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公开(公告)号：US20140023695A1
公开(公告)日：2014-01-23
申请号：US13983166
申请日：2012-02-01
申请人： Yasuaki Okada , Katsuhiro OKada , Masato Nishimura , Yuji Kawaharada , Hiroo Maeda , Kazumitsu Yamamoto , Masayasu Tanaka
发明人： Yasuaki Okada , Katsuhiro OKada , Masato Nishimura , Yuji Kawaharada , Hiroo Maeda , Kazumitsu Yamamoto , Masayasu Tanaka
IPC分类号： A61K31/496 , A61K9/70
CPC分类号： A61K31/496 , A61K9/7061
摘要： A patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein the adhesive layer contains 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine or a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid, sesame oil and one or more kinds of stabilizers selected from 2-mercaptobenzimidazole, 2,6-di-tert-butyl-4-methylphenol and propyl gallate.A patch preparation containing a support and an adhesive layer containing lactic acid and magnesium aluminometasilicate and formed on at least one surface of the support, which preparation is superior in both skin permeability and adhesiveness in the presence of water.
摘要翻译： 一种贴剂，其包含支撑体和形成在支持体的一个表面上的粘合剂层，其中粘合剂层含有2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7,8 ，9,10-六氢环辛[b]吡啶或其生理上可接受的酸加成盐，丙烯酸聚合物，乳酸，芝麻油和一种或多种选自2-巯基苯并咪唑，2,6-二叔丁基 -4-甲基苯酚和没食子酸丙酯。 一种贴剂，其含有载体和含有乳酸和硅酸铝镁的粘合剂层，并形成在载体的至少一个表面上，该制剂在水的存在下具有优异的皮肤渗透性和粘合性。
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公开(公告)号：US09138419B2
公开(公告)日：2015-09-22
申请号：US13983134
申请日：2012-02-01
IPC分类号： A61K9/70 , A61K31/167 , A61K31/4453 , A61K31/496
CPC分类号： A61K9/7038 , A61K9/7061 , A61K31/167 , A61K31/4453 , A61K31/496
摘要： The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water.A patch preparation containing a support and an adhesive layer on one surface of the support, wherein the adhesive layer contains a drug excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid and magnesium aluminometasilicate.
摘要翻译： 本发明的问题在于提供含有药物（不含2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7,8,9,10-六氢环辛酸 [b]吡啶及其生理上可接受的酸加成盐），其在药物的皮肤渗透性方面都优异，并且在水存在下的粘合性。 在载体的一个表面上含有载体和粘合剂层的贴片制剂，其中所述粘合剂层含有除2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7 ，8,9,10-六氢环辛基[b]吡啶及其生理上可接受的酸加成盐，丙烯酸聚合物，乳酸和硅酸铝镁。
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公开(公告)号：US20130315976A1
公开(公告)日：2013-11-28
申请号：US13983134
申请日：2012-02-01
IPC分类号： A61K9/70
CPC分类号： A61K9/7038 , A61K9/7061 , A61K31/167 , A61K31/4453 , A61K31/496
摘要： The problem of the present invention is to provide a patch preparation containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), which is superior in both the skin permeability of a drug, and adhesiveness in the presence of water.A patch preparation containing a support and an adhesive layer on one surface of the support, wherein the adhesive layer contains a drug excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof, an acrylic polymer, lactic acid and magnesium aluminometasilicate.
摘要翻译： 本发明的问题在于提供含有药物（不含2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7,8,9,10-六氢环辛酸 [b]吡啶及其生理上可接受的酸加成盐），其在药物的皮肤渗透性方面都优异，并且在水存在下的粘合性。 在载体的一个表面上含有载体和粘合剂层的贴片制剂，其中所述粘合剂层含有除2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7 ，8,9,10-六氢环辛基[b]吡啶及其生理上可接受的酸加成盐，丙烯酸聚合物，乳酸和硅酸铝镁。
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公开(公告)号：US20130302514A1
公开(公告)日：2013-11-14
申请号：US13983131
申请日：2012-02-01
IPC分类号： A61K9/70
CPC分类号： A61K9/7023 , A61K9/7061 , A61K31/00 , A61K47/12
摘要： The problem of the present invention is to minimize the influence of lactic acid on the property of an adhesive layer, and provide a production method of a patch preparation, which is capable of affording a patch preparation superior in the property of an adhesive layer.A method of producing a patch preparation comprising (a): a step of forming an adhesive layer containing a drug (excluding 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine and a physiologically acceptable acid addition salt thereof), an acrylic polymer and an organic liquid component compatible with the acrylic polymer, but without containing lactic acid, and (b): a step of adding lactic acid to the aforementioned adhesive layer.
