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1.发明授权公开(公告)号：US07589221B2
公开(公告)日：2009-09-15
申请号：US10560176
申请日：2004-06-09
IPC分类号： C07B53/00 , C07C231/00 , C07C227/00
CPC分类号： C07C53/128 , C07B2200/07 , C07C231/06 , C07C309/73
摘要： The present invention relates to a process for producing (2R)-2-propyloctanoic acid, which comprises subjecting (2R)-2-hexyloxirane to a two-carbon adding reaction with ring-opening reaction, followed by a protecting reaction of a hydroxyl group to convert it to a compound represented by formula (I): (wherein X represents an optionally protected hydroxyl group) and then subjecting the compound to a one-carbon adding reaction to convert it to (2R)-2-propyloctanamide, followed by recrystallization and hydrolysis. According to the process of the present invention, (2R)-2-propyloctanoic acid can be produced by less steps as compared with the conventional method without a dangerous reaction.
摘要翻译： 本发明涉及（2R）-2-丙基辛酸的制备方法，其包括使（2R）-2-己氧基丙烯在开环反应中进行二碳加成反应，接着进行羟基的保护反应 将其转化为由式（I）表示的化合物：（其中X表示任选保护的羟基），然后使化合物进行一碳加成反应，将其转化为（2R）-2-丙基辛酰胺，然后重结晶 和水解。 根据本发明的方法，与没有危险反应的常规方法相比，可以通过较少的步骤制备（2R）-2-丙氧基辛酸。
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2.发明申请公开(公告)号：US20060135802A1
公开(公告)日：2006-06-22
申请号：US10560176
申请日：2004-06-09
IPC分类号： C07C51/15
CPC分类号： C07C53/128 , C07B2200/07 , C07C231/06 , C07C309/73
摘要： The present invention relates to a process for producing (2R)-2-propyloctanoic acid, which comprises subjecting (2R)-2-hexyloxirane to a two-carbon adding reaction with ring-opening reaction, followed by a protecting reaction of a hydroxyl group to convert it to a compound represented by formula (I): (wherein X represents an optionally protected hydroxyl group) and then subjecting the compound to a one-carbon adding reaction to convert it to (2R)-2-propyloctanamide, followed by recrystallization and hydrolysis. According to the process of the present invention, (2R)-2-propyloctanoic acid can be produced by less steps as compared with the conventional method without a dangerous reaction.
摘要翻译： 本发明涉及（2R）-2-丙基辛酸的制备方法，其包括使（2R）-2-己氧基丙烯在开环反应中进行二碳加成反应，接着进行羟基的保护反应 将其转化为由式（I）表示的化合物：（其中X表示任选保护的羟基），然后使化合物进行一碳加成反应，将其转化为（2R）-2-丙基辛酰胺，然后重结晶 和水解。 根据本发明的方法，与没有危险反应的常规方法相比，可以通过较少的步骤制备（2R）-2-丙氧基辛酸。
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公开(公告)号：US08273916B2
公开(公告)日：2012-09-25
申请号：US12872384
申请日：2010-08-31
IPC分类号： C07B57/00
CPC分类号： C07C53/128
摘要： According to the present invention, crystals comprising (2R)-2-propyloctanoic acid and an amine, which can be used as bulk drugs for safely orally administrable solid preparations with keeping the pharmacological effect, are provided. Among these crystals, the crystal with dibenzylamine per se is particularly useful as bulk drug for pharmaceuticals and can be used as an intermediate to produce (2R)-2-propyloctanoic acid having an optical purity of more than 99.5% e.e. which has not been obtained.
摘要翻译： 根据本发明，提供了包含（2R）-2-丙基辛酸和胺的晶体，其可以用作用于安全口服给药的固体制剂的主要药物，并具有药理作用。 在这些晶体中，具有二苄基胺本身的结晶特别可用作药物的大量药物，并且可以用作中间体以产生光学纯度大于99.5％e.e的（2R）-2-丙基辛酸。 尚未获得。
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公开(公告)号：US07820715B2
公开(公告)日：2010-10-26
申请号：US11579071
申请日：2005-04-27
IPC分类号： A61K31/205 , C07C229/00 , C07B57/00
CPC分类号： C07C53/128
摘要： Crystals comprising (2R)-2-propyloctoic acid and an amine which retain the pharmacological effect of (2R)-2-propyloctoic acid and can be safely used as a medicinal raw drug for peroral solid preparations. Of these crystals, the crystals especially with dibenzylamine are advantageous because not only the crystals themselves are useful as a medicinal raw drug but also use of the crystals as an intermediate can yield (2R)-2-propyloctoic acid having an optical purity exceeding 99.5% e.e., which has not been obtained hitherto.
