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公开(公告)号：US20060269551A1
公开(公告)日：2006-11-30
申请号：US11458666
申请日：2006-07-19
申请人： Penny Thompson , Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Hal Blumberg , Maribeth Eagan , Stephen Jaspers , Yasmin Chandrasekher , Julia Novak
发明人： Penny Thompson , Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Hal Blumberg , Maribeth Eagan , Stephen Jaspers , Yasmin Chandrasekher , Julia Novak
IPC分类号： A61K39/395 , A61K38/13 , A61K31/59 , A61K31/573 , A61K31/366 , A61K31/525 , A61K31/20 , A61K31/07 , A61K31/203
CPC分类号： C07K16/244 , A61K31/07 , A61K31/20 , A61K31/203 , A61K31/366 , A61K31/519 , A61K31/525 , A61K31/573 , A61K31/59 , A61K38/13 , A61K39/395 , A61K39/3955 , A61K45/06 , C07K14/7155 , C07K16/2887 , C07K2319/00 , C07K2319/30 , Y10S514/886 , A61K2300/00
摘要： A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
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公开(公告)号：US20070173451A1
公开(公告)日：2007-07-26
申请号：US11690915
申请日：2007-03-26
IPC分类号： A61K38/17
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US20070065403A1
公开(公告)日：2007-03-22
申请号：US11548810
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/20
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070087414A1
公开(公告)日：2007-04-19
申请号：US11548826
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070078259A1
公开(公告)日：2007-04-05
申请号：US11548830
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： C07K14/715
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070065405A1
公开(公告)日：2007-03-22
申请号：US11548824
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/54
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
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公开(公告)号：US20070049526A1
公开(公告)日：2007-03-01
申请号：US11548805
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/17
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20070065404A1
公开(公告)日：2007-03-22
申请号：US11548819
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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公开(公告)号：US20070048258A1
公开(公告)日：2007-03-01
申请号：US11548814
申请日：2006-10-12
申请人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
发明人： Penny Thompson , Katherine Lewis , Stephen Jaspers , Richard Garcia , Robert West , Susan Holderman , Chung Chan , Paul Sheppard , Anitra Wolf
IPC分类号： A61K38/19
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/47 , C07K14/4702 , G01N2800/06 , G01N2800/065
摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.
摘要翻译： 本发明提供使用Zven1和Zven2多肽来增加趋化因子产生的方法。 本发明还提供了用Zven1和Zven2多肽治疗肠蠕动障碍和改善胃肠功能的方法。
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10.发明申请Soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners and methods of using in inflammation 审中-公开可溶性ZcytoR21，抗ZcytoR21抗体和结合配偶体以及在炎症中使用的方法公开(公告)号：US20060142192A1
公开(公告)日：2006-06-29
申请号：US11253200
申请日：2005-10-18
申请人： Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
发明人： Zeren Gao , Rolf Kuestner , Mark Appleby , Katherine Lewis , Patricia McKernan , Shannon Okada , David Taft , Joseph Kuijper , Stephen Jaspers , Steven Levin
IPC分类号： A61K38/17 , C07K14/715
CPC分类号： C07K14/7155 , A61K38/00 , A61K39/395 , A61K47/50 , A61K47/60 , C07K14/54 , C07K16/00
摘要： The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
摘要翻译： 本发明涉及可用于阻断，抑制，降低，拮抗或中和IL-17C活性的ZcytoR21拮抗剂，例如可溶性受体和抗ZcytoR21抗体。 IL-17C是涉及炎症过程和人类疾病的细胞因子。 ZcytoR21是IL-17C的受体。 本发明包括可溶性ZcytoR21，抗ZcytoR21抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17C的方法。
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