公开(公告)号：US06985182B1

公开(公告)日：2006-01-10

申请号：US09717758

申请日：2000-11-21

申请人： Yasuhiro Morinaka ,  Hiroyoshi Komobuchi ,  Takumi Yamaguchi ,  Sei Suzuki

发明人： Yasuhiro Morinaka ,  Hiroyoshi Komobuchi ,  Takumi Yamaguchi ,  Sei Suzuki

IPC分类号： H04N5/335

CPC分类号： H01L27/14806

摘要： In a solid-state imaging device, a plurality of vertical charge transfer paths is arranged at a horizontal pitch A within a photoelectric conversion region, and at a pitch B that is smaller than the pitch A in a portion where the signals are input into the horizontal charger transfer path. A read-out amplifier and a horizontal charge transfer path for receiving signals from vertical charge transfer paths are provided for each photoelectric conversion block into which the photoelectric conversion region has been partitioned. The read-out amplifiers have the same shape and their positional relation is one of parallel displacement in regions that are obtained by changing the pitch of the vertical charge transfer portions. Thus, a solid-state imaging device is achieved that is not so easily influenced by mask misalignments or skewed ion implantation angles, and in which signal read-out at high speeds is possible.

摘要翻译： 在固态成像装置中，在光电转换区域内以水平间距A布置多个垂直电荷传输路径，并且在信号被输入到该部分的部分中以比间距A小的间距B 水平充电器传输路径。 为光电转换区域分割成的每个光电转换块提供读出放大器和用于从垂直电荷传输路径接收信号的水平电荷传输路径。 读出放大器具有相同的形状，并且它们的位置关系是通过改变垂直电荷转移部分的间距而获得的区域中的平行位移之一。 因此，实现了不容易受到掩模未对准或偏斜离子注入角度的影响的固态成像装置，并且其中以高速度读出信号是可能的。

公开(公告)号：US07148926B2

公开(公告)日：2006-12-12

申请号：US10311672

申请日：2002-05-09

申请人： Yasuhiro Morinaka ,  Hiroyoshi Komobuchi ,  Akito Kidera ,  Toshiya Fujii

发明人： Yasuhiro Morinaka ,  Hiroyoshi Komobuchi ,  Akito Kidera ,  Toshiya Fujii

IPC分类号： H04N3/14

CPC分类号： H04N9/045 ,  H04N5/347 ,  H04N5/3728

摘要： A color filter arrangement (11) is used, in which a plurality of filter units are each made of 2×2 arrangements of red (R), green (G), green (G) and blue (B) color elements. First, signal charges are added up for all pixels belonging to each of a plurality of pixel blocks made of quadratic arrangements of 3×3 of pixels, which are larger than the filter units (2×2 arrangement). Then, compressed color information for each of the pixel blocks is obtained from a result of the addition for each pixel block, taking the 2×2 arrangements of pixel blocks as large filter units.

摘要翻译： 使用滤色器装置（11），其中多个滤色器单元分别由红（R），绿（G），绿（G）和蓝（B）色元素的2×2布置构成。 首先，对于属于大于滤波器单元（2x2排列）的3×3像素的二次排列构成的多个像素块中的每一个像素块的所有像素，相加信号电荷。 然后，以每个像素块的加法结果，以像素块的2×2布置为大的滤波器单位，获得每个像素块的压缩颜色信息。

公开(公告)号：US07050099B2

公开(公告)日：2006-05-23

申请号：US10125082

申请日：2002-04-18

申请人： Kentaro Takakura ,  Toshiya Fujii ,  Hiroyoshi Komobuchi ,  Yasuhiro Morinaka ,  Kazuyuki Inokuma

发明人： Kentaro Takakura ,  Toshiya Fujii ,  Hiroyoshi Komobuchi ,  Yasuhiro Morinaka ,  Kazuyuki Inokuma

IPC分类号： H04N5/202

CPC分类号： H04N5/2176 ,  H04N5/3653 ,  H04N5/3728

摘要： Gray level data of boundary pixels that are adjacent to a block boundary in a photoelectric conversion section is stored. Then, a cumulative histogram regarding the number of pixels for different gray levels is produced based on the stored gray level data separately for each block, and a data table representing the correspondence between each gray level before correction and that after correction for the block to be corrected is produced so as to reduce the difference between the cumulative histograms. The data table is stored in a correction data RAM. By using the data table, the outputs of the block to be corrected are non-linearly corrected for different gray levels.