摘要翻译： 包含（2R）-2-丙基辛酸和维持（2R）-2-丙基辛酸的药理作用的胺的晶体，可以安全地用作口服固体制剂的药用原料药。 在这些晶体中，特别是二苄胺的结晶是有利的，因为不仅晶体本身可用作药用原料，而且使用晶体作为中间体可以产生光学纯度超过99.5％的（2R）-2-丙基辛酸， ee，迄今尚未获得。
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公开(公告)号：US20080090907A1
公开(公告)日：2008-04-17
申请号：US11579071
申请日：2005-04-27
CPC分类号： C07C53/128
摘要： Crystals comprising (2R)-2-propyloctoic acid and an amine which retain the pharmacological effect of (2R)-2-propyloctoic acid and can be safely used as a medicinal raw drug for peroral solid preparations. Of these crystals, the crystals especially with dibenzylamine are advantageous because not only the crystals themselves are useful as a medicinal raw drug but also use of the crystals as an intermediate can yield (2R)-2-propyloctoic acid having an optical purity exceeding 99.5% e.e., which has not been obtained hitherto.
摘要翻译： 包含（2R）-2-丙基辛酸和维持（2R）-2-丙基辛酸的药理作用的胺的晶体，可以安全地用作口服固体制剂的药用原料药。 在这些晶体中，特别是二苄胺的结晶是有利的，因为不仅晶体本身可用作药用原料，而且使用晶体作为中间体可以产生光学纯度超过99.5％的（2R）-2-丙基辛酸， ee，迄今尚未获得。
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![8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d] pyrazolo[1,5-a]pyrimidine methanesulfonate as a CRF antagonist](/abs-image/US/2011/05/24/US07947697B1/abs.jpg.150x150.jpg)
6.发明授权8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d] pyrazolo[1,5-a]pyrimidine methanesulfonate as a CRF antagonist 有权8-（3-戊基氨基）-2-甲基-3-（2-氯-4-甲氧基苯基）-6,7-二氢-5H-环戊二烯并[d]吡唑并[1,5-a]嘧啶甲磺酸盐，为CRF拮抗剂公开(公告)号：US07947697B1
公开(公告)日：2011-05-24
申请号：US10561214
申请日：2004-06-24
申请人： Tomoyuki Hasegawa , Toshiaki Matsui , Hiroshi Araki , Tetsuji Saito , Tetsuo Obitsu , Masaki Okamoto , Yuichi Gemba , Yutaka Mikami
发明人： Tomoyuki Hasegawa , Toshiaki Matsui , Hiroshi Araki , Tetsuji Saito , Tetsuo Obitsu , Masaki Okamoto , Yuichi Gemba , Yutaka Mikami
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P25/24 , A61P3/04 , A61P25/22
CPC分类号： C07D487/04
摘要： 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine methanesulfonate of the structural formula (I) has Corticotropin Releasing Factor (CRF) antagonist activity and is useful in treating neuropsychiatric and digestive system diseases.
摘要翻译： 具有结构式的8-（3-戊基氨基）-2-甲基-3-（2-氯-4-甲氧基苯基）-6,7-二氢-5H-环戊并[d]吡唑并[1,5-a]嘧啶甲磺酸盐 （I）具有促肾上腺皮质激素释放因子（CRF）拮抗剂活性，可用于治疗神经精神和消化系统疾病。
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公开(公告)号：US08563871B2
公开(公告)日：2013-10-22
申请号：US13023650
申请日：2011-02-09
IPC分类号： H05K1/16
CPC分类号： B32B18/00 , C04B35/265 , C04B35/4682 , C04B37/005 , C04B2235/3215 , C04B2235/3232 , C04B2235/3279 , C04B2235/3281 , C04B2235/3284 , C04B2235/3298 , C04B2235/6025 , C04B2235/656 , C04B2235/96 , C04B2237/10 , C04B2237/34 , C04B2237/346 , C04B2237/708 , H01F1/344 , H01F41/0246 , H01F41/046 , H01G4/1227 , H01G4/40 , H03H1/0007 , H03H7/427
摘要： It is provided a composite electronic part having magnetic material and dielectric material and made by co-sintering at a temperature of 1000° C. or lower. The magnetic material comprises a ferrite comprising 46 to 48 mol % of Fe2O3, 0.1 to 36 mol % of ZnO, 10 to 14 mol % of CuO and the balance being NiO. The dielectric material has a dielectric constant of 1000 or higher, and comprises a barium titanate based dielectric material to which 0.5 to 4.0 weight parts of CuO and 4.0 to 9.0 weight parts of Bi2O3 are added with respect to 100 weight parts of the barium titanate based dielectric material.
