公开(公告)号：US08449658B2

公开(公告)日：2013-05-28

申请号：US13027148

申请日：2011-02-14

申请人： Michael McAdams ,  Milton Liu ,  Gary L. Gleave

发明人： Michael McAdams ,  Milton Liu ,  Gary L. Gleave

IPC分类号： B01D53/22 ,  B01D19/00

CPC分类号： B01D19/0031 ,  B01D15/361 ,  B01D19/0036 ,  B01D19/0063 ,  G01N30/26 ,  G01N30/34 ,  G01N30/96 ,  G01N2030/146

摘要： A high-pressure capillary degas assembly includes an assembly block having an eluent inlet and an eluent outlet, and a separator support extending therebetween, a wash inlet and a wash outlet and a groove extending therebetween, a tubular separator extending within the assembly block, the separator having an inner surface and an outer surface, the inner surface defining an eluent fluid line fluidly interconnecting the eluent inlet and outlet, the outer surface abutting against the separator support and enclosing the groove to define a wash line within the groove. The separator may be configured to retain liquid in the eluent fluid line at a first pressure and allow gas to flow through the separator to the wash fluid line at a second pressure lower than the first pressure. A method of using the high-pressure capillary degas assembly is also disclosed.

摘要翻译： 高压毛细管脱气组件包括具有洗脱剂入口和​​洗脱液出口的组装块和在其间延伸的分离器支撑件，洗涤入口和洗涤出口以及在其间延伸的凹槽，在组件块内延伸的管状分离器， 分离器具有内表面和外表面，内表面限定了洗脱液流体管线，其将洗脱液入口和出口流体地互连，外表面抵靠分离器支撑件并且包围凹槽以在凹槽内限定洗涤线。 分离器可以被配置为在第一压力下将液体保持在洗脱液流体管线中，并且允许气体以低于第一压力的第二压力流过分离器至洗涤流体管线。 还公开了使用高压毛细管脱气组件的方法。

公开(公告)号：US08414684B2

公开(公告)日：2013-04-09

申请号：US12791732

申请日：2010-06-01

申请人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

发明人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

IPC分类号： B01D53/22 ,  B01D19/00

CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

公开(公告)号：US20120204726A1

公开(公告)日：2012-08-16

申请号：US13027148

申请日：2011-02-14

申请人： Michael McAdams ,  Milton Liu ,  Gary L. Gleave

发明人： Michael McAdams ,  Milton Liu ,  Gary L. Gleave

IPC分类号： B01D19/00 ,  B01D15/08

CPC分类号： B01D19/0031 ,  B01D15/361 ,  B01D19/0036 ,  B01D19/0063 ,  G01N30/26 ,  G01N30/34 ,  G01N30/96 ,  G01N2030/146

摘要： A high-pressure capillary degas assembly includes an assembly block having an eluent inlet and an eluent outlet, and a separator support extending therebetween, a wash inlet and a wash outlet and a groove extending therebetween, a tubular separator extending within the assembly block, the separator having an inner surface and an outer surface, the inner surface defining an eluent fluid line fluidly interconnecting the eluent inlet and outlet, the outer surface abutting against the separator support and enclosing the groove to define a wash line within the groove. The separator may be configured to retain liquid in the eluent fluid line at a first pressure and allow gas to flow through the separator to the wash fluid line at a second pressure lower than the first pressure. A method of using the high-pressure capillary degas assembly is also disclosed.

摘要翻译： 高压毛细管脱气组件包括具有洗脱剂入口和​​洗脱液出口的组装块和在其间延伸的分离器支撑件，洗涤入口和洗涤出口以及在其间延伸的凹槽，在组件块内延伸的管状分离器， 分离器具有内表面和外表面，内表面限定了洗脱液流体管线，其将洗脱液入口和出口流体地互连，外表面抵靠分离器支撑件并且包围凹槽以在凹槽内限定洗涤线。 分离器可以被配置为在第一压力下将液体保持在洗脱液流体管线中，并且允许气体以低于第一压力的第二压力流过分离器至洗涤流体管线。 还公开了使用高压毛细管脱气组件的方法。

