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公开(公告)号：US20050158719A1
公开(公告)日：2005-07-21
申请号：US10476985
申请日：2002-04-26
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： A61K38/00 , A61P9/00 , A61P15/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/705 , G01N33/574
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12N2799/026 , C12Q2600/158
摘要： A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided. The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.
摘要翻译： 提供新生血管形成，血管疾病，炎性疾病，新生血管新生血管疾病，生殖系统疾病，中枢神经系统疾病和癌症的标志物，检测标志物的方法和疾病的诊断试剂盒。 此外，提供了疾病的治疗剂。 KIAA1036在卵巢癌和大肠癌中的表达增强，KIAA1036在脐静脉内皮细胞中表达，抑制细胞中的DNA合成，细胞迁移和管腔形成。 因此，KIAA1036可用作新生血管形成，血管疾病，炎性疾病，新生血管新生，生殖系统疾病，中枢神经系统疾病或癌症的标志物。 另外，KIAA1036可用于筛选激动剂，拮抗剂，DNA合成抑制剂，细胞迁移抑制剂和新生血管抑制剂。 通过筛选获得的物质，KIAA1036和抗体可用作上述疾病的治疗剂。
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公开(公告)号：US20080213759A1
公开(公告)日：2008-09-04
申请号：US11722799
申请日：2005-12-20
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
CPC分类号： A61K45/06 , A61K31/7088 , A61K38/00 , C07K14/4703 , C07K16/22 , G01N33/574 , G01N2333/515 , G01N2500/04 , Y10T436/143333 , A61K2300/00
摘要： Because AK022567 has angiogenesis inhibitory activity, it is useful as an angiogenesis inhibitor. Furthermore, 4 splicing variants obtained from the same gene are also useful as an angiogenesis inhibitor. These 5 polypeptides, polynucleotides encoding the polypeptides and antibodies against the polypeptides are useful for screening of a candidate compound as an angiogenesis inhibitor or promoter. A compound obtained from the screening is useful as a medicine and can be used for a preventive or therapeutic agent for an angiogenesis related disease.
摘要翻译： 由于AK022567具有血管发生抑制活性，因此可用作血管生成抑制剂。 此外，从相同基因获得的4个剪接变体也可用作血管发生抑制剂。 这5种多肽，编码多肽的多核苷酸和针对多肽的抗体可用于筛选作为血管生成抑制剂或启动子的候选化合物。 从筛选获得的化合物可用作药物，并且可用于血管生成相关疾病的预防或治疗剂。
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公开(公告)号：US08426376B2
公开(公告)日：2013-04-23
申请号：US12702272
申请日：2010-02-08
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： A61K31/7088 , C12Q1/68 , A61P9/10
CPC分类号： A61K45/06 , A61K31/7088 , A61K38/00 , C07K14/4703 , C07K16/22 , G01N33/574 , G01N2333/515 , G01N2500/04 , Y10T436/143333 , A61K2300/00
摘要： Because AK022567 has angiogenesis inhibitory activity, it is useful as an angiogenesis inhibitor. Furthermore, 4 splicing variants obtained from the same gene are also useful as an angiogenesis inhibitor. These 5 polypeptides, polynucleotides encoding the polypeptides and antibodies against the polypeptides are useful for screening of a candidate compound as an angiogenesis inhibitor or promoter. A compound obtained from the screening is useful as a medicine and can be used for a preventive or therapeutic agent for an angiogenesis related disease.
摘要翻译： 由于AK022567具有血管发生抑制活性，因此可用作血管生成抑制剂。 此外，从相同基因获得的4个剪接变体也可用作血管发生抑制剂。 这5种多肽，编码多肽的多核苷酸和针对多肽的抗体可用于筛选作为血管生成抑制剂或启动子的候选化合物。 从筛选获得的化合物可用作药物，并且可用于血管生成相关疾病的预防或治疗剂。
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公开(公告)号：US07956036B2
公开(公告)日：2011-06-07
申请号：US12027873
申请日：2008-02-07
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
IPC分类号： C12N5/00 , A61K38/17 , A61K31/711 , C12Q1/68 , A61P35/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12N2799/026 , C12Q2600/158
摘要： A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided.The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.