摘要翻译： 提供了具有磁性材料和介电材料的复合电子部件，并通过在1000℃或更低的温度下共烧结制成。 磁性材料包括铁氧体，其包含46至48mol％的Fe 2 O 3，0.1至36mol％的ZnO，10至14mol％的CuO，余量为NiO。 电介质材料的介电常数为1000以上，并且包括钛酸钡系电介质材料，相对于100重量份的钛酸钡系，添加0.5〜4.0重量份的CuO和4.0〜9.0重量份Bi 2 O 3 介电材料。
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8.发明授权公开(公告)号：US08162744B2
公开(公告)日：2012-04-24
申请号：US12412720
申请日：2009-03-27
IPC分类号： G06F19/00
CPC分类号： G07F17/3267 , G07F17/3202 , G07F17/3211
摘要： A gaming machine of the present invention performs an effect of rotating an image displayed in each display block having a second specific symbol rearranged therein in a direction so as to turn a display screen of a display over to the other side after scroll-displaying a specific character image to the display in a direction from one side of a symbol display region toward the opposite side, and also changing the second specific symbol rearranged in the each display block into a first specific symbol, when the first specific symbol and the second specific symbol have been rearranged in the symbol display region and also when it has been determined to display the specific character image; and offers an award in accordance with the number of first specific symbols arranged in the symbol display region as a result thereof.
摘要翻译： 本发明的游戏机执行旋转显示在具有第二特定符号的每个显示块中的图像的方向，以便在滚动显示特定的图像之后将显示的显示屏幕转到另一侧 字符图像在从符号显示区域的一侧朝向相反侧的方向上显示，并且当第一特定符号和第二特定符号在每个显示块中重新排列为第一特定符号时，将第二特定符号改变为第一特定符号 已被重新排列在符号显示区域中，并且当已经确定显示特定字符图像时; 并作为其结果，根据排列在符号显示区域中的第一特定符号的数量提供奖励。
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公开(公告)号：US20120025746A1
公开(公告)日：2012-02-02
申请号：US13263088
申请日：2009-04-22
申请人： Mamoru Kawakubo , Mineo Yamamoto , Hiroyuki Ishii , Hiroki Aso , Tomoyuki Hasegawa , Togo Yamazaki
发明人： Mamoru Kawakubo , Mineo Yamamoto , Hiroyuki Ishii , Hiroki Aso , Tomoyuki Hasegawa , Togo Yamazaki
CPC分类号： H02K11/0005 , H02K5/1732 , H02K11/01 , H02K11/33 , H02K2211/03 , Y10T29/49009
摘要： In a motor driven by a drive circuit such as an inverter, there is a problem that electric current flowing through a bearing causes electric corrosion, which impairs the durability of the bearing. A motor of the invention includes: a stator in which a winding is applied through an insulating part to a stator core formed by laminating a predetermined number of electromagnetic steel plates which have been punched into a predetermined shape; a rotor assembly in which a rotor and bearings and formed by rolling bearings are fitted to a shaft; a printed wiring board which is arranged at an end part of the stator in an axial direction and to which a drive circuit is mounted; a bracket imposed to at least the end part of the stator in the axial direction to which the printed wiring board is arranged; and a conductive sheet provided between the printed wiring board and the bracket.
摘要翻译： 在由诸如逆变器的驱动电路驱动的电动机中，存在流过轴承的电流导致电腐蚀的问题，这损害了轴承的耐久性。 本发明的电动机包括：定子，其中通过绝缘部分将绕组施加到通过层压预定数量的被冲压成预定形状的电磁钢板而形成的定子芯; 转子组件，其中转子和由滚动轴承形成的轴承安装在轴上; 布置在所述定子的轴向端部并且安装有驱动电路的印刷电路板; 在布置有印刷线路板的轴向方向上至少施加到定子的端部的支架; 以及设置在印刷线路板和支架之间的导电片。
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公开(公告)号：US20060273179A1
公开(公告)日：2006-12-07
申请号：US10514495
申请日：2003-05-14
CPC分类号： G06K19/0739 , G06K19/07749
摘要： The present invention provides an IC tag which has a structure comprising a first adhesive layer formed on a surface of a substrate sheet, an electronic circuit and an IC chip connecting both ends of the electronic circuit, both formed on the surface of the first adhesive layer, and a second adhesive layer covering the electronic circuit and the IC chip. The IC tag further includes a release agent layer formed at positions corresponding to the both ends of the electronic circuit and located at the interface between the substrate sheet and the first adhesive layer. When the IC tag attached to an article is peeled off, the built-in electronic circuit is surely broken.
摘要翻译： 本发明提供一种IC标签，其具有包括形成在基板的表面上的第一粘合层，连接电子电路的两端的电子电路和IC芯片，二者形成在第一粘合层的表面上 以及覆盖电子电路和IC芯片的第二粘合层。 IC标签还包括形成在对应于电子电路的两端的位置并且位于基板和第一粘合剂层之间的界面处的脱模剂层。 当附着在物品上的IC标签被剥离时，内置的电子电路肯定会损坏。
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