公开(公告)号：US20110290726A1

公开(公告)日：2011-12-01

申请号：US12791732

申请日：2010-06-01

申请人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

发明人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

IPC分类号： B01D19/00

CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

公开(公告)号：US20100224012A1

公开(公告)日：2010-09-09

申请号：US12399786

申请日：2009-03-06

申请人： Walter D. MODIC ,  Michael McADAMS ,  Lawrence T. McNARY ,  Trung K. HUYNH ,  Christopher A. POHL ,  Frank HOEFLER

发明人： Walter D. MODIC ,  Michael McADAMS ,  Lawrence T. McNARY ,  Trung K. HUYNH ,  Christopher A. POHL ,  Frank HOEFLER

IPC分类号： G01N1/20 ,  B01D29/00 ,  B01L3/00 ,  B01D37/00

CPC分类号： G01N35/025 ,  B01L3/502 ,  B01L3/5021 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N30/14 ,  G01N30/24 ,  G01N35/1016 ,  G01N2035/0441

摘要： A fluid delivery system including a filter for filtering solid particles from a liquid sample, the filter including a first filter member configured to filter solid media from a liquid sample, a second filter member fluidly connected to the first filter member, and a third filter member fluidly connected to a downstream end of the second filter member. The second filter member is configured to filter relatively smaller solid media from the liquid sample than the first filter member, and the third filter member is configured to filter relatively larger solid media from the liquid sample than the second filter member. In various aspects, the system includes a displacement-type plunger needle to draw sample fluid from a vial, a cantilevered carousel for rotatably supporting an array of sample holding vials, and a support for supporting the carousel. Method of using the fluid delivery system are also disclosed.

摘要翻译： 一种流体输送系统，包括用于从液体样品过滤固体颗粒的过滤器，所述过滤器包括构造成从液体样品过滤固体介质的第一过滤构件，与第一过滤构件流体连接的第二过滤构件和第三过滤构件 流体连接到第二过滤构件的下游端。 第二过滤构件被配置为从液体样品中过滤相对较小的固体介质而不是第一过滤构件，并且第三过滤构件被配置为从液体样品中过滤比第二过滤构件更大的固体介质。 在各个方面，该系统包括用于从小瓶中抽出样品流体的位移型柱塞针，用于可旋转地支撑样品保持小瓶阵列的悬臂式转盘和用于支撑转盘的支撑件。 还公开了使用流体输送系统的方法。

公开(公告)号：US08776621B2

公开(公告)日：2014-07-15

申请号：US12399786

申请日：2009-03-06

申请人： Walter D. Modic ,  Michael McAdams ,  Lawrence T. McNary ,  Trung K. Huynh ,  Christopher A. Pohl ,  Frank Hoefler

发明人： Walter D. Modic ,  Michael McAdams ,  Lawrence T. McNary ,  Trung K. Huynh ,  Christopher A. Pohl ,  Frank Hoefler

IPC分类号： G01N1/22

CPC分类号： G01N35/025 ,  B01L3/502 ,  B01L3/5021 ,  B01L2300/0681 ,  B01L2400/0478 ,  G01N30/14 ,  G01N30/24 ,  G01N35/1016 ,  G01N2035/0441

摘要： A fluid delivery system including a filter for filtering solid particles from a liquid sample, the filter including a first filter member configured to filter solid media from a liquid sample, a second filter member fluidly connected to the first filter member, and a third filter member fluidly connected to a downstream end of the second filter member. The second filter member is configured to filter relatively smaller solid media from the liquid sample than the first filter member, and the third filter member is configured to filter relatively larger solid media from the liquid sample than the second filter member. In various aspects, the system includes a displacement-type plunger needle to draw sample fluid from a vial, a cantilevered carousel for rotatably supporting an array of sample holding vials, and a support for supporting the carousel. Method of using the fluid delivery system are also disclosed.

摘要翻译： 一种流体输送系统，包括用于从液体样品过滤固体颗粒的过滤器，所述过滤器包括构造成从液体样品过滤固体介质的第一过滤构件，与第一过滤构件流体连接的第二过滤构件和第三过滤构件 流体连接到第二过滤构件的下游端。 第二过滤构件被配置为从液体样品中过滤相对较小的固体介质而不是第一过滤构件，并且第三过滤构件被配置为从液体样品中过滤比第二过滤构件更大的固体介质。 在各个方面，该系统包括用于从小瓶中抽出样品流体的位移型柱塞针，用于可旋转地支撑样品保持小瓶阵列的悬臂式转盘和用于支撑转盘的支撑件。 还公开了使用流体输送系统的方法。