摘要翻译： 提供新生血管形成，血管疾病，炎性疾病，新生血管新生血管疾病，生殖系统疾病，中枢神经系统疾病和癌症的标志物，检测标志物的方法和疾病的诊断试剂盒。 此外，提供了疾病的治疗剂。 KIAA1036在卵巢癌和大肠癌中的表达增强，KIAA1036在脐静脉内皮细胞中表达，抑制细胞中的DNA合成，细胞迁移和管腔形成。 因此，KIAA1036可用作新生血管形成，血管疾病，炎性疾病，新生血管新生，生殖系统疾病，中枢神经系统疾病或癌症的标志物。 另外，KIAA1036可用于筛选激动剂，拮抗剂，DNA合成抑制剂，细胞迁移抑制剂和新生血管抑制剂。 通过筛选获得的物质，KIAA1036和抗体可用作上述疾病的治疗剂。
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公开(公告)号：US20090270314A1
公开(公告)日：2009-10-29
申请号：US12088234
申请日：2006-09-27
申请人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi Sato , Hikaru Sonoda , Hideki Ohta
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5011 , G01N33/57496 , G01N2333/475
摘要： The present inventors found out four kinds of fragments (42 kD, 36 kD, 32 kD, 27 kD) by forcibly expressing vasohibin in a vascular endothelial cell. The present inventors analyzed those fragments and, as a result, found out low molecular weight vasohibin which has an anti-angiogenic activity. The low molecular weight vasohibin is useful as a therapeutic agent for various diseases such as a vascular disease associated with angiogenesis, an inflammatory disease, an entoptic neovascular disease, a reproductive disease, a central nervous system disease and cancer and the like. In addition, the low molecular weight vasohibin is also useful as a marker for angiogenesis.
摘要翻译： 本发明人通过在血管内皮细胞中强制表达血管舒缓，发现了四种片段（42kD，36kD，32kD，27kD）。 本发明人分析了这些片段，结果发现具有抗血管生成活性的低分子量血管舒缓素。 低分子量血管舒缓剂可用作各种疾病的治疗剂，例如与血管发生，炎性疾病，内在的新血管病，生殖疾病，中枢神经系统疾病和癌症等有关的血管疾病。 此外，低分子量血管舒张也可用作血管生成的标志物。
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公开(公告)号：US20080269129A1
公开(公告)日：2008-10-30
申请号：US12027873
申请日：2008-02-07
申请人： Yasufumi SATO , Hikaru Sonoda , Hideki Ohta
发明人： Yasufumi SATO , Hikaru Sonoda , Hideki Ohta
IPC分类号： A61K38/17 , C12N5/00 , A61K31/711 , C12Q1/68 , A61P35/00
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C12N2799/026 , C12Q2600/158
摘要： A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided.The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.
摘要翻译： 提供新生血管形成，血管疾病，炎性疾病，新生血管新生血管疾病，生殖系统疾病，中枢神经系统疾病和癌症的标志物，检测标记物的方法和疾病的诊断试剂盒。 此外，提供了疾病的治疗剂。 KIAA1036在卵巢癌和大肠癌中的表达增强，KIAA1036在脐静脉内皮细胞中表达，抑制细胞中的DNA合成，细胞迁移和管腔形成。 因此，KIAA1036可用作新生血管形成，血管疾病，炎性疾病，新生血管新生，生殖系统疾病，中枢神经系统疾病或癌症的标志物。 另外，KIAA1036可用于筛选激动剂，拮抗剂，DNA合成抑制剂，细胞迁移抑制剂和新生血管抑制剂。 通过筛选获得的物质，KIAA1036和抗体可用作上述疾病的治疗剂。
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公开(公告)号：US07371818B2
公开(公告)日：2008-05-13
申请号：US10451417
申请日：2001-12-26
申请人： Satoshi Orita , Rie Hayashi , Hikaru Sonoda , Kazuhiko Maekawa
发明人： Satoshi Orita , Rie Hayashi , Hikaru Sonoda , Kazuhiko Maekawa
IPC分类号： C07K1/00
CPC分类号： G01N33/57484 , A01K2217/05 , A61K38/00 , C07K14/475 , C12Q1/6886 , C12Q2600/158 , G01N33/574
摘要： A novel chordin-like polypeptide is found out in a protein secreted from mesenchymal stem cells. This polypeptide is useful as a cancer marker and a remedy for parotid cancer, lung cancer, esophagus cancer, gastric cancer, duodenal carcinoma, kidney cancer, ureteral cancer, testicular cancer, ovarian cancer, uterine cancer, leukemia, intestinal cancer, colon cancer, rectal cancer, biliary cancer or thyroid cancer cells, etc. Moreover, it is found out that the above polypeptide has an activity of modulating bone differentiation. Thus, this polypeptide is also useful as a bone disease marker and a remedy for bone diseases such as arthritis deformans, rheumatoid arthritis and osteoporosis.
摘要翻译： 在从间充质干细胞分泌的蛋白质中发现了一种新颖的类似脊索样的多肽。 该多肽可用作癌症标志物和腮腺癌，肺癌，食管癌，胃癌，十二指肠癌，肾癌，输尿管癌，睾丸癌，卵巢癌，子宫癌，白血病，肠癌，结肠癌， 直肠癌，胆道癌或甲状腺癌细胞等。此外，发现上述多肽具有调节骨分化的活性。 因此，该多肽也可用作骨疾病标记物和骨疾病如关节炎变形体，类风湿性关节炎和骨质疏松症的治疗方法。
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