公开(公告)号：US5783564A

公开(公告)日：1998-07-21

申请号：US669219

申请日：1996-06-24

申请人： Haruyuki Chaki ,  Naoko Ando ,  Yasuhiro Morinaka ,  Ken-ichi Saito ,  Tomoko Yugami ,  Rie Yoshida

发明人： Haruyuki Chaki ,  Naoko Ando ,  Yasuhiro Morinaka ,  Ken-ichi Saito ,  Tomoko Yugami ,  Rie Yoshida

IPC分类号： C07J17/00 ,  C07J41/00 ,  A61K31/70 ,  A61K31/58

CPC分类号： C07J41/0005 ,  C07J17/005

摘要： Sialic acid derivatives represented by the general formula (I): wherein R.sup.1 is a steroidal compound residue; R.sup.2 is H or alkyl; R.sup.3 is alkyl; ##STR1## wherein each of R.sup.6 and R.sup.7 is H, alkyl or the like and I is an integer of 0 to 6; or the like; X is O or S; R.sup.4 is H or acyl; and R.sup.5 is R.sup.14 O--(R.sup.14 is H or acyl) or R.sup.15 NH--(R.sup.15 is acyl or the like); their salts, hydrates or solvates are provided. Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.

摘要翻译： 由通式（I）表示的唾液酸衍生物：其中R1是甾族化合物残基; R2是H或烷基; R3是烷基; 其中R6和R7各自为H，烷基等，I为0-6的整数; 或类似物; X是O或S; R4是H或酰基; R5为R14O-（R14为H或酰基）或R15NH-（R15为酰基等）; 提供它们的盐，水合物或溶剂合物。 预期本发明的唾液酸衍生物是预防和治疗老年性痴呆（包括阿尔茨海默氏病等）的有效药物，因为它们增加胆碱能神经元中的ChAT活性。

公开(公告)号：USRE35801E

公开(公告)日：1998-05-19

申请号：US309558

申请日：1994-09-20

申请人： Hiroyoshi Nishi ,  Toshiaki Watanabe ,  Satoshi Yuki ,  Yasuhiro Morinaka ,  Katsuhiko Iseki ,  Hiroko Nakajima (nee Sakurai)

发明人： Hiroyoshi Nishi ,  Toshiaki Watanabe ,  Satoshi Yuki ,  Yasuhiro Morinaka ,  Katsuhiko Iseki ,  Hiroko Nakajima (nee Sakurai)

IPC分类号： C07D231/20 ,  C07D231/22 ,  C07D231/26 ,  C07D231/28 ,  C07D231/56 ,  A61K31/415

CPC分类号： C07D231/56 ,  C07D231/20 ,  C07D231/22 ,  C07D231/26 ,  C07D231/28

摘要： A prophylactic and therapeutic agent for circulatory disorders, comprising a pyrazolone derivative of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom, an aryl group, an alkyl group having 1 to 5 carbon atoms or an alkoxycarbonylalkyl group having a total carbon number of 3 to 6; R.sub.2 represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group having 1 to 5 carbon atoms or hydroxyalkyl group having 1 to 3 carbon atoms or R.sub.1 and R.sub.2 taken together represent an alkylene group having 3 to 5 carbon atoms; R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, a benzyl group, a naphthyl group, or a phenyl group which is unsubstituted or substituted with 1 to 3 substituents which are the same or different selected from the group consisting of alkyl groups having 1 to 5 carbon atoms, alkoxy groups having 1 to 5 carbon atoms, hydroxyalkyl groups having 1 to 3 carbon atoms, alkoxycarbonyl groups having total carbon number of 2 to 5, alkylmercapto groups having 1 to 3 carbon atoms, alkylamino groups having 1 to 4 carbon atoms, dialkylamino groups having total carbon number of 2 to 8, halogen atoms, trifluoromethyl group, carboxyl group, cyano group, hydroxyl group, nitro group, amino group and acetamide group, or a pharmaceutically acceptable salt thereof as an active ingredient. The agent of the present invention is useful as a prophylactic and therapeutic agent for circulatory disorders, particularly as an inhibitor against lipid peroxidation and/or an agent for normalizing cerebral dysfunctions.

