公开(公告)号：US08414684B2

公开(公告)日：2013-04-09

申请号：US12791732

申请日：2010-06-01

申请人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

发明人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

IPC分类号： B01D53/22 ,  B01D19/00

CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

公开(公告)号：US20110290726A1

公开(公告)日：2011-12-01

申请号：US12791732

申请日：2010-06-01

申请人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

发明人： Yan Liu ,  Christopher A. Pohl ,  Michael McAdams ,  Hamish Small ,  Zhongqing Lu ,  Milton Liu ,  Khosro Moshfegh

IPC分类号： B01D19/00

CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

公开(公告)号：US20100038245A1

公开(公告)日：2010-02-18

申请号：US12192781

申请日：2008-08-15

申请人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

发明人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC分类号： B01D59/42

CPC分类号： G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

摘要： A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, a first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

摘要翻译： 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发生器室与阳极室分开，与阳极室电连通的第一电极，邻近的阴极室 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

公开(公告)号：US20120138474A1

公开(公告)日：2012-06-07

申请号：US13364078

申请日：2012-02-01

申请人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

发明人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC分类号： C25B15/02 ,  C25B1/02 ,  C25B9/00

CPC分类号： G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

摘要： A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, it first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

摘要翻译： 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发电机室与阳极隔室分离，第一电极与阳极室电连通，阴极室相邻 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

公开(公告)号：US08133373B2

公开(公告)日：2012-03-13

申请号：US12192781

申请日：2008-08-15

申请人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

发明人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC分类号： B01D61/44

CPC分类号： G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

摘要： A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, a first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

摘要翻译： 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发生器室与阳极室分开，与阳极室电连通的第一电极，邻近的阴极室 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

公开(公告)号：US08628652B2

公开(公告)日：2014-01-14

申请号：US13364078

申请日：2012-02-01

申请人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

发明人： Hamish Small ,  Yan Liu ,  Christopher A. Pohl

IPC分类号： B01D61/44

CPC分类号： G01N30/96 ,  B01D61/427 ,  F04B17/00 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095

摘要： A continuous electrochemical pump comprising a water generator compartment, an anode compartment on one side of said generator compartment, a cation exchange barrier, separating the generator compartment from the anode compartment, it first electrode in electrical communication with the anode compartment, a cathode compartment adjacent the generator chamber, an anion exchange barrier, separating the generation compartment from the cathode compartment, and a second electrode in electrical communication with the cathode compartment. Use of the pump as a sample concentrator. A feedback loop for the pump. A reservoir, with or without an intermediate piston, on the output side of the pump.

摘要翻译： 一种连续电化学泵，包括水发生器室，在所述发生器室的一侧上的阳极室，阳离子交换屏障，将发电机室与阳极隔室分离，第一电极与阳极室电连通，阴极室相邻 所述发生器室，阴离子交换屏障，将所述发电室与所述阴极室分开，以及与所述阴极室电连通的第二电极。 使用泵作为样品浓缩器。 泵的反馈回路。 在泵的输出侧具有或不具有中间活塞的储存器。

公开(公告)号：US5597734A

公开(公告)日：1997-01-28

申请号：US503999

申请日：1995-07-19

申请人： Hamish Small ,  John Riviello ,  Christopher A. Pohl

发明人： Hamish Small ,  John Riviello ,  Christopher A. Pohl

IPC分类号： A61B17/60 ,  A61B17/64 ,  G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： An ion chromatography method for analysis of a plurality of analyte ions in a sequence of samples in which ion chromatography is performed on a sample, which is passed to a non-precipitating suppressor ion exchange resin and analyzed, the suppressor being regenerated in one step prior to processing of a subsequent sample.

摘要翻译： 一种用于分析样品序列中的多个分析物离子的离子色谱法，其中对样品进行离子色谱，所述样品被传递到非沉淀抑制离子交换树脂，并分析了在一个步骤中再生的抑制剂 以处理随后的样品。

公开(公告)号：US06316271B1

公开(公告)日：2001-11-13

申请号：US09470833

申请日：1999-12-23

申请人： Hamish Small ,  Nebojsa Avdalovic ,  Yan Liu

发明人： Hamish Small ,  Nebojsa Avdalovic ,  Yan Liu

IPC分类号： G01N3116

CPC分类号： B01J39/26 ,  B01J47/08 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/407 ,  G01N2030/965 ,  Y10T436/117497 ,  B01D15/362

摘要： A method for generating high purity acid or base in an aqueous stream for use in analysis. For generating a base for anion chromatography, the aqueous stream is directed through a cation exchange bed having strongly acid first and weakly acidic second portions. An electrical potential is applied to the bed. Cations on the bed electromigrate into the aqueous stream while hydroxide ions are electrolytically generated to form a base-containing eluent. Analytes to be detected and the generated eluent flow through a detector.

摘要翻译： 一种在含水流中产生高纯度酸或碱的方法，用于分析。 为了产生用于阴离子色谱法的碱，水流通过具有强酸性第一和弱酸性第二部分的阳离子交换床。 电位施加到床上。 床上的阳离子电迁移到水流中，同时电解产生氢氧根离子以形成含碱的洗脱液。 待检测的分析物和产生的洗脱液流过检测器。

公开(公告)号：US08367423B2

公开(公告)日：2013-02-05

申请号：US12706944

申请日：2010-02-17

申请人： Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

发明人： Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

IPC分类号： G01N30/28

CPC分类号： G01N30/96 ,  C25B1/16 ,  C25B1/22 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/965 ,  Y10T436/25 ,  B01D15/36 ,  B01D15/426

摘要： Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.

摘要翻译： 用于产生酸或碱的方法和设备，例如， 用于阴离子的色谱分析。 为了产生碱，该方法包括以下步骤：在阳离子源储存器中提供阳离子源，使水性液体流通过基本上防止液体流动的屏障（例如带电膜）与阳离子源储存器分离的碱性产生室流动， 提供阳离子输送桥，在基底产生室中的阳极阳离子源储存器和阴极之间施加电位以在其中电解产生氢氧根离子，并使阳离子源储存器中的阳离子电迁移并穿过屏障向着 阴极与所运送的阳离子结合以形成阳离子氢氧化物，并且以水溶液流中的阳离子氢氧化物作为来自第一碱基产生室的流出物除去。 合适的阳离子源包括盐溶液，阳离子氢氧化物溶液或阳离子交换树脂。

公开(公告)号：US06682701B1

公开(公告)日：2004-01-27

申请号：US09612074

申请日：2000-07-07

申请人： Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

发明人： Yan Liu ,  Hamish Small ,  Nebojsa Avdalovic

IPC分类号： G01N3002

CPC分类号： G01N30/96 ,  C25B1/16 ,  C25B1/22 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/965 ,  Y10T436/25 ,  B01D15/36 ,  B01D15/426

摘要： Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.

摘要翻译： 用于产生酸或碱的方法和设备，例如， 用于阴离子的色谱分析。 为了产生碱，该方法包括以下步骤：在阳离子源储存器中提供阳离子源，使水性液体流通过基本上防止液体流动的屏障（例如带电膜）与阳离子源储存器分离的碱性产生室流动， 提供阳离子输送桥，在基底产生室中的阳极阳离子源储存器和阴极之间施加电位以在其中电解产生氢氧根离子，并使阳离子源储存器中的阳离子电迁移并穿过屏障向着 阴极与所运送的阳离子结合以形成阳离子氢氧化物，并且以水溶液流中的阳离子氢氧化物作为来自第一碱基产生室的流出物除去。 合适的阳离子源包括盐溶液，阳离子氢氧化物溶液或阳离子交换树脂。