data to the external control unit, and instructions can be sent from the external control unit to the implantable controller. In certain embodiments, a system and method for secure communication between a remote device and the implanted ventricular assist device is provided.

摘要翻译： 本发明提供了用于控制和与心室辅助装置通信的装置，系统和方法。 在某些实施例中，本发明包括可植入控制器，该可植入控制器可操作地编程为将生理流量引导通过心室辅助装置，所述心室辅助装置可基本上同步于受试者的心脏周期。 在某些实施例中，可植入控制器还可通信地连接到外部控制单元，使得可植入控制器可以向外部控制单元发送数据，并且指令可以从外部控制单元发送到可植入控制器。 在某些实施例中，提供了一种用于远程设备和植入式心室辅助装置之间的安全通信的系统和方法。

公开(公告)号：US10729834B2

公开(公告)日：2020-08-04

申请号：US15535494

申请日：2015-12-17

申请人： Yale University

发明人： Pramod Bonde

IPC分类号： A61M1/12 ,  A61M1/10

摘要： A heart failure recovery device includes a fluid pump having an inlet and an outlet in fluid communication with a pump reservoir, and a pumping element disposed within the pump reservoir, the pumping element including a protrusion that in an active state is configured to rotate and move fluid away from the inlet and towards the outlet. A receiver coil can be electrically coupled to the fluid pump and is configured to subcutaneously absorb electromagnetic energy for powering the fluid pump. In certain embodiments, an implantable port provides fluid access to the pump reservoir for cleaning and maintaining the fluid pump. In other embodiments, a valve closes fluid access to at least one of the inlet and the outlet during periods when the device is not being used for treatment.