摘要翻译： 一种循环系统疾病的预防和治疗剂，其包含下式的吡唑啉酮衍生物：其中R 1表示氢原子，芳基，具有1至5个碳原子的烷基或具有总碳数的烷氧基羰基烷基 3至6; R 2表示氢原子，芳氧基，芳基巯基，碳原子数1〜5的烷基或碳原子数1〜3的羟烷基，或者R 1和R 2一起表示碳原子数3〜5的亚烷基。 R3表示氢原子，碳原子数1〜5的烷基，碳原子数5〜7的环烷基，碳原子数1〜3的羟烷基，苄基，萘基或苯基， 未取代或被1〜3个选自碳原子数1〜5的烷基，碳原子数为1〜5的烷氧基，碳原子数1〜3的烷氧基，碳原子数1〜3的烷氧基，烷氧基羰基， 总碳数为2至5，具有1至3个碳原子的烷基巯基，具有1至4个碳原子的烷基氨基，总碳数为2至8的二烷基氨基，卤素原子，三氟甲基，羧基，氰基，羟基 基团，硝基，氨基和乙酰胺基，或其药学上可接受的盐作为活性成分。 本发明的药剂可用作循环障碍的预防和治疗剂，特别是作为抗脂质过氧化作用的抑制剂和/或用于使脑功能障碍正常化的药剂。

公开(公告)号：US5712254A

公开(公告)日：1998-01-27

申请号：US362947

申请日：1994-12-23

申请人： Haruyuki Chaki ,  Naoko Ando ,  Yasuhiro Morinaka ,  Ken-Ichi Saito ,  Tomoko Yugami ,  Rie Yoshida

发明人： Haruyuki Chaki ,  Naoko Ando ,  Yasuhiro Morinaka ,  Ken-Ichi Saito ,  Tomoko Yugami ,  Rie Yoshida

IPC分类号： C07J17/00 ,  C07J41/00 ,  A61K31/70 ,  A61K31/58 ,  C07D315/00

CPC分类号： C07J41/0005 ,  C07J17/005

摘要： Sialic acid derivatives represented by the general formula (I): ##STR1## wherein R.sup.1 is a steroidal compound residue; R.sup.2 is H or alkyl; R.sup.3 is alkyl; ##STR2## wherein each of R.sup.6 and R.sup.7 is H, alkyl or the like and I is an integer of 0 to 6; or the like; X is O or S; R.sup.4 is H or acyl; and R.sup.5 is R.sup.14 O-- (R.sup.14 is H or acyl) or R.sup.15 NH--(R.sup.15 is acyl or the like); their salts, hydrates or solvates are provided. Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.

摘要翻译： 由通式（I）表示的唾液酸衍生物：其中R1是甾族化合物残基; R2是H或烷基; R3是烷基; 其中R6和R7各自为H，烷基等，I为0-6的整数; 或类似物; X是O或S; R4是H或酰基; R5为R14O-（R14为H或酰基）或R15NH-（R15为酰基等）; 提供它们的盐，水合物或溶剂合物。 预期本发明的唾液酸衍生物是预防和治疗老年性痴呆（包括阿尔茨海默氏病等）的有效药物，因为它们增加胆碱能神经元中的ChAT活性。

公开(公告)号：US5399724A

公开(公告)日：1995-03-21

申请号：US128266

申请日：1993-09-28

申请人： Hisao Takayanagi ,  Yasunori Kitano ,  Yasuhiro Morinaka

发明人： Hisao Takayanagi ,  Yasunori Kitano ,  Yasuhiro Morinaka

IPC分类号： C07C43/315 ,  C07C47/263 ,  C07C47/277 ,  C07C69/734 ,  C07D307/20 ,  C07D309/12 ,  C07D57/02

CPC分类号： C07C47/263 ,  C07C43/315 ,  C07C47/277 ,  C07C69/734 ,  C07D307/20 ,  C07D309/12

摘要： Novel acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the following general formula (I): ##STR1## [wherein R.sup.1 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group; R.sup.2 is a group of formula: --CHO, --CH.sub.2 OR.sup.3 or ##STR2## (wherein R.sup.3 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group; and R.sup.4 is C.sub.1 to C.sub.4 alkyl group) with the proviso that R.sup.1 and R.sup.3 do not represent the same substituents simultaneously; when R.sup.1 is a hydrogen atom, R.sup.3 is not acetyl group or tetrahydropyranyl group; and when R.sup.2 is a group of formula: ##STR3## R.sup.1 is not a hydrogen atom).