摘要翻译： 本发明的问题是使乳酸对粘合剂层的性能的影响最小化，并且提供能够提供粘合剂层性能优异的贴剂的贴剂的制备方法。 一种制备贴剂的方法，包括（a）：形成含有药物的粘合剂层（不包括2-（4-乙基-1-哌嗪基）-4-（4-氟苯基）-5,6,7， 8,9,10-六氢环辛[b]吡啶及其生理上可接受的酸加成盐），丙烯酸类聚合物和与丙烯酸类聚合物相容但不含乳酸的有机液体成分，（b）：添加 乳酸到上述粘合剂层。
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公开(公告)号：US09808609B2
公开(公告)日：2017-11-07
申请号：US13983510
申请日：2012-02-01
IPC分类号： A61M35/00 , A61L31/12 , A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
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公开(公告)号：US09351942B2
公开(公告)日：2016-05-31
申请号：US13983481
申请日：2012-02-01
IPC分类号： A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译： 本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。 该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁 硅酸铝 在贴片制剂中，上述粘合剂层还含有药物。
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公开(公告)号：US20130315978A1
公开(公告)日：2013-11-28
申请号：US13983481
申请日：2012-02-01
IPC分类号： A61K9/70 , A61K31/663 , A61K31/405
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译： 本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。 该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁 硅酸铝 在贴片制剂中，上述粘合剂层还含有药物。
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公开(公告)号：US20130310777A1
公开(公告)日：2013-11-21
申请号：US13983510
申请日：2012-02-01
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译： 本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。 该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为500,000-1,600,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁 硅酸铝 在贴片制剂中，上述粘合剂层还含有药物。
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9.发明授权Film having low refractive index film and method for producing the same, anti-reflection film and method for producing the same, coating liquid set for low refractive index film, substrate having microparticle-laminated thin film and method for producing the same, and optical member 有权具有低折射率膜的膜及其制造方法，防反射膜及其制造方法，低折射率膜用涂布液，具有微粒层叠薄膜的基板及其制造方法以及光学部件公开(公告)号：US09188708B2
公开(公告)日：2015-11-17
申请号：US12998363
申请日：2009-10-13
IPC分类号： B05D5/06 , G02B1/118 , B29D11/00 , C09D5/00 , C09D7/12 , G02B1/113 , G02B5/02 , C08K3/22 , C08K7/26
CPC分类号： G02B1/118 , B29D11/00865 , C08K3/22 , C08K7/26 , C09D5/006 , C09D7/61 , C09D7/67 , G02B1/113 , G02B1/115 , G02B5/0242 , G02B5/0268 , G02B5/0278 , G02B5/0294 , G02B2207/107 , G02B2207/109 , Y10T428/24893
摘要： Provided is a film having a low refractive index, which can be formed under normal temperature and pressure while obtaining a lower refractive index, has excellent adhesion with a solid substrate, and does not lose geometric optical properties, such as the diffusibility or light-harvesting capability attributed to the microstructure. Also disclosed is a method for producing the same. The film having a low refractive index is obtained by causing an electrolyte polymer and microparticles to be alternately adsorbed on the surface of a solid substrate and bringing the resulting microparticle-laminated film into contact with a silicon compound solution in order to bond the solid substrate with microparticles and microparticles with microparticles. The silicon compound solution is selected from (1) the hydrolysis product of alkoxysilane (I) wherein the functional groups are formed from hydrolyzable groups and non-hydrolyzable organic groups, and the condensation reaction product thereof, (2) the hydrolysis product of a mixture of alkoxysilane (I) and alkoxysilane (II) wherein the functional groups are formed from hydrolyzable groups alone, and the condensation reaction product thereof; and (3) a mixture of hydrolysis product and condensation product thereof according to (1) and alkoxysilane (II).
摘要翻译： 提供一种具有低折射率的膜，其可以在常温和压力下形成，同时获得较低的折射率，与固体基材具有优异的粘附性，并且不会失去几何光学性质，例如扩散性或光收集 归因于微结构的能力。 还公开了其制造方法。 通过使电解质聚合物和微粒交替吸附在固体基材的表面上并使得到的微粒层叠膜与硅化合物溶液接触以使固体基材与 具有微粒的微粒和微粒。 硅化合物溶液选自（1）其中官能团由可水解基团和不可水解的有机基团形成的烷氧基硅烷（I）的水解产物及其缩合反应产物，（2）混合物的水解产物 的烷氧基硅烷（I）和烷氧基硅烷（II），其中官能团由可水解基团单独形成，及其缩合反应产物; 和（3）根据（1）的水解产物及其缩合产物和烷氧基硅烷（II）的混合物。
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公开(公告)号：US08309119B2
公开(公告)日：2012-11-13
申请号：US12071867
申请日：2008-02-27
IPC分类号： A61K9/70 , A61K31/4468 , A61F13/02
CPC分类号： A61L24/0015 , A61L15/58 , A61L24/04 , A61L2300/402
摘要： The present invention aims at providing an adhesive preparation wherein a drug is sufficiently dissolved in an adhesive layer and is not easily separated from the adhesive layer even during preservation of the adhesive preparation.The present invention provides an adhesive preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer comprises a first synthetic rubber having a viscosity average molecular weight of 1,600,000-6,500,000, a drug, an organic liquid component and a tackifier. The present invention further provides the aforementioned adhesive preparation, wherein the organic liquid component is contained in the adhesive layer in a proportion of 20 wt % or above relative to the total weight of the adhesive layer.
摘要翻译： 本发明的目的在于提供一种粘合剂制剂，其中药物在粘合剂层中充分溶解，并且即使在粘合剂制备过程中也不容易与粘合层分离。 本发明提供一种在支撑体的至少一个表面上具有粘合剂层的粘合剂制剂，其中粘合剂层包括粘均分子量为1,600,000-6,500,000的第一合成橡胶，药物，有机液体组分和增粘剂 。 本发明还提供了上述粘合剂制剂，其中粘合剂层中的有机液体组分相对于粘合剂层的总重量为20重量％以上。
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