-
公开(公告)号：US20070269407A1
公开(公告)日：2007-11-22
申请号：US11765289
申请日：2007-06-19
IPC分类号： A61K45/00
CPC分类号： A61K33/24 , A61K31/196 , A61K31/407 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K38/14 , A61K38/164 , A61K38/168 , A61K38/20 , A61K41/00 , A61K45/06 , A61K47/642 , A61K2300/00
摘要： The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
摘要翻译： 本发明涉及IL-19多肽分子的抗癌活性。 IL-19是涉及炎症过程和人类疾病的细胞因子。 本发明包括使用IL-19降低子宫颈癌细胞的增殖，治疗子宫颈癌以及公开的其它用途。 IL-19多肽可以单独施用，或可以与细胞毒素部分融合，并且可以与辐射或化学治疗剂一起施用。
-
2.发明申请Anti-IL-20 antibodies and binding partners and methods of using in inflammation 审中-公开抗IL-20抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US20060134756A1
公开(公告)日：2006-06-22
申请号：US10807997
申请日：2004-03-24
申请人： Wenfeng Xu , Wayne Kindsvogel , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
发明人： Wenfeng Xu , Wayne Kindsvogel , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-20多肽分子的活性。 IL-20和IL-22是涉及炎症过程和人类疾病的细胞因子。 本发明包括抗IL-20和抗IL-22RA抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。
-
公开(公告)号：US20060141582A1
公开(公告)日：2006-06-29
申请号：US11256499
申请日：2005-10-21
申请人： Wenfeng Xu , Wayne Kindsvogel , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
发明人： Wenfeng Xu , Wayne Kindsvogel , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
IPC分类号： C12P21/04
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
-
4.发明申请Anti-IL-20 receptor antibodies and binding partners and methods of using in inflammation 审中-公开抗IL-20受体抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US20050170468A1
公开(公告)日：2005-08-04
申请号：US10994151
申请日：2004-11-19
申请人： Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
发明人： Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 receptor polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 receptor antibodies and binding partners, including anti-IL-20RA, anti-IL-20RB and anti-IL-20RA/IL-20RB antibodies as well as methods for antagonizing IL-20RA and IL-20RB, either individually or together, using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断IL-20受体多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。 本发明包括抗IL-20受体抗体和结合配偶体，包括抗IL-20RA，抗IL-20RB和抗IL-20RA / IL-20RB抗体以及拮抗IL-20RA和IL- 20RB，单独或一起使用这种抗体和结合配偶体。
-
5.发明申请Anti-IL-20 antibodies and binding partners and methods of using in inflammation 有权抗IL-20抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US20050136004A1
公开(公告)日：2005-06-23
申请号：US10994116
申请日：2004-11-19
申请人： Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
发明人： Wenfeng Xu , Wayne Kindsvogel , Zhi Chen , Steven Hughes , Yasmin Chandrasekher , Stacey Dillon , Joyce Lehner , Anthony Siadak , Pallavur Sivakumar , Margaret Moore
IPC分类号： A61K38/00 , A61K38/20 , C07K14/54 , C07K14/715 , C07K16/24 , C07K16/28 , C12P21/04 , A61K51/00 , A61K39/395
CPC分类号： C07K16/2866 , A61K38/1793 , A61K38/20 , A61K47/60 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
摘要翻译： 本发明涉及阻断IL-20多肽分子的活性。 IL-20是涉及炎症过程和人类疾病的细胞因子。 IL-20RA / IL-20RB是IL-20的常见受体。 本发明包括抗IL-20抗体和结合配偶体，以及使用这种抗体和结合配偶体拮抗IL-20的方法。
-
公开(公告)号：US20080033148A1
公开(公告)日：2008-02-07
申请号：US11829755
申请日：2007-07-27
CPC分类号： C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/34
摘要： The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
摘要翻译： 本发明涉及阻断IL-TIF多肽分子的活性。 IL-TIF是涉及炎症过程和人类疾病的细胞因子。 本发明包括抗IL-TIF抗体和结合配偶体，以及在IL-TIF相关的人类炎性疾病中使用这样的抗体和结合伴侣拮抗IL-TIF的方法，以及其它用途。
-
公开(公告)号：US20070173451A1
公开(公告)日：2007-07-26
申请号：US11690915
申请日：2007-03-26
IPC分类号： A61K38/17
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
-
公开(公告)号：US20060269551A1
公开(公告)日：2006-11-30
申请号：US11458666
申请日：2006-07-19
申请人： Penny Thompson , Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Hal Blumberg , Maribeth Eagan , Stephen Jaspers , Yasmin Chandrasekher , Julia Novak
发明人： Penny Thompson , Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Hal Blumberg , Maribeth Eagan , Stephen Jaspers , Yasmin Chandrasekher , Julia Novak
IPC分类号： A61K39/395 , A61K38/13 , A61K31/59 , A61K31/573 , A61K31/366 , A61K31/525 , A61K31/20 , A61K31/07 , A61K31/203
CPC分类号： C07K16/244 , A61K31/07 , A61K31/20 , A61K31/203 , A61K31/366 , A61K31/519 , A61K31/525 , A61K31/573 , A61K31/59 , A61K38/13 , A61K39/395 , A61K39/3955 , A61K45/06 , C07K14/7155 , C07K16/2887 , C07K2319/00 , C07K2319/30 , Y10S514/886 , A61K2300/00
摘要： A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.034 秒)