摘要翻译： 新颖的无环萜烯化合物可用作生产具有抗致癌促进剂活性和抗肿瘤活性的唾液酸A的中间体，该化合物由以下通式（I）表示：其中R1是氢 原子，1-烷氧基烷基，四氢呋喃基，四氢吡喃基或酰基; R2是式-CHO，-CH2OR3或者其中R3是氢原子，1-烷氧基烷基，四氢呋喃基，四氢吡喃基或酰基，R4是C1-C4烷基的基团），条件是 R1和R3不同时表示相同的取代基; 当R1是氢原子时，R3不是乙酰基或四氢吡喃基; 并且当R 2是下式的基团时：R 1不是氢原子）。

公开(公告)号：US5395958A

公开(公告)日：1995-03-07

申请号：US126646

申请日：1993-09-27

申请人： Ryoichi Ando ,  Yasuhiro Morinaka ,  Eiichi Nakamura

发明人： Ryoichi Ando ,  Yasuhiro Morinaka ,  Eiichi Nakamura

IPC分类号： C07D319/08 ,  C07F7/08 ,  C07C69/74 ,  C07C215/00 ,  C07C233/00 ,  C07D327/00

CPC分类号： C07D319/08 ,  C07F7/0814

摘要： The cyclopropene derivatives of the present invention are useful as the intermediates for producing cyclopropenone derivatives exhibiting strong inhibition activity of thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L and the like.

摘要翻译： 本发明的环丙烯衍生物可用作产生表现出硫蛋白酶如钙蛋白酶，木瓜蛋白酶，组织蛋白酶B，组织蛋白酶H，组织蛋白酶L等的强抑制活性的环丙烯酮衍生物的中间体。

公开(公告)号：US4668677A

公开(公告)日：1987-05-26

申请号：US722304

申请日：1985-04-11

申请人： Yasuhiro Morinaka ,  Katsuhiko Iseki ,  Toshiji Kanayama ,  Toshiaki Watanabe ,  Hiroyoshi Nishi

发明人： Yasuhiro Morinaka ,  Katsuhiko Iseki ,  Toshiji Kanayama ,  Toshiaki Watanabe ,  Hiroyoshi Nishi

IPC分类号： A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/00 ,  C07D237/34 ,  C07D237/30

CPC分类号： C07D237/34

摘要： Certain new 1-alkylamino-4-phenylphthalazine derivatives, 1-neopentylamino-4-phenylphthalazine and 1-(1-ethylpropylamino)-4-phenylphthalazine, having prominent activity to ameliorate circulatory disorders and prepared from the corresponding phthalazinones.

摘要翻译： 某些新的1-烷基氨基-4-苯基酞嗪衍生物，1-新戊基氨基-4-苯基酞嗪和1-（1-乙基丙基氨基）-4-苯基酞嗪，具有改善循环障碍并由相应的2,3-二氮杂萘酮制备的活性。

公开(公告)号：US5397785A

公开(公告)日：1995-03-14

申请号：US115257

申请日：1993-09-02

申请人： Kunihiro Ninomiya, deceased ,  Ken-ichi Sato ,  Mamoru Sugano ,  Akihiro Tobe ,  Yasuhiro Morinaka ,  Tomoko Bessho ,  Haruko Harada

发明人： Kunihiro Ninomiya, deceased ,  Ken-ichi Sato ,  Mamoru Sugano ,  Akihiro Tobe ,  Yasuhiro Morinaka ,  Tomoko Bessho ,  Haruko Harada

IPC分类号： C07D219/10 ,  C07D221/16 ,  C07D221/20 ,  C07D221/22 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/44

CPC分类号： C07D221/20 ,  C07D219/10 ,  C07D221/16 ,  C07D221/22 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04

摘要： A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.

摘要翻译： 公开了由下式（I）表示的新型4-酰氨基吡啶衍生物。 （I）本发明的4-酰基氨基吡啶衍生物作为治疗老年性痴呆和阿尔茨海默氏病等记忆障碍的药物是有用的，因为它具有直接激活故障胆碱能神经元的作用。