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公开(公告)号:US07247444B2
公开(公告)日:2007-07-24
申请号:US10409405
申请日:2003-04-08
IPC分类号: G01N33/574
CPC分类号: A61K33/24 , A61K31/196 , A61K31/407 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K38/14 , A61K38/164 , A61K38/168 , A61K38/20 , A61K41/00 , A61K45/06 , A61K47/642 , A61K2300/00
摘要: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
摘要翻译: 本发明涉及IL-19多肽分子的抗癌活性。 IL-19是涉及炎症过程和人类疾病的细胞因子。 本发明包括使用IL-19降低子宫颈癌细胞的增殖,治疗子宫颈癌以及公开的其它用途。 IL-19多肽可以单独施用,或可以与细胞毒素部分融合,并且可以与辐射或化学治疗剂一起施用。
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公开(公告)号:US08486382B2
公开(公告)日:2013-07-16
申请号:US12538029
申请日:2009-08-07
IPC分类号: A61K38/20
CPC分类号: A61K38/20 , A61B18/02 , A61B18/12 , A61B18/20 , A61K38/14 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要: Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.
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公开(公告)号:US20090311215A1
公开(公告)日:2009-12-17
申请号:US12538029
申请日:2009-08-07
CPC分类号: A61K38/20 , A61B18/02 , A61B18/12 , A61B18/20 , A61K38/14 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要: Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.
摘要翻译: 使用白介素-20治疗子宫颈癌或感染人乳头状瘤病毒的细胞。 IL-20可单独施用或与辐射或化学治疗剂联合施用或手术切除所涉及的细胞或病变。
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公开(公告)号:US07074575B2
公开(公告)日:2006-07-11
申请号:US10408991
申请日:2003-04-08
IPC分类号: G01N33/53 , G01N33/567
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4745 , A61K31/53 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K38/164 , A61K38/168 , A61K38/20 , A61K41/00 , A61K47/642 , A61K2300/00
摘要: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
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公开(公告)号:US07323164B2
公开(公告)日:2008-01-29
申请号:US10410447
申请日:2003-04-08
CPC分类号: A61K31/7048 , A61K31/337 , A61K31/4745 , A61K31/555 , A61K31/675 , A61K31/704 , A61K38/14 , A61K38/164 , A61K38/168 , A61K38/20 , A61K41/0038 , A61K47/642 , A61K2300/00
摘要: The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-24 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-24 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
摘要翻译: 本发明涉及IL-24多肽分子的抗癌活性。 IL-24是涉及炎症过程和人类疾病的细胞因子。 本发明包括使用IL-24降低卵巢癌细胞的增殖,治疗卵巢癌以及所公开的其它用途。 IL-24多肽可以单独施用,或可以与细胞毒素部分融合,并且可以与辐射或化学治疗剂一起施用。
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公开(公告)号:US07582287B2
公开(公告)日:2009-09-01
申请号:US10321163
申请日:2002-12-17
IPC分类号: A61K38/19
CPC分类号: A61K38/20 , A61B18/02 , A61B18/12 , A61B18/20 , A61K38/14 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要: Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.
摘要翻译: 使用白介素-20治疗子宫颈癌或感染人乳头状瘤病毒的细胞。 IL-20可单独施用或与辐射或化学治疗剂联合施用或手术切除所涉及的细胞或病变。
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公开(公告)号:US08124088B2
公开(公告)日:2012-02-28
申请号:US12423699
申请日:2009-04-14
申请人: Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
发明人: Wenfeng Xu , Wayne R. Kindsvogel , Yasmin A. Chandrasekher , Stacey R. Dillon , Joyce M. Lehner , Anthony W. Siadak , Pallavur V. Sivakumar , Margaret Dow Moore
IPC分类号: A61K39/395
CPC分类号: C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
摘要翻译: 本发明涉及阻断,抑制,降低,拮抗或中和IL-22,IL-20或IL-20和IL-22多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 IL-22RA(zcytor11)是IL-20和IL-22的常见受体。 本发明包括抗IL-22RA抗体和结合配偶体,以及使用这种抗体和结合配偶体拮抗IL-22或IL-20和IL-22两者的方法。
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公开(公告)号:US07718172B2
公开(公告)日:2010-05-18
申请号:US11829765
申请日:2007-07-27
IPC分类号: A61K39/395 , C07K14/54 , C07K16/00 , C07K16/22
CPC分类号: C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/34
摘要: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
摘要翻译: 本发明涉及阻断IL-TIF多肽分子的活性。 IL-TIF是涉及炎症过程和人类疾病的细胞因子。 本发明包括抗IL-TIF抗体和结合配偶体,以及在IL-TIF相关的人类炎性疾病中使用这样的抗体和结合伴侣拮抗IL-TIF的方法,以及其它用途。
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公开(公告)号:US20090226426A1
公开(公告)日:2009-09-10
申请号:US12433784
申请日:2009-04-30
IPC分类号: A61K39/395 , A61P17/06
CPC分类号: C07K16/244 , A61K31/07 , A61K31/20 , A61K31/203 , A61K31/366 , A61K31/519 , A61K31/525 , A61K31/573 , A61K31/59 , A61K38/13 , A61K39/395 , A61K39/3955 , A61K45/06 , C07K14/7155 , C07K16/2887 , C07K2319/00 , C07K2319/30 , Y10S514/886 , A61K2300/00
摘要: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
摘要翻译: 一种治疗IL-20诱导炎症的方法。 施用IL-20拮抗剂以治疗炎症和相关疾病。 拮抗剂可以是结合IL-20或其受体或与IL-20结合的可溶性受体的抗体。 这些疾病的例子包括成人呼吸系统疾病,牛皮癣,湿疹,接触性皮炎,特应性皮炎,脓毒性休克,多器官衰竭,炎性肺损伤,细菌性肺炎,炎性肠病,类风湿性关节炎,哮喘,溃疡性结肠炎和克罗恩病。
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公开(公告)号:US20090022723A1
公开(公告)日:2009-01-22
申请号:US11829765
申请日:2007-07-27
IPC分类号: A61K39/395 , C12N5/06 , A61P29/00
CPC分类号: C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/34
摘要: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
摘要翻译: 本发明涉及阻断IL-TIF多肽分子的活性。 IL-TIF是涉及炎症过程和人类疾病的细胞因子。 本发明包括抗IL-TIF抗体和结合配偶体,以及在IL-TIF相关的人类炎性疾病中使用这样的抗体和结合伴侣拮抗IL-TIF的方法,以及其它用途。
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