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公开(公告)号：US08414684B2
公开(公告)日：2013-04-09
申请号：US12791732
申请日：2010-06-01
申请人： Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
发明人： Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
CPC分类号： B01D19/0073 , B01D19/0031 , B01D19/0036 , G01N30/32 , G01N30/96 , G01N2030/146
摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.
摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。
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公开(公告)号：US20110290726A1
公开(公告)日：2011-12-01
申请号：US12791732
申请日：2010-06-01
申请人： Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
发明人： Yan Liu , Christopher A. Pohl , Michael McAdams , Hamish Small , Zhongqing Lu , Milton Liu , Khosro Moshfegh
IPC分类号： B01D19/00
CPC分类号： B01D19/0073 , B01D19/0031 , B01D19/0036 , G01N30/32 , G01N30/96 , G01N2030/146
摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.
摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。
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公开(公告)号：US08802011B2
公开(公告)日：2014-08-12
申请号：US13905548
申请日：2013-05-30
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译： 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。
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公开(公告)号：US20090289009A1
公开(公告)日：2009-11-26
申请号：US12511788
申请日：2009-07-29
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译： 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。
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公开(公告)号：US20090211980A1
公开(公告)日：2009-08-27
申请号：US12036147
申请日：2008-02-22
IPC分类号： B01D15/08
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译： 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。
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公开(公告)号：US20110174737A1
公开(公告)日：2011-07-21
申请号：US13075009
申请日：2011-03-29
IPC分类号： B01D15/08
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译： 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。
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公开(公告)号：US08802010B2
公开(公告)日：2014-08-12
申请号：US13905516
申请日：2013-05-30
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
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公开(公告)号：US08465982B2
公开(公告)日：2013-06-18
申请号：US13075009
申请日：2011-03-29
IPC分类号： G01N30/02
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
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公开(公告)号：US07585679B1
公开(公告)日：2009-09-08
申请号：US12036147
申请日：2008-02-22
IPC分类号： G01N30/02
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译： 一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱 分离柱。 检测器和腔室之间的停留时间至少约1分钟。 此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。 此外，在检测器和室之间施加热或UV能量。 另外，在室后检测气泡。 此外，铂族金属催化剂和离子交换介质在室内。 用于执行方法的装置。
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10.发明申请公开(公告)号：US20110054155A1
公开(公告)日：2011-03-03
申请号：US12549444
申请日：2009-08-28
申请人： Zhongqing Lu
发明人： Zhongqing Lu
IPC分类号： C07J43/00
CPC分类号： C07J17/005
摘要： This invention relates to a technology used for a fast separation of Ginsenoside Re directly from other ginsensosides with similar molecular structures. In a conventional method, multiple steps and complex organic mobile phases are required to obtain a highly purified Ginsenoside Re compound, which are time consuming and organic solvent consumption, an obstacle for large scale industrial production. In our new technology, a quick separation for a mixture of two compounds with similar molecular structure. Ginsenoside Re and Ginsenoside Rg1 was demonstrated through a Surpass™ PolyGin-Re column 2×250 mm, in which only methanol was used for elution, no acids or bases were needed, which could be a Green technology for Ginsenoside Re production in the future.
摘要翻译： 本发明涉及一种用于快速分离人参皂苷Re的直接与其他具有相似分子结构的人参皂苷的技术。 在常规方法中，需要多个步骤和复杂的有机流动相来获得高度纯化的人参皂苷Re化合物，这是耗时且有机溶剂消耗的大规模工业生产的障碍。 在我们的新技术中，快速分离具有相似分子结构的两种化合物的混合物。 人参皂甙Re和人参皂甙Rg1通过2×250mm的Surpass™PolyGin-Re柱证实，其中仅使用甲醇洗脱，不需要酸或碱，这可能是未来人参皂苷再生产的绿色技术。
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