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    2,3,4-substituted cyclopentanones as therapeutic agents
    4.
    发明授权
    2,3,4-substituted cyclopentanones as therapeutic agents 有权
    2,3,4-取代环戊酮作为治疗剂

    公开(公告)号：US07101906B2

    公开(公告)日：2006-09-05

    申请号：US10991284

    申请日：2004-11-16

    申请人： Yariv Donde ,  Robert M. Burk ,  Michael E. Garst ,  Jeremiah H. Nguyen

    发明人： Yariv Donde ,  Robert M. Burk ,  Michael E. Garst ,  Jeremiah H. Nguyen

    IPC分类号： A61K31/881 ,  C07D333/56 ,  C07D333/62

    CPC分类号： C07D333/62 ,  C07C405/0025 ,  C07D333/56

    摘要： Disclosed herein are compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, wherein a dashed line represents the presence or absence of a bond; Y is a carboxylic acid, sulfonic acid, or phosphonic acid functional group; or an amide or ester thereof comprising from 0 to 12 carbon atoms; or Y is hydroxymethyl or an ether thereof comprising from 0 to 12 carbon atoms; or Y is a tetrazolyl functional group; A is —(CH2)6—, cis —CH2—CH═CH—(CH2)3—, or —CH2—C≡C—(CH2)3— wherein 1 or 2 carbons may be substituted with S or O; B is hydrogen, C1-6 hydrocarbyl, CN, CO2H, or —(CH2)mX(CH2)pH, wherein m is at least 1 and the sum of m and p is from 1 to 5; X is S or O; J is H, CH3, or CF3; D is a covalent bond, CH2, O, or S; and E is an aromatic heterobicyclic ring system which may have substituents comprising up to 6 non-hydrogen atoms each. Methods, compositions, and medicaments related thereto are also disclosed.

    摘要翻译： 本文公开了包含其药学上可接受的盐或其前药的化合物，其中虚线表示存在或不存在键; Y是羧酸，磺酸或膦酸官能团; 或其包含0至12个碳原子的酰胺或酯; 或Y是含有0至12个碳原子的羟甲基或其醚; 或Y为四唑基官能团; A是 - （CH 2 CH 2）6 - ，顺式-CH 2 -CH-CH-（CH 2 CH 2） ）3 - 或 - CH 2-C≡C-（CH 2）3 - 其中1或 2个碳可以被S或O取代; B是氢，C 1-6烃基，CN，CO 2 H或 - （CH 2 CH 2）m H 其中m至少为1，m和p之和为1至5; X是S或O; J是H，CH 3或CF 3; D是共价键，CH 2，O或S; 并且E是芳族杂双环系统，其可以具有各自包含多达6个非氢原子的取代基。 还公开了与之相关的方法，组合物和药物。