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公开(公告)号：US20070173451A1
公开(公告)日：2007-07-26
申请号：US11690915
申请日：2007-03-26
IPC分类号： A61K38/17
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US20060269551A1
公开(公告)日：2006-11-30
申请号：US11458666
申请日：2006-07-19
申请人： Penny Thompson , Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Hal Blumberg , Maribeth Eagan , Stephen Jaspers , Yasmin Chandrasekher , Julia Novak
发明人： Penny Thompson , Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Hal Blumberg , Maribeth Eagan , Stephen Jaspers , Yasmin Chandrasekher , Julia Novak
IPC分类号： A61K39/395 , A61K38/13 , A61K31/59 , A61K31/573 , A61K31/366 , A61K31/525 , A61K31/20 , A61K31/07 , A61K31/203
CPC分类号： C07K16/244 , A61K31/07 , A61K31/20 , A61K31/203 , A61K31/366 , A61K31/519 , A61K31/525 , A61K31/573 , A61K31/59 , A61K38/13 , A61K39/395 , A61K39/3955 , A61K45/06 , C07K14/7155 , C07K16/2887 , C07K2319/00 , C07K2319/30 , Y10S514/886 , A61K2300/00
摘要： A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
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公开(公告)号：US20060263850A1
公开(公告)日：2006-11-23
申请号：US11458360
申请日：2006-07-18
申请人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
发明人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
IPC分类号： C07K14/715 , C12P21/06
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
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公开(公告)号：US20050003475A1
公开(公告)日：2005-01-06
申请号：US09745792
申请日：2000-12-22
申请人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
发明人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
IPC分类号： A61K38/00 , C07K14/715 , A61K38/17 , C07H21/04
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US20060263851A1
公开(公告)日：2006-11-23
申请号：US11458367
申请日：2006-07-18
申请人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
发明人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
IPC分类号： C12P21/06 , C07K14/715
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
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公开(公告)号：US20070099269A1
公开(公告)日：2007-05-03
申请号：US11549772
申请日：2006-10-16
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070098683A1
公开(公告)日：2007-05-03
申请号：US11551139
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： A61K38/19 , A61K38/20 , A61K39/395
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070048259A1
公开(公告)日：2007-03-01
申请号：US11551356
申请日：2006-10-20
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US20070066807A1
公开(公告)日：2007-03-22
申请号：US11551368
申请日：2006-10-20
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： C07K14/52
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070054320A1
公开(公告)日：2007-03-08
申请号：US11551144
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： G01N33/